Idi na sadržaj

PRUNE2

S Wikipedije, slobodne enciklopedije
PRUNE2
Identifikatori
AliasiPRUNE2
Vanjski ID-jeviOMIM: 610691 MGI: 1925004 HomoloGene: 18939 GeneCards: PRUNE2
Lokacija gena (čovjek)
Hromosom 9 (čovjek)
Hrom.Hromosom 9 (čovjek)[1]
Hromosom 9 (čovjek)
Genomska lokacija za PRUNE2
Genomska lokacija za PRUNE2
Bend9q21.2Početak76,611,376 bp[1]
Kraj76,906,114 bp[1]
Lokacija gena (miš)
Hromosom 19 (miš)
Hrom.Hromosom 19 (miš)[2]
Hromosom 19 (miš)
Genomska lokacija za PRUNE2
Genomska lokacija za PRUNE2
Bend19|19 BPočetak16,933,482 bp[2]
Kraj17,201,296 bp[2]
Ontologija gena
Molekularna funkcija GO:0097382 Pirofosfataza
vezivanje iona metala
exopolyphosphatase activity
Ćelijska komponenta citoplazma
Biološki proces GO:0097285 apoptoza
polyphosphate catabolic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001308047
NM_001308048
NM_001308049
NM_001308050
NM_001308051

NM_015225
NM_138818
NM_001330680

NM_181348

RefSeq (bjelančevina)
NP_001294976
NP_001294977
NP_001294978
NP_001294979
NP_001294980

NP_001317609
NP_056040
NP_001294976.1
NP_001294977.1

NP_851993

Lokacija (UCSC)Chr 9: 76.61 – 76.91 MbChr 19: 16.93 – 17.2 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Homolog 2 prunskog proteina je protein koji je kod ljudi kodiran genom PRUNE2.[5][6]

Aminokiselinska sekvenca

[uredi | uredi izvor]

Dužina polipeptidnog lanca je 3.088 aminokiselina, а molekulska težina 340.635 Da.[7]

1020304050
MEEFLQRAKSKLNRSKRLEKVHVVIGPKSCDLDSLISTFTYAYFLDKVSP
PGVLCLPVLNIPRTEFNYFTETRFILEELNISESFHIFRDEINLHQLNDE
GKLSITLVGSSVLASEDKTLESAVVKVINPVEQSDANVEFRESSSSLVLK
EILQEAPELITEQLAHRLRGSILFKWMTMESEKISEKQEEILSILEEKFP
NLPPREDIINVLQETQFSAQGLSIEQTMLKDLKELSDGEIKVAISTVSMN
LENCLFHSNITSDLKAFTDKFGFDVLILFSSYLSEEQQPRRQIAVYSENM
ELCSQICCELEECQNPCLELEPFDCGCDEILVYQQEDPSVTCDQVVLVVK
EVINRRCPEMVSNSRTSSTEAVAGSAPLSQGSSGIMELYGSDIEPQPSSV
NFIENPPDLNDSNQAQVDANVDLVSPDSGLATIRSSRSSKESSVFLSDDS
PVGEGAGPHHTLLPGLDSYSPIPEGAVAEEHAWSGEHGEHFDLFNFDPAP
MASGQSQQSSHSADYSPADDFFPNSDLSEGQLPAGPEGLDGMGTNMSNYS
SSSLLSGAGKDSLVEHDEEFVQRQDSPRDNSERNLSLTDFVGDESPSPER
LKNTGKRIPPTPMNSLVESSPSTEEPASLYTEDMTQKATDTGHMGPPQTH
ARCSSWWGGLEIDSKNIADAWSSSEQESVFQSPESWKEHKPSSIDRRASD
SVFQPKSLEFTKSGPWESEFGQPELGSNDIQDKNEESLPFQNLPMEKSPL
PNTSPQGTNHLIEDFASLWHSGRSPTAMPEPWGNPTDDGEPAAVAPFPAW
SAFGKEDHDEALKNTWNLHPTSSKTPSVRDPNEWAMAKSGFAFSSSELLD
NSPSEINNEAAPEIWGKKNNDSRDHIFAPGNPSSDLDHTWTNSKPPKEDQ
NGLVDPKTRGKVYEKVDSWNLFEENMKKGGSDVLVPWEDSFLSYKCSDYS
ASNLGEDSVPSPLDTNYSTSDSYTSPTFAGDEKETEHKPFAKEEGFESKD
GNSTAEETDIPPQSLQQSSRNRISSGPGNLDMWASPHTDNSSEINTTHNL
DENELKTEHTDGKNISMEDDVGESSQSSYDDPSMMQLYNETNRQLTLLHS
STNSRQTAPDSLDLWNRVILEDTQSTATISDMDNDLDWDDCSGGAAIPSD
GQTEGYMAEGSEPETRFTVRQLEPWGLEYQEANQVDWELPASDEHTKDSA
PSEHHTLNEKSGQLIANSIWDSVMRDKDMSSFMLPGSSHITDSEQRELPP
EIPSHSANVKDTHSPDAPAASGTSESEALISHLDKQDTERETLQSDAASL
ATRLENPGYFPHPDPWKGHGDGQSESEKEAQGATDRGHLDEEEVIASGVE
NASGISEKGQSDQELSSLVASEHQEICIKSGKISSLAVTFSPQTEEPEEV
LEYEEGSYNLDSRDVQTGMSADNLQPKDTHEKHLMSQRNSGETTETSDGM
NFTKYVSVPEKDLEKTEECNFLEPENVGGGPPHRVPRSLDFGDVPIDSDV
HVSSTCSEITKNLDVKGSENSLPGAGSSGNFDRDTISSEYTHSSASSPEL
NDSSVALSSWGQQPSSGYQEENQGNWSEQNHQESELITTDGQVEIVTKVK
DLEKNRINEFEKSFDRKTPTFLEIWNDSVDGDSFSSLSSPETGKYSEHSG
THQESNLIASYQEKNEHDISATVQPEDARVISTSSGSDDDSVGGEESIEE
EIQVANCHVAEDESRAWDSLNESNKFLVTADPKSENIYDYLDSSEPAENE
NKSNPFCDNQQSSPDPWTFSPLTETEMQITAVEKEKRSSPETGTTGDVAW
QISPKASFPKNEDNSQLEMLGFSADSTEWWKASPQEGRLIESPFERELSD
SSGVLEINSSVHQNASPWGVPVQGDIEPVETHYTNPFSDNHQSPFLEGNG
KNSHEQLWNIQPRQPDPDADKFSQLVKLDQIKEKDSREQTFVSAAGDELT
PETPTQEQCQDTMLPVCDHPDTAFTHAEENSCVTSNVSTNEGQETNQWEQ
EKSYLGEMTNSSIATENFPAVSSPTQLIMKPGSEWDGSTPSEDSRGTFVP
DILHGNFQEGGQLASAAPDLWIDAKKPFSLKADGENPDILTHCEHDSNSQ
ASDSPDICHDSEAKQETEKHLSACMGPEVESSELCLTEPEIDEEPIYEPG
REFVPSNAELDSENATVLPPIGYQADIKGSSQPASHKGSPEPSEINGDNS
TGLQVSEKGASPDMAPILEPVDRRIPRIENVATSIFVTHQEPTPEGDGSW
ISDSFSPESQPGARALFDGDPHLSTENPALVPDALLASDTCLDISEAAFD
HSFSDASGLNTSTGTIDDMSKLTLSEGHPETPVDGDLGKQDICSSEASWG
DFEYDVMGQNIDEDLLREPEHFLYGGDPPLEEDSLKQSLAPYTPPFDLSY
LTEPAQSAETIEEAGSPEDESLGCRAAEIVLSALPDRRSEGNQAETKNRL
PGSQLAVLHIREDPESVYLPVGAGSNILSPSNVDWEVETDNSDLPAGGDI
GPPNGASKEISELEEEKTIPTKEPEQIKSEYKEERCTEKNEDRHALHMDY
ILVNREENSHSKPETCEERESIAELELYVGSKETGLQGTQLASFPDTCQP
ASLNERKGLSAEKMSSKSDTRSSFESPAQDQSWMFLGHSEVGDPSLDARD
SGPGWSGKTVEPFSELGLGEGPQLQILEEMKPLESLALEEASGPVSQSQK
SKSRGRAGPDAVTLQAVTHDNEWEMLSPQPVQKNMIPDTEMEEETEFLEL
GTRISRPNGLLSEDVGMDIPFEEGVLSPSAADMRPEPPNSLDLNDTHPRR
IKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYT
GHDPTANKDSGQESESIPEYTAEEEREDNRLWRTVVIGEQEQRIDMKVIE
PYRRVISHGGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTL
ELMVAEDYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVH
PSWFIRTILAVTRPFISSKFSSKIKYVNSLSELSGLIPMDCIHIPESIIK
LDEELREASEAAKTSCLYNDPEMSSMEKDIDLKLKEKP

Reference

[uredi | uredi izvor]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106772 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039126 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Machida T, Fujita T, Ooo ML, Ohira M, Isogai E, Mihara M, Hirato J, Tomotsune D, Hirata T, Fujimori M, Adachi W, Nakagawara A (Mar 2006). "Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas". Oncogene. 25 (13): 1931–42. doi:10.1038/sj.onc.1209225. PMID 16288218.
  6. ^ "Entrez Gene: PRUNE2 prune homolog 2 (Drosophila)".
  7. ^ "UniProt, Q8WUY3". Pristupljeno 11. 9. 2021.

Dopunska literatura

[uredi | uredi izvor]