HIST1H1B

HIST1H1B
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2RHI
Identifikatori
Aliasi	H1-5
Vanjski ID-jevi	OMIM: 142711 MGI: 1861461 HomoloGene: 136789 GeneCards: H1-5
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek) Bend 6p22.1 Početak 27,866,792 bp Kraj 27,867,588 bp
Lokacija gena (miš) Hrom. Hromosom 13 (miš) Bend 13|13 A3.1 Početak 21,964,053 bp Kraj 21,964,795 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa DNK • histone deacetylase binding • chromatin DNA binding • vezivanje sa RNK • GO:0001948, GO:0016582 vezivanje za proteine • double-stranded DNA binding • nucleosomal DNA binding Ćelijska komponenta • Nukleosom • Egzosom • hromosom • jedro Biološki proces • establishment of protein localization to chromatin • nucleosome assembly • protein stabilization • positive regulation of cell growth • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • positive regulation of histone H3-K9 methylation • GO:0009373 regulation of transcription, DNA-templated • chromosome condensation • negative regulation of DNA recombination • muscle organ development Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3009	56702
Ensembl	ENSG00000184357	ENSMUSG00000058773
UniProt	P16401	P43276
RefSeq (mRNK)	NM_005322	NM_020034
RefSeq (bjelančevina)	NP_005313	NP_064418
Lokacija (UCSC)	Chr 6: 27.87 – 27.87 Mb	Chr 13: 21.96 – 21.96 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Histon H1.5 jest protein koji je kod ljudi kodiran genom HIST1H1B sa hromosoma 6.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 226 aminokiselina, a molekulska težina 22.580 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSETAPAETA		TPAPVEKSPA		KKKATKKAAG		AGAAKRKATG		PPVSELITKA
VAASKERNGL		SLAALKKALA		AGGYDVEKNN		SRIKLGLKSL		VSKGTLVQTK
GTGASGSFKL		NKKAASGEAK		PKAKKAGAAK		AKKPAGATPK		KAKKAAGAKK
AVKKTPKKAK		KPAAAGVKKV		AKSPKKAKAA		AKPKKATKSP		AKPKAVKPKA
AKPKAAKPKA		AKPKAAKAKK		AAAKKK

Funkcija

Histoni su osnovni jedarni proteini odgovorni za strukturu nukleosoma hromosomskog vlakna kod eukariota. Dvije molekule svakog od četiri jezgarna histona (H2A, H2B, H3 i H4) formiraju oktamer, oko kojeg je omotano oko 146 bp DNK u ponavljajuće jedinice, zvane nukleosomi. Linkerski histon, H1, stupa u interakciju s DNK povezivača između nukleosoma i funkcionira u zbijanju hromatina u strukture višeg reda. Ovaj gen je bez introna i kodira člana porodice histona H1. Transkripti ovog gena nemaju poliA repove, ali umjesto toga sadrže palindromski terminacijski element. Ovaj gen nalazi se u malom klasteru histonskih gena na hromosomskoj regiji 6p22-p21.3.

Dopunska literatura

• Ohe Y, Hayashi H, Iwai K (1990). "Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d". J. Biochem. 106 (5): 844–57. doi:10.1093/oxfordjournals.jbchem.a122941. PMID 2613692.
• van Wijnen AJ, Wright KL, Massung RF, et al. (1988). "Two target sites for protein binding in the promoter region of a cell cycle regulated human H1 histone gene". Nucleic Acids Res. 16 (2): 571–92. doi:10.1093/nar/16.2.571. PMC 334679. PMID 2829131.
• Collar DG, Wright KL, van Wijnen AJ, et al. (1988). "The human H1 histone gene FNC16 is functionally expressed in proliferating HeLa S3 cells and is down-regulated during terminal differentiation in HL60 cells". J. Biol. Chem. 263 (31): 15860–3. doi:10.1016/S0021-9258(18)37527-6. PMID 3182772.
• Ohe Y, Hayashi H, Iwai K (1986). "Human spleen histone H1. Isolation and amino acid sequence of a main variant, H1b". J. Biochem. 100 (2): 359–68. doi:10.1093/oxfordjournals.jbchem.a121722. PMID 3782055.
• Carozzi N, Marashi F, Plumb M, et al. (1984). "Clustering of human H1 and core histone genes". Science. 224 (4653): 1115–7. Bibcode:1984Sci...224.1115C. doi:10.1126/science.6719136. PMID 6719136.
• Aprelikova O, Xiong Y, Liu ET (1995). "Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase". J. Biol. Chem. 270 (31): 18195–7. doi:10.1074/jbc.270.31.18195. PMID 7629134.
• Albig W, Drabent B, Kunz J, et al. (1993). "All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6". Genomics. 16 (3): 649–54. doi:10.1006/geno.1993.1243. PMID 8325638.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
• New L, Zhao M, Li Y, et al. (1999). "Cloning and characterization of RLPK, a novel RSK-related protein kinase". J. Biol. Chem. 274 (2): 1026–32. doi:10.1074/jbc.274.2.1026. PMID 9873047.
• Chadwick BP, Willard HF (2001). "A Novel Chromatin Protein, Distantly Related to Histone H2a, Is Largely Excluded from the Inactive X Chromosome". J. Cell Biol. 152 (2): 375–84. doi:10.1083/jcb.152.2.375. PMC 2199617. PMID 11266453.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Giampuzzi M, Oleggini R, Di Donato A (2003). "Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved". Biochim. Biophys. Acta. 1647 (1–2): 245–51. doi:10.1016/s1570-9639(03)00059-1. PMID 12686141.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Vaquero A, Scher M, Lee D, et al. (2004). "Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin". Mol. Cell. 16 (1): 93–105. doi:10.1016/j.molcel.2004.08.031. PMID 15469825.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Garcia BA, Busby SA, Barber CM, et al. (2005). "Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry". J. Proteome Res. 3 (6): 1219–27. doi:10.1021/pr0498887. PMID 15595731.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.