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G6B

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G6B
Identifikatori
AliasiMPIG6B
Vanjski ID-jeviOMIM: 606520 MGI: 2146995 HomoloGene: 82249 GeneCards: MPIG6B
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za G6B
Genomska lokacija za G6B
Bend6p21.33Početak31,718,594 bp[1]
Kraj31,726,714 bp[1]
Lokacija gena (miš)
Hromosom 17 (miš)
Hrom.Hromosom 17 (miš)[2]
Hromosom 17 (miš)
Genomska lokacija za G6B
Genomska lokacija za G6B
Bend17|17 B1Početak35,281,669 bp[2]
Kraj35,285,160 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija heparin binding
GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta integral component of membrane
ćelijska membrana
Endoplazmatski retikulum
membrana
Golđijev aparat
Biološki proces platelet activation
negative regulation of signal transduction
integrin-mediated signaling pathway
Koagulacija (krv)
erythrocyte differentiation
megakaryocyte differentiation
platelet formation
megakaryocyte development
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
ENSG00000206396
ENSG00000224393
ENSG00000204420
ENSG00000237459
ENSG00000230060
UniProt
RefSeq (mRNK)
NM_025260
NM_138272
NM_138273
NM_138274
NM_138275

NM_138276
NM_138277

NM_001033221
NM_001191012

RefSeq (bjelančevina)
NP_079536
NP_612116
NP_612117
NP_612118
NP_612119

NP_612121
NP_079536.2
NP_612116.1
NP_612117.1
NP_612118.1
NP_612119.1
NP_612121.1

NP_001028393
NP_001177941

Lokacija (UCSC)Chr 6: 31.72 – 31.73 MbChr 17: 35.28 – 35.29 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein G6b jest protein koji je kod ljudi kodiran genom G6B ili C6orf25.[5][6][7]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 241 aminokiselina, а molekulska težina 26.163 Da.[8]

1020304050
MAVFLQLLPLLLSRAQGNPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSF
PACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSA
GDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIPLLGA
GLVLGLGALGLVWWLHRRLPPQPIRPLPRFAPLVKTEPQRPVKEEEPKIP
GDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV

Funkcija

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Ovaj gen je član natporodice imunoglobulina (Ig) i nalazi se u regiji klase III glavnog kompleksa histokompatibilnosti (MHC). Protein kodiran ovim genom je glikozilirani receptor ćelijske površine vezan za plazmamembranu, ali su topljive izoforme kodirane nekim varijantama transkripta u endoplazmatskom retikulumu i Golgijevom aparatu prije izlučivanja. Za ovaj gen pronađeno je više varijanti transkripta koje kodiraju različite izoforme.[7]

Reference

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  1. ^ a b c ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 GRCh38: Ensembl release 89: ENSG00000206396, ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073414 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD (Jul 1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J Immunol. 163 (1): 278–87. PMID 10384126.
  6. ^ de Vet EC, Aguado B, Campbell RD (Nov 2001). "G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2". J Biol Chem. 276 (45): 42070–6. doi:10.1074/jbc.M103214200. PMID 11544253.
  7. ^ a b "Entrez Gene: C6orf25 chromosome 6 open reading frame 25".
  8. ^ "UniProt, O95866" (jezik: engleski). Zanemaren tekst "2021-10-02" (pomoć)

Dopunska literatura

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