DKK3

DKK3
Identifikatori
Aliasi	DKK3
Vanjski ID-jevi	OMIM: 605416 MGI: 1354952 HomoloGene: 8303 GeneCards: DKK3
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek) Bend 11p15.3 Početak 11,956,207 bp Kraj 12,009,769 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7|7 F1 Početak 111,715,224 bp Kraj 111,758,264 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • co-receptor binding • receptor antagonist activity Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • negative regulation of anti-Mullerian hormone signaling pathway • multicellular organism development • negative regulation of cortisol biosynthetic process • negative regulation of Wnt signaling pathway • anatomical structure morphogenesis • GO:0045996 negative regulation of transcription, DNA-templated • Wnt-signalni put • adrenal gland development • negative regulation of canonical Wnt signaling pathway • regulation of transforming growth factor beta receptor signaling pathway • negative regulation of aldosterone biosynthetic process • extracellular negative regulation of signal transduction • negative regulation of signaling receptor activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	27122	50781
Ensembl	ENSG00000050165	ENSMUSG00000030772
UniProt	Q9UBP4	Q9QUN9
RefSeq (mRNK)	NM_001018057 NM_013253 NM_015881 NM_001330220	NM_015814 NM_001360257 NM_001360260 NM_001360261
RefSeq (bjelančevina)	NP_001018067 NP_001317149 NP_037385 NP_056965	NP_056629 NP_001347186 NP_001347189 NP_001347190
Lokacija (UCSC)	Chr 11: 11.96 – 12.01 Mb	Chr 7: 111.72 – 111.76 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dickkopfu-srodni protein 3 je protein porodice Dickkopf koji je kod ljudi kodiran genom DKK3.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 350 aminokiselina, a molekulska težina 38.390 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MQRLGATLLC		LLLAAAVPTA		PAPAPTATSA		PVKPGPALSY		PQEEATLNEM
FREVEELMED		TQHKLRSAVE		EMEAEEAAAK		ASSEVNLANL		PPSYHNETNT
DTKVGNNTIH		VHREIHKITN		NQTGQMVFSE		TVITSVGDEE		GRRSHECIID
EDCGPSMYCQ		FASFQYTCQP		CRGQRMLCTR		DSECCGDQLC		VWGHCTKMAT
RGSNGTICDN		QRDCQPGLCC		AFQRGLLFPV		CTPLPVEGEL		CHDPASRLLD
LITWELEPDG		ALDRCPCASG		LLCQPHSHSL		VYVCKPTFVG		SRDQDGEILL
PREVPDEYEV		GSFMEEVRQE		LEDLERSLTE		EMALREPAAA		AAALLGGEEI

Funkcija

Ovaj gen kodira protein koji je član porodice dickkopf. Izlučeni protein sadrži dvije regije bogate cisteinom i uključen je u razvoj embriona kroz interakcije sa signalnim putem Wnt. Ekspresija ovog gena je smanjena u različitim linijama ćelija raka i može funkcionirati kao genski supresor tumora. alternativna prerada rezultira u više varijanti transkripta koje kodiraju isti protein.

Dopunska literatuera

• Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (april 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (april 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Tsuji T, Miyazaki M, Sakaguchi M, Inoue Y, Namba M (februar 2000). "A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines". Biochemical and Biophysical Research Communications. 268 (1): 20–4. doi:10.1006/bbrc.1999.2067. PMID 10652205.
• Kobayashi K, Ouchida M, Tsuji T, Hanafusa H, Miyazaki M, Namba M, et al. (januar 2002). "Reduced expression of the REIC/Dkk-3 gene by promoter-hypermethylation in human tumor cells". Gene. 282 (1–2): 151–8. doi:10.1016/S0378-1119(01)00838-1. PMID 11814687.
• Mao B, Niehrs C (januar 2003). "Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling". Gene. 302 (1–2): 179–83. doi:10.1016/S0378-1119(02)01106-X. PMID 12527209.
• Kurose K, Sakaguchi M, Nasu Y, Ebara S, Kaku H, Kariyama R, et al. (mart 2004). "Decreased expression of REIC/Dkk-3 in human renal clear cell carcinoma". The Journal of Urology. 171 (3): 1314–8. doi:10.1097/01.ju.0000101047.64379.d4. PMID 14767340.
• Hoang BH, Kubo T, Healey JH, Yang R, Nathan SS, Kolb EA, et al. (april 2004). "Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway". Cancer Research. 64 (8): 2734–9. doi:10.1158/0008-5472.CAN-03-1952. PMID 15087387.
• Roman-Gomez J, Jimenez-Velasco A, Agirre X, Castillejo JA, Navarro G, Barrios M, et al. (august 2004). "Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia". British Journal of Cancer. 91 (4): 707–13. doi:10.1038/sj.bjc.6602008. PMC 2364778. PMID 15226763.
• Zhang Z, Henzel WJ (oktobar 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Hsieh SY, Hsieh PS, Chiu CT, Chen WY (decembar 2004). "Dickkopf-3/REIC functions as a suppressor gene of tumor growth". Oncogene. 23 (57): 9183–9. doi:10.1038/sj.onc.1208138. PMID 15516983.
• Ftouh S, Akbar MT, Hirsch SR, de Belleroche JS (juli 2005). "Down-regulation of Dickkopf 3, a regulator of the Wnt signalling pathway, in elderly schizophrenic subjects". Journal of Neurochemistry. 94 (2): 520–30. doi:10.1111/j.1471-4159.2005.03239.x. PMID 15998302. S2CID 679696.
• Kuphal S, Lodermeyer S, Bataille F, Schuierer M, Hoang BH, Bosserhoff AK (august 2006). "Expression of Dickkopf genes is strongly reduced in malignant melanoma". Oncogene. 25 (36): 5027–36. doi:10.1038/sj.onc.1209508. PMID 16568085.
• Urakami S, Shiina H, Enokida H, Kawakami T, Kawamoto K, Hirata H, et al. (april 2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection". Clinical Cancer Research. 12 (7 Pt 1): 2109–16. doi:10.1158/1078-0432.CCR-05-2468. PMID 16609023.
• Veeck J, Bektas N, Hartmann A, Kristiansen G, Heindrichs U, Knüchel R, Dahl E (2008). "Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours". Breast Cancer Research. 10 (5): R82. doi:10.1186/bcr2151. PMC 2614517. PMID 18826564.
• Veeck J, Wild PJ, Fuchs T, Schüffler PJ, Hartmann A, Knüchel R, Dahl E (juli 2009). "Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer". BMC Cancer. 9: 217. doi:10.1186/1471-2407-9-217. PMC 2717119. PMID 19570204.