Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jul 27, 2024; 16(7): 2308-2318
Published online Jul 27, 2024. doi: 10.4240/wjgs.v16.i7.2308
Impacts of different pancreatic resection ranges on endocrine function in Suncus murinus
Ru-Jia Li, Ting Yang, Yu-Hao Zeng, Yutaro Natsuyama, Ke Ren, Jun Li, Yuichi Nagakawa, Shuang-Qin Yi
Ru-Jia Li, Ting Yang, Yu-Hao Zeng, Yutaro Natsuyama, Shuang-Qin Yi, Department of Frontier Health Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo 116-8551, Japan
Ke Ren, Faculty of Physical Education, Qujing Normal University, Qujing 655000, Yunnan Province, China
Jun Li, School of Medicine, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai 200240, China
Yuichi Nagakawa, Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo 160-0023, Japan
Author contributions: Li RJ and Yi SQ acquired funding and designed and conceived the study; Li RJ, Yang T, and Zeng YH participated in experiments; Li RJ, Yi SQ, Ren K, and Li J analyzed the data; Li RJ wrote the article; Yi SQ revised the manuscript accordingly; All authors have contributed to the final version of the manuscript, and have read and approved the final manuscript.
Institutional animal care and use committee statement: All animal experiments were approved by the Institutional Animal Care and Use Committee of the Tokyo Metropolitan University (Permit No. A4-26 and No. A5-17).
Conflict-of-interest statement: The authors declare no conflicts of interest in association with the present study.
Data sharing statement: The authors confirm that the data supporting the findings of this study are available within the article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shuang-Qin Yi, MD, PhD, Professor, Department of Frontier Health Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, 7-2-10, Higashiogu, Arakawa-ku, Tokyo 116-8551, Japan. [email protected]
Received: March 11, 2024
Revised: May 23, 2024
Accepted: June 12, 2024
Published online: July 27, 2024
Processing time: 133 Days and 7.7 Hours
Abstract
BACKGROUND

Surgical intervention involving the pancreas can lead to impaired glucose tolerance and other types of endocrine dysfunction. The scope of pancreatectomy and whether it includes the ventral pancreas are the key factors in the development of postoperative diabetes. The ventral and dorsal pancreases are almost separated in Suncus murinus (S. murinus).

AIM

To investigate the effects of different extents of pancreatic resection on endocrine function in S. murinus.

METHODS

Eight-week-old male S. murinus shrews were randomly divided into three experimental groups according to different pancreatic resection ranges as follows: ventral pancreatectomy (VPx) group; partial pancreatectomy (PPx) group; subtotal pancreatectomy (SPx) group; and a sham-operated group. Postprandial serum insulin, glucagon-like peptide-1 (GLP-1), pancreatic polypeptide (PP), and somatostatin (SST) levels, as well as food intake, weight, blood glucose, and glucose tolerance were regularly measured for each animal.

RESULTS

S. murinus treated with PPx and SPx suffered from varying degrees of impaired glucose tolerance, but only a small proportion of the SPx group developed diabetes. Only S. murinus in the SPx group showed a significant decrease in food intake accompanied by severe weight loss, as well as a significant increase in postprandial serum GLP-1 levels. Postprandial serum PP levels decreased in both the VPx and PPx groups, but not in the SPx group. Postprandial serum SST levels decreased in both VPx and PPx groups, but the decrease was marginal.

CONCLUSION

Severe weight loss after pancreatectomy may be related to loss of appetite caused by compensatory elevation of GLP-1. PP and GLP-1 may play a role in resisting blood glucose imbalance.

Keywords: Pancreatectomy; Glucose homeostasis; Endocrine dysfunction; Glucagon-like peptide-1; Pancreatic polypeptide

Core Tip: Surgical intervention involving the pancreas can lead to impaired glucose tolerance and other types of endocrine dysfunction. The scope of pancreatectomy and whether it includes the ventral pancreas are the key factors in development of postoperative diabetes. Here, we investigated the impacts of three different pancreatic resection ranges (all containing ventral pancreas resection) on endocrine function in Suncus murinus and found that severe weight loss after pancreatectomy may be related to loss of appetite caused by compensatory elevation of glucagon-like peptide-1 (GLP-1) and that pancreatic polypeptide and GLP-1 may play a non-negligible role in resisting blood glucose imbalance after pancreatectomy.