PIKKing a way to regulate inflammation (Q47803583)

5 February 2018

http://europepmc.org/abstract/MED/29359354

title

PIKKing a way to regulate inflammation (English)

1 reference

5 February 2018

http://europepmc.org/abstract/MED/29359354

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29359354%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Tara L Roberts

series ordinal

4

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6 June 2020

author name string

Hazel Quek

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29359354%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Martin F Lavin

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29359354%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

publication date

14 November 2017

1 reference

5 February 2018

http://europepmc.org/abstract/MED/29359354

published in

Immunology & Cell Biology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29359354%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

96

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6 June 2020

issue

1

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6 June 2020

page(s)

8-20

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6 June 2020

1 reference

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mTOR: from growth signal integration to cancer, diabetes and ageing

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DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity

21 January 2018

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Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage

21 January 2018

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Regulation of innate immune cell function by mTOR.

21 January 2018

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Intersection of mTOR and STAT signaling in immunity

21 January 2018

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MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells

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The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model

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mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

21 January 2018

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Smg1 haploinsufficiency predisposes to tumor formation and inflammation

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Cutting Edge: Direct Sensing of TLR7 Ligands and Type I IFN by the Common Myeloid Progenitor Promotes mTOR/PI3K-Dependent Emergency Myelopoiesis.

21 January 2018

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Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia.

21 January 2018

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Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses

21 January 2018

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Critical roles for Rictor/Sin1 complexes in interferon-dependent gene transcription and generation of antiproliferative responses

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Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

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Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1.

21 January 2018

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IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

21 January 2018

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The TSC-mTOR signaling pathway regulates the innate inflammatory response

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Natural Products as Tools for Defining How Cellular Metabolism Influences Cellular Immune and Inflammatory Function during Chronic Infection

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Crude Preparations of Helicobacter pylori Outer Membrane Vesicles Induce Upregulation of Heme Oxygenase-1 via Activating Akt-Nrf2 and mTOR-IκB Kinase-NF-κB Pathways in Dendritic Cells

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nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

21 January 2018

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mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

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Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages.

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ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

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The innate immune response transcription factor relish is necessary for neurodegeneration in a Drosophila model of ataxia-telangiectasia

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ATM regulates NF-κB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment

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Phosphorylation of p65(RelA) on Ser(547) by ATM represses NF-κB-dependent transcription of specific genes after genotoxic stress

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DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function

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Stress granules regulate double-stranded RNA-dependent protein kinase activation through a complex containing G3BP1 and Caprin1.

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21 January 2018

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CpG DNA Activates Survival in Murine Macrophages through TLR9 and the Phosphatidylinositol 3-Kinase-Akt Pathway

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Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation

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Involvement of DNA-PKcs in the IL-6 and IL-12 response to CpG-ODN is mediated by its interaction with TRAF6 in dendritic cells

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1 reference

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Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs.

21 January 2018

1 reference

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DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.

21 January 2018

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A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus

21 January 2018

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Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

21 January 2018

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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 January 2018

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA

21 January 2018

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Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint

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DNA viruses and the cellular DNA-damage response

21 January 2018

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Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding

21 January 2018

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Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase

21 January 2018

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Downregulation of the stress-induced ligand ULBP1 following SV40 infection confers viral evasion from NK cell cytotoxicity

21 January 2018

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Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity

21 January 2018

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Deregulation of mTOR signaling is involved in thymic lymphoma development in Atm-/- mice

21 January 2018

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Mitochondria are required for pro-ageing features of the senescent phenotype.

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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

21 January 2018

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The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells

21 January 2018

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hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress

21 January 2018

1 reference

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Importance of PIKKs in NF-κB activation by genotoxic stress

21 January 2018

1 reference

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AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay

21 January 2018

1 reference

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Tel2 regulates the stability of PI3K-related protein kinases

21 January 2018

1 reference

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Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.

21 January 2018

1 reference

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DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

21 January 2018

1 reference

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Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production

21 January 2018

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21 January 2018

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Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes

21 January 2018

1 reference

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Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMCB.1001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29359354%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference