mTOR: from growth signal integration to cancer, diabetes and ageing (Q24633662)

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18 January 2020

review article

1 reference

title

mTOR: from growth signal integration to cancer, diabetes and ageing (English)

1 reference

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18 January 2020

0 references

2

1 reference

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18 January 2020

David M. Sabatini

series ordinal

3

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18 January 2020

author name string

Roberto Zoncu

series ordinal

1

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18 January 2020

language of work or name

English

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publication date

15 December 2010

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Nature Reviews Molecular Cell Biology

18 January 2020

published in

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18 January 2020

volume

12

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18 January 2020

issue

1

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18 January 2020

page(s)

21-35

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Extending healthy life span--from yeast to humans

18 January 2020

cites work

1 reference

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

7 April 2017

1 reference

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Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

7 April 2017

1 reference

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Atg101, a novel mammalian autophagy protein interacting with Atg13

7 April 2017

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

7 April 2017

1 reference

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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

7 April 2017

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

7 April 2017

1 reference

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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

7 April 2017

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

7 April 2017

1 reference

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mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

7 April 2017

1 reference

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

7 April 2017

1 reference

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

7 April 2017

1 reference

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Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

7 April 2017

1 reference

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

7 April 2017

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

7 April 2017

1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

7 April 2017

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SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs

7 April 2017

1 reference

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PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

7 April 2017

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The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Selective degradation of mitochondria by mitophagy

7 April 2017

1 reference

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Identification of Protor as a novel Rictor-binding component of mTOR complex-2

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

7 April 2017

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

7 April 2017

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

7 April 2017

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mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

7 April 2017

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mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

7 April 2017

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

7 April 2017

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

7 April 2017

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

7 April 2017

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Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

7 April 2017

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

7 April 2017

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Regulation of TSC2 by 14-3-3 binding

7 April 2017

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

7 April 2017

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

7 April 2017

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Tor-mediated induction of autophagy via an Apg1 protein kinase complex

7 April 2017

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Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E

7 April 2017

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A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

7 April 2017

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Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

7 April 2017

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

7 April 2017

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TOR signaling in growth and metabolism

7 April 2017

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TSC2 mediates cellular energy response to control cell growth and survival

7 April 2017

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

7 April 2017

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The Vam6 GEF controls TORC1 by activating the EGO complex

7 April 2017

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TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain

7 April 2017

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A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast

7 April 2017

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Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

7 April 2017

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Molecular organization of target of rapamycin complex 2.

7 April 2017

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The TOR and EGO protein complexes orchestrate microautophagy in yeast

7 April 2017

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TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1.

7 April 2017

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Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1.

7 April 2017

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Regulation of longevity and stress resistance by Sch9 in yeast

7 April 2017

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The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake

7 April 2017

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TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae

7 April 2017

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Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

7 April 2017

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The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

7 April 2017

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TOR controls translation initiation and early G1 progression in yeast

7 April 2017

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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

7 April 2017

1 reference

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

7 April 2017

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Cancer cell metabolism: Warburg and beyond

7 April 2017

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Defining the role of mTOR in cancer

7 April 2017

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Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

7 April 2017

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

7 April 2017

1 reference

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

7 April 2017

1 reference

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

7 April 2017

1 reference

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Hypothalamic mTOR signaling regulates food intake

7 April 2017

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

The LKB1 tumor suppressor negatively regulates mTOR signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Regulation mechanisms and signaling pathways of autophagy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Autophagy regulates lipid metabolism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

The role of autophagy during the early neonatal starvation period

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Termination of autophagy and reformation of lysosomes regulated by mTOR

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Molecular mechanisms of mTOR-mediated translational control

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Regulation of TORC1 by Rag GTPases in nutrient response

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Genetics: influence of TOR kinase on lifespan in C. elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Akt regulates growth by directly phosphorylating Tsc2

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Structure of the human mTOR complex I and its implications for rapamycin inhibition.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

mTOR and cancer: many loops in one pathway.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Mechanisms of stem cell self-renewal

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Differential requirement of mTOR in postmitotic tissues and tumorigenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Dissecting eIF4E action in tumorigenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Stress and mTORture signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Tor Pathway Regulates Rrn3p-dependent Recruitment of Yeast RNA Polymerase I to the Promoter but Does Not Participate in Alteration of the Number of Active Genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Rheb promotes cell growth as a component of the insulin/TOR signalling network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Mammalian TOR: a homeostatic ATP sensor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Regulation of eIF-4E BP1 phosphorylation by mTOR.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase

27 September 2017

1 reference

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Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Identification and characterization of a mitogen-activated S6 kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Control of p70 s6 kinase by kinase activity of FRAP in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

30 May 2018

1 reference

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Rapamycin-sensitive phase of 3T3-L1 preadipocyte differentiation after clonal expansion

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

Amino acid availability regulates p70 S6 kinase and multiple translation factors

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390257

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism

30 May 2018

1 reference

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Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.

30 May 2018

1 reference

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PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

28 November 2018

1 reference

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Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

28 November 2018

1 reference

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eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

28 November 2018

1 reference

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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

28 November 2018

1 reference

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Glutamatergic regulation of the p70S6 kinase in primary mouse neurons

28 November 2018

1 reference

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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

28 November 2018

1 reference

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

28 November 2018

1 reference

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Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

28 November 2018

1 reference

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Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

31 March 2020

1 reference

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

31 March 2020

1 reference

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Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner

31 March 2020

1 reference

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Bidirectional transport of amino acids regulates mTOR and autophagy

31 March 2020

1 reference

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A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

31 March 2020

1 reference

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PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

31 March 2020

1 reference

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Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

31 March 2020

1 reference

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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

31 March 2020

1 reference

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

31 March 2020

1 reference

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Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

31 March 2020

1 reference

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The forkhead transcription factor Foxo1 regulates adipocyte differentiation

31 March 2020

1 reference

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

31 March 2020

1 reference

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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

31 March 2020

1 reference

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Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

31 March 2020

1 reference

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PI3K pathway alterations in cancer: variations on a theme

31 March 2020

1 reference

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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

31 March 2020

1 reference

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p53-dependent translational control of senescence and transformation via 4E-BPs.

31 March 2020

1 reference

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4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

31 March 2020

1 reference

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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

31 March 2020

1 reference

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TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells

31 March 2020

1 reference

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Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.

31 March 2020

1 reference

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mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor

31 March 2020

1 reference

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31 March 2020

The genetics of ageing

1 reference

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

31 March 2020

1 reference

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Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9

31 March 2020

1 reference

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mTORC1 signals from late endosomes: taking a TOR of the endocytic system

31 March 2020

1 reference

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Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element

31 March 2020

1 reference

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TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21157483

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM3025

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21157483%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

18 January 2020

1025226207

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21157483%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

21157483

2 references