STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis (Q46506090)

22 December 2017

http://europepmc.org/abstract/MED/15912144

title

STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis (English)

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22 December 2017

http://europepmc.org/abstract/MED/15912144

1 reference

U Holtick

1

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22 December 2017

http://europepmc.org/abstract/MED/15912144

M Vockerodt

2

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http://europepmc.org/abstract/MED/15912144

D Pinkert

3

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http://europepmc.org/abstract/MED/15912144

N Schoof

4

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22 December 2017

http://europepmc.org/abstract/MED/15912144

B Stürzenhofecker

5

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http://europepmc.org/abstract/MED/15912144

N Kussebi

6

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http://europepmc.org/abstract/MED/15912144

K Lauber

7

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http://europepmc.org/abstract/MED/15912144

S Wesselborg

8

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http://europepmc.org/abstract/MED/15912144

D Löffler

9

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http://europepmc.org/abstract/MED/15912144

F Horn

10

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http://europepmc.org/abstract/MED/15912144

L Trümper

11

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http://europepmc.org/abstract/MED/15912144

D Kube

12

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22 December 2017

http://europepmc.org/abstract/MED/15912144

publication date

1 June 2005

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22 December 2017

http://europepmc.org/abstract/MED/15912144

published in

Leukemia

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22 December 2017

http://europepmc.org/abstract/MED/15912144

volume

19

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22 December 2017

http://europepmc.org/abstract/MED/15912144

issue

6

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22 December 2017

http://europepmc.org/abstract/MED/15912144

page(s)

936-944

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22 December 2017

http://europepmc.org/abstract/MED/15912144

cites work

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STAT3 is constitutively activated in Hodgkin cell lines

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Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors

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Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

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21 January 2018

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Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

21 January 2018

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Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

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Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF.

21 January 2018

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Inhibition of pancreatic cancer cell growth in vitro by the tyrphostin group of tyrosine kinase inhibitors

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Defective Bax activation in Hodgkin B-cell lines confers resistance to staurosporine-induced apoptosis

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Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

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In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3.

21 January 2018

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Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

21 January 2018

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Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.

21 January 2018

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Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB.

21 January 2018

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Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.

21 January 2018

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MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival

21 January 2018

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Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB.

21 January 2018

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Interleukin 1 Activates STAT3/Nuclear Factor-κB Cross-talk via a Unique TRAF6- and p65-dependent Mechanism

21 January 2018

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Transcriptional activation by STAT6 requires the direct interaction with NCoA-1

21 January 2018

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Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays

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7 January 2021

Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

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7 January 2021

JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells

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7 January 2021

Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403750

1 reference

22 December 2017

http://europepmc.org/abstract/MED/15912144

1 reference

22 December 2017