Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions (Q44691515)

5 December 2017

title

Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions (English)

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5 December 2017

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Shun Shimohama

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Hideyuki Sawada

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Ryuichi Kohno

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Takeshi Kihara

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Yasuhiko Izumi

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Noriko Sakka

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Miki Nakanishi

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Kentarou Yamakawa

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Hiroshi Shibasaki

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Noriyuki Yamamoto

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Akinori Akaike

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Masatoshi Inden

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Yoshihisa Kitamura

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Takashi Taniguchi

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5 December 2017

language of work or name

English

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publication date

12 December 2003

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Journal of Biological Chemistry

5 December 2017

published in

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5 December 2017

volume

279

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5 December 2017

issue

11

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5 December 2017

page(s)

10710-10719

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

5 December 2017

cites work

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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Brain proteasomal function in sporadic Parkinson's disease and related disorders

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Proteasomal function is impaired in substantia nigra in Parkinson's disease

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

21 January 2018

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Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

21 January 2018

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Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

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Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q.

21 January 2018

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Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations

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21 January 2018

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A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

21 January 2018

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

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Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on activities of the enzymes in the electron transport system in mouse brain

21 January 2018

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

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Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

21 January 2018

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Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies.

21 January 2018

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Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases

21 January 2018

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Bcl-2 and Bax proteins in Lewy bodies from patients with Parkinson's disease and Diffuse Lewy body disease

21 January 2018

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Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

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21 January 2018

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

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The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

21 January 2018

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Cell adhesion protects c-Raf-1 against ubiquitin-dependent degradation by the proteasome

21 January 2018

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Geldanamycin-induced destabilization of Raf-1 involves the proteasome

21 January 2018

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MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly

21 January 2018

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MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors

21 January 2018

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The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons

21 January 2018

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Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M308434200

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5 December 2017

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