interleukin 10 (Q423698)

http://www.ebi.ac.uk/interpro/protein/P22301

four-helical cytokine-like, core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22301

Interleukin-10, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

16 January 2019

1 reference

16 January 2019

5 references

8 April 2019

Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

Comparison of interleukin-22 and interleukin-10 soluble receptor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

growth factor activity

1 reference

8 April 2019

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

cytokine activity

Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

interleukin-10 receptor binding

protein dimerization activity

1 reference

8 April 2019

Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

cell component

extracellular region

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

Pro/anti-inflammatory cytokines in the pathogenesis of premature coronary artery disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of chronic inflammatory response to antigenic stimulus

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

positive regulation of MHC class II biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of endothelial cell apoptotic process

1 reference

8 April 2019

IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

hemopoiesis

1 reference

8 April 2019

Interleukin-10 and the interleukin-10 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of interferon-gamma production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

regulation of sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

positive regulation of B cell apoptotic process

1 reference

8 April 2019

The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of chemokine (C-C motif) ligand 5 production

1 reference

8 April 2019

A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

response to inactivity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of cytokine activity

1 reference

8 April 2019

Human interleukin 10 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of interleukin-1 production

1 reference

8 April 2019

A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

cellular response to hepatocyte growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

cellular response to estradiol stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of interleukin-6 production

A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

human ageing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

positive regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of cytokine production involved in immune response

1 reference

8 April 2019

Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

response to glucocorticoid

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

cytoplasmic sequestering of NF-kappaB

1 reference

8 April 2019

Interleukin 10 (IL-10)-mediated inhibition of inflammatory cytokine production by human alveolar macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of interleukin-18 production

1 reference

8 April 2019

A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of MHC class II biosynthetic process

1 reference

1 January 2018

Interleukin-10 and the interleukin-10 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22301&geneProductId=UniProtKB:P22301

response to activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

response to organic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

response to carbon monoxide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

leukocyte chemotaxis

1 reference

8 April 2019

Identification of functional domains on human interleukin 10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

type 2 immune response

1 reference

8 April 2019

Interleukin-10 and the interleukin-10 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of myeloid dendritic cell activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

response to insulin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of interleukin-8 production

1 reference

8 April 2019

A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

B cell proliferation

1 reference

8 April 2019

Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of T cell proliferation

negative regulation of nitric oxide biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

branching involved in labyrinthine layer morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

defense response to bacterium

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

regulation of complement-dependent cytotoxicity

1 reference

8 April 2019

IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

regulation of gene expression

1 reference

8 April 2019

The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

B cell differentiation

1 reference

8 April 2019

Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

regulation of isotype switching

1 reference

8 April 2019

Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of membrane protein ectodomain proteolysis

1 reference

8 April 2019

Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

inflammatory response

1 reference

8 April 2019

Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

cellular response to lipopolysaccharide

Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of B cell proliferation

1 reference

8 April 2019

The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of inflammatory response

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22301&geneProductId=UniProtKB:P22301

negative regulation of cytokine production

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22301&geneProductId=UniProtKB:P22301

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

defense response to protozoan

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

positive regulation of macrophage activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

liver regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

regulation of synapse organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

positive regulation of endothelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

positive regulation of heterotypic cell-cell adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

positive regulation of cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of mitotic cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

endothelial cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

positive regulation of vascular associated smooth muscle cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

interleukin-12-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

1 reference

8 April 2019

positive regulation of transcription, DNA-templated

Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

8 April 2019

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

negative regulation of cytokine production

negative regulation of autophagy

1 reference

8 April 2019

IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

1 reference

8 April 2019

negative regulation of MHC class II biosynthetic process

positive regulation of receptor signaling pathway via JAK-STAT

1 reference

8 April 2019

Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

positive regulation of sprouting angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301

http://purl.uniprot.org/uniprot/P22301

exact match

1 reference

Interleukin-10, conserved site

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22301

Commons category

Interferons or interleukin-10 (IL-10)

0 references

Identifiers

1 reference

16 November 2018

1 reference

16 January 2019

0 references

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016