A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response (Q41711854)

7 October 2017

title

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response (English)

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7 October 2017

Niwa M

1

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7 October 2017

Sidrauski C

series ordinal

2

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7 October 2017

Kaufman RJ

series ordinal

3

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7 October 2017

Walter P

series ordinal

4

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7 October 2017

language of work or name

English

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publication date

1 December 1999

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7 October 2017

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7 October 2017

volume

99

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7 October 2017

issue

7

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7 October 2017

page(s)

691-702

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

7 October 2017

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7 January 2021

Roles for proteolysis and trafficking in notch maturation and signal transduction

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Translational attenuation mediated by an mRNA intron

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Intracellular signaling from the endoplasmic reticulum to the nucleus

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The subnuclear localization of tRNA ligase in yeast

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7 January 2021

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

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Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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7 January 2021

Conservation and divergence of the yeast and mammalian unfolded protein response. Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1.

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Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway

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Somatic cell genetic and biochemical characterization of cell lines resulting from human genomic DNA transfections of Chinese hamster ovary cell mutants defective in sterol-dependent activation of sterol synthesis and LDL receptor expression

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7 January 2021

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

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7 January 2021

Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response

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7 January 2021

A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus

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7 January 2021

Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway

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7 January 2021

Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression

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Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

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Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

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7 January 2021

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

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7 January 2021

Splicing: HACking into the unfolded-protein response

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7 January 2021

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus

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The unfolded-protein-response pathway in yeast

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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7 January 2021

The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response

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7 January 2021

tRNA ligase is required for regulated mRNA splicing in the unfolded protein response

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7 January 2021

The unfolded protein response: an intracellular signalling pathway with many surprising features

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7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

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7 January 2021

The signal recognition particle receptor is a complex that contains two distinct polypeptide chains

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7 January 2021

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

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7 January 2021

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

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7 January 2021

The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation

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7 January 2021

Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi

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7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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7 January 2021

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

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7 January 2021

10.1016/S0092-8674(00)81667-0

Identifiers

DOI

1 reference

7 October 2017

1 reference