Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response (Q28139601)

1

0 references

K Imaizumi

2

0 references

N Sato

3

0 references

K Miyoshi

4

0 references

T Kudo

5

0 references

J Hitomi

6

0 references

T Morihara

7

0 references

T Yoneda

8

0 references

F Gomi

9

0 references

Y Mori

10

0 references

Y Nakano

11

0 references

J Takeda

12

0 references

T Tsuda

13

0 references

Y Itoyama

14

0 references

O Murayama

15

0 references

A Takashima

16

0 references

P St George-Hyslop

17

0 references

M Takeda

18

0 references

M Tohyama

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

19

0 references

language of work or name

English

0 references

publication date

December 1999

0 references

published in

Nature Cell Biology

0 references

volume

1

0 references

issue

8

0 references

page(s)

479-85

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

A familial Alzheimer's disease locus on chromosome 1.

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

The unfolded protein response: an intracellular signalling pathway with many surprising features

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Stress induction of the mammalian GRP78/BiP protein gene: in vivo genomic footprinting and identification of p70CORE from human nuclear extract as a DNA-binding component specific to the stress regulatory element

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Subcellular distribution and turnover of presenilins in transfected cells

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Establishment of a Chinese hamster ovary cell line that expresses grp78 antisense transcripts and suppresses A23187 induction of both GRP78 and GRP94

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase.

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion.

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

A high-efficiency HeLa cell nuclear transcription extract

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021

beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger

1 reference

https://api.crossref.org/works/10.1038%2F70265

7 January 2021