Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice. (Q40458602)

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scientific article published on 24 December 2004

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English	Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.	scientific article published on 24 December 2004

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15619115%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice (English)

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6 January 2020

elevated plus maze

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Anni-Maija Linden

1

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6 January 2020

author name string

H Shannon

2

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6 January 2020

M Baez

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6 January 2020

J L Yu

4

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6 January 2020

A Koester

5

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6 January 2020

D D Schoepp

6

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6 January 2020

publication date

24 December 2004

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6 January 2020

Psychopharmacology

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6 January 2020

179

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6 January 2020

1

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6 January 2020

284-291

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6 January 2020

Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxioly

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of a plus-maze to measure anxiety in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of lateral perforant path excitatory responses by metabotropic glutamate 8 (mGlu8) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of synaptic transmission by mGlu2 and mGlu3 at the perforant path inputs to the dentate gyrus and CA1 revealed in mGlu2 -/- mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neurotransmitter release by metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between LY354740, a group II metabotropic agonist and the GABA(A)-benzodiazepine receptor complex in the rat elevated plus-maze

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology and functions of metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antianxiety-like effects of antagonists of group I and agonists of group II and III metabotropic glutamate receptors after intrahippocampal administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/15619115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-004-2098-X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15619115%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15619115%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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