OX40, OX40L and Autoimmunity: a Comprehensive Review. (Q38555213)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26215166%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

review article

1 reference

title

OX40, OX40L and Autoimmunity: a Comprehensive Review (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26215166%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

author

Gideon M. Hirschfield

series ordinal

2

1 reference

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20 February 2020

Gwilym J Webb

series ordinal

1

1 reference

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20 February 2020

author name string

Peter J L Lane

series ordinal

3

1 reference

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20 February 2020

language of work or name

1 reference

1 June 2016

1 reference

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Clinical Reviews in Allergy & Immunology

20 February 2020

published in

1 reference

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20 February 2020

volume

50

1 reference

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20 February 2020

issue

3

1 reference

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20 February 2020

page(s)

312-332

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20 February 2020

1 reference

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Definition of human autoimmunity--autoantibodies versus autoimmune disease

21 January 2018

1 reference

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The epidemiology of autoimmune diseases

21 January 2018

1 reference

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Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

21 January 2018

1 reference

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Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor

21 January 2018

1 reference

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The significance of OX40 and OX40L to T-cell biology and immune disease.

21 January 2018

1 reference

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Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells

21 January 2018

1 reference

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Immune regulation and control of regulatory T cells by OX40 and 4-1BB

21 January 2018

1 reference

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4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine.

21 January 2018

1 reference

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Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.

21 January 2018

1 reference

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OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice

21 January 2018

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Agonist antibodies to TNFR molecules that costimulate T and NK cells

21 January 2018

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Functional expression of CD134 by neutrophils.

21 January 2018

1 reference

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Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers.

21 January 2018

1 reference

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OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

21 January 2018

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Control of immunity by the TNFR-related molecule OX40 (CD134)

21 January 2018

1 reference

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Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

21 January 2018

1 reference

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Establishment of a healthy human range for the whole blood "OX40" assay for the detection of antigen-specific CD4+ T cells by flow cytometry

21 January 2018

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OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-kappa B binding sites

21 January 2018

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OX40 controls effector CD4+ T-cell expansion, not follicular T helper cell generation in acute Listeria infection

21 January 2018

1 reference

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Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo

21 January 2018

1 reference

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OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis

21 January 2018

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Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo

21 January 2018

1 reference

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T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: comparison of gene expression profiles between human tonsillar and lung-cultured mast cells

21 January 2018

1 reference

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CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle.

21 January 2018

1 reference

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Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood

21 January 2018

1 reference

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The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells

21 January 2018

1 reference

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Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15).

21 January 2018

1 reference

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OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity

21 January 2018

1 reference

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Activated T cells express the OX40 ligand: requirements for induction and costimulatory function

21 January 2018

1 reference

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Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression.

21 January 2018

1 reference

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Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells

21 January 2018

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TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand.

21 January 2018

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IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway

21 January 2018

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Development of a sandwich ELISA for evaluating soluble OX40L (CD252) in human sera of different ages or with Graves' disease

21 January 2018

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The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion

21 January 2018

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Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.

21 January 2018

1 reference

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Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand.

21 January 2018

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Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA.

21 January 2018

1 reference

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OX40 signaling favors the induction of T(H)9 cells and airway inflammation

21 January 2018

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Activation of OX40 Augments Th17 Cytokine Expression and Antigen-Specific Uveitis

21 January 2018

1 reference

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Signaling through OX40 (CD134) breaks peripheral T-cell tolerance.

21 January 2018

1 reference

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Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.

21 January 2018

1 reference

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Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right

21 January 2018

1 reference

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New insights on OX40 in the control of T cell immunity and immune tolerance in vivo

21 January 2018

1 reference

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Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function.

21 January 2018

1 reference

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OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

21 January 2018

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OX40 ligand shuts down IL-10-producing regulatory T cells

21 January 2018

1 reference

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OX40 is required for regulatory T cell-mediated control of colitis

21 January 2018

1 reference

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OX40 costimulation turns off Foxp3+ Tregs.

21 January 2018

1 reference

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OX40-mediated memory T cell generation is TNF receptor-associated factor 2 dependent

21 January 2018

1 reference

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Critical, but conditional, role of OX40 in memory T cell-mediated rejection.

21 January 2018

1 reference

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Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells.

21 January 2018

1 reference

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OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection

21 January 2018

1 reference

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Costimulation of CD8 T cell responses by OX40.

21 January 2018

1 reference

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OX40 drives protective vaccinia virus-specific CD8 T cells

21 January 2018

1 reference

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Anti-OX40 prevents effector T-cell accumulation and CD8+ T-cell mediated skin allograft rejection

21 January 2018

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The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy

21 January 2018

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OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence

21 January 2018

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OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice

21 January 2018

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Cytokines and cell surface molecules independently induce CXCR4 expression on CD4+ CCR7+ human memory T cells.

21 January 2018

1 reference

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Signaling of gp34 (OX40 ligand) induces vascular endothelial cells to produce a CC chemokine RANTES/CCL5.

21 January 2018

1 reference

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Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction

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The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus

21 January 2018

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Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus

21 January 2018

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A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

21 January 2018

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Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

21 January 2018

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Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus

21 January 2018

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Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.

21 January 2018

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A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort

21 January 2018

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Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis

21 January 2018

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Independent replication and meta analysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis

21 January 2018

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ImmunoChip study implicates antigen presentation to T cells in narcolepsy

21 January 2018

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Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome.

21 January 2018

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CD4+CD25+ T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener's granulomatosis.

21 January 2018

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OX40/OX40L in systemic lupus erythematosus: association with disease activity and lupus nephritis

21 January 2018

1 reference

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Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression

21 January 2018

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Effect of natalizumab on circulating CD4+ T-cells in multiple sclerosis

21 January 2018

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Expression of OX40 (CD134) on CD4+ T-cells from patients with myasthenia gravis

21 January 2018

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High expression of OX40 (CD134) and 4-1BB (CD137) molecules on CD4(+)CD25(high) cells in children with type 1 diabetes.

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Soluble OX40L is associated with presence of autoantibodies in early rheumatoid arthritis

21 January 2018

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Effects of CD134 monoclonal antibody on hemolysis activities and expression of perforin in peripheral blood mononuclear cells of systemic lupus erythematosus patients

21 January 2018

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The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells

21 January 2018

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Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells.

21 January 2018

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IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

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Anti-CD40 Ab- or 8-oxo-dG-enhanced Treg cells reduce development of experimental autoimmune encephalomyelitis via down-regulating migration and activation of mast cells

21 January 2018

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CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.

21 January 2018

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Sjögren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand.

21 January 2018

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CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis

21 January 2018

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T cell-activation in neuromyelitis optica lesions plays a role in their formation.

21 January 2018

1 reference

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CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms.

21 January 2018

1 reference

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Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis

21 January 2018

1 reference

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The role of TNF superfamily members in T-cell function and diseases

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OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

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Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.

21 January 2018

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Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals

21 January 2018

1 reference

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Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment

21 January 2018

1 reference

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Activation of OX40 prolongs and exacerbates autoimmune experimental uveitis

21 January 2018

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CD28-independent induction of experimental autoimmune encephalomyelitis

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OX40L blockade and allergen-induced airway responses in subjects with mild asthma

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OX40 controls islet allograft tolerance in CD154 deficient mice by regulating FOXP3+ Tregs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Ox40L-Ox40 pathway plays distinct roles in regulating Th2 responses but does not determine outcome of cutaneous leishmaniasis caused by Leishmania mexicana and Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Science gone translational: the OX40 agonist story

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Lymphocytic tumor necrosis factor receptor superfamily co-stimulatory molecules in the pathogenesis of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

CD134/OX40 expression by synovial fluid CD4+ T lymphocytes in chronic synovitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Increased Lymphocyte Infiltration in Rheumatoid Arthritis Is Correlated with an Increase in LTi-like Cells in Synovial Fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Analysis of costimulatory molecules OX40/4-1BB (CD134/CD137) detection on chosen mononuclear cells in children and adolescents with Graves' disease during methimazole therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Expression of OX40 and OX40 ligand (gp34) in the normal and myasthenic thymus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Effect of anti-CD134L mAb and CTLA4Ig on ConA-induced proliferation, Th cytokine secretion, and anti-dsDNA antibody production in spleen cells from lupus-prone BXSB mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Characteristics of inflammatory cells in spontaneous autoimmune thyroiditis of NOD.H-2h4 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Characterization of the expanded T-cell populations in patients with Wegener's granulomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12016-015-8498-3

Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Th1/Th2 immune responses are associated with active cutaneous leishmaniasis and clinical cure is associated with strong interferon-gamma production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Expression of OX40 in muscles of polymyositis and granulomatous myopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Synovial fluid OX40T lymphocytes of patients with rheumatoid arthritis display a Th2/Th0 polarization

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Expression and function of OX40 ligand on human dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Evolving strategies for cancer and autoimmunity: back to the future

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

IL-15 controls T cell functions through its influence on CD30 and OX40 antigens in Celiac Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Relationship between OX40/4-1 BB (CD134/CD137) costimulatory molecules expression on T lymphocytes and stimulating and blocking autoantibodies to the TSH-receptor in children with Graves' disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Expression of OX40 ligand in microglia activated by IFN-gamma sustains a protective CD4+ T-cell response in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Flowcytometric study of expression of perforin and CD134 in patients with systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

OX40-OX40L expression in idiopathic inflammatory myopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

OX-40 antibody enhances for autoantigen specific V beta 8.2+ T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac disease, Crohn's disease, ulcerative colitis)

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Altered gene expression in mice with lupus treated with edratide, a peptide that ameliorates the disease manifestations

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Increased OX40 and soluble OX40 ligands in children with Henoch-Schonlein purpura: association with renal involvement

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus: a meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Dynamic change OX40/OX40L mRNA in experimental allergic neuritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

[The role of OX40 in CD4+ T cells cytokines production in ulcerative colitis]

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

OX40 expressed on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: implication for the possible involvement of OX40 in leukemic cell infiltration

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

A replication study from Chinese supports association between lupus-risk allele in TNFSF4 and renal disorder.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

The mRNA expression of pro- and anti-inflammatory cytokines in T regulatory cells in children with type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Increased serum soluble OX40 in patients with systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

CD134 expression on CD4+ T cells is associated with nephritis and disease activity in patients with systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Expressions and clinical significance of OX40 and OX40L in peripheral blood of patients with primary Sjogren's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

T-cell costimulation--biology, therapeutic potential, and challenges

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Altered expression of TNFSF4 and TRAF2 mRNAs in peripheral blood mononuclear cells in patients with systemic lupus erythematosus: association with atherosclerotic symptoms and lupus nephritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Targeting the CD134-CD134L interaction using anti-CD134 and/or rhCD134 fusion protein as a possible strategy to prevent lupus nephritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Analysis of the cellular infiltrate in the iris during experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/26215166

12 December 2020

10.1007/S12016-015-8498-3

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26215166%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 February 2020

1048018629

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26215166%20AND%20SRC:MED&resulttype=core&format=json