New insights on OX40 in the control of T cell immunity and immune tolerance in vivo (Q35685810)

9 August 2017

title

New insights on OX40 in the control of T cell immunity and immune tolerance in vivo (English)

1 reference

9 August 2017

Xiang Xiao

1

1 reference

9 August 2017

Weihua Gong

2

1 reference

9 August 2017

Gulcin Demirci

3

1 reference

9 August 2017

Wentao Liu

4

1 reference

9 August 2017

Silvia Spoerl

5

1 reference

9 August 2017

Xiufeng Chu

6

1 reference

9 August 2017

D Keith Bishop

7

1 reference

9 August 2017

Laurence A Turka

8

1 reference

9 August 2017

Xian C Li

9

1 reference

9 August 2017

language of work or name

English

0 references

publication date

5 December 2011

1 reference

9 August 2017

published in

Journal of Immunology

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9 August 2017

volume

188

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9 August 2017

issue

2

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9 August 2017

page(s)

892-901

1 reference

OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling

9 August 2017

cites work

1 reference

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Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice

12 July 2018

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Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

12 July 2018

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OX40 is required for regulatory T cell-mediated control of colitis

12 July 2018

1 reference

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Control of immunity by the TNFR-related molecule OX40 (CD134)

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right

12 July 2018

1 reference

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

12 July 2018

1 reference

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The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

12 July 2018

1 reference

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OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

OX40 costimulation prevents allograft acceptance induced by CD40-CD40L blockade

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Enhancing SIV-specific immunity in vivo by PD-1 blockade

12 July 2018

1 reference

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T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

The innate natural killer cells in transplant rejection and tolerance induction.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

CD28 costimulation is essential for human T regulatory expansion and function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

OX40 costimulation turns off Foxp3+ Tregs.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

TNF/TNFR family members in costimulation of T cell responses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

The costimulation-regulated duration of PKB activation controls T cell longevity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

12 July 2018

The B7-CD28 superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Immunopharmacology of rapamycin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

OX40 controls functionally different T cell subsets and their resistance to depletion therapy.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262989

A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2

15 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22147766

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22147766

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22147766

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4049/JIMMUNOL.1101373

1 reference

9 August 2017

1 reference

9 August 2017

1 reference