The E3 ligase Itch in immune regulation and beyond. (Q38530613)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26085204%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

review article

1 reference

title

The E3 ligase Itch in immune regulation and beyond (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26085204%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

3

1 reference

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17 February 2020

author name string

Daisuke Aki

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26085204%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Wen Zhang

series ordinal

2

1 reference

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17 February 2020

publication date

1 July 2015

1 reference

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17 February 2020

published in

Immunological Reviews

1 reference

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17 February 2020

volume

266

1 reference

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17 February 2020

issue

1

1 reference

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17 February 2020

page(s)

6-26

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Mechanisms underlying ubiquitination

17 February 2020

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21 January 2018

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21 January 2018

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ATM kinase activity modulates ITCH E3-ubiquitin ligase activity.

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Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIP(L) from degradation by the E3 ligase itch in human melanoma cells

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Immunity, Inflammation, and Cancer

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The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation

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miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops.

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miR-182 as a prognostic marker for glioma progression and patient survival.

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Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity

21 January 2018

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The E3 ubiquitin ligase Itch regulates tumor suppressor protein RASSF5/NORE1 stability in an acetylation-dependent manner

21 January 2018

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HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death

21 January 2018

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Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas

21 January 2018

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High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy

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Itch, an E3 ligase of Oct4, is required for embryonic stem cell self-renewal and pluripotency induction.

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https://api.crossref.org/works/10.1111%2FIMR.12301

WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Ubiquitin e3 ligase itch negatively regulates osteoblast differentiation from mesenchymal progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting deubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

cAMP perturbs inter-Sertoli tight junction permeability barrier in vitro via its effect on proteasome-sensitive ubiquitination of occludin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Expression of Itch in Sertoli cells is controlled via the interaction of E2F1/DP1 complex with E2F and GATA motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Age-dependent alterations in spermatogenesis in itchy mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Recognition mechanism of p63 by the E3 ligase Itch: novel strategy in the study and inhibition of this interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The E3 ubiquitin ligase Itch controls the protein stability of p63

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Various modes of cell death induced by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Itch inhibition regulates chemosensitivity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The ubiquitin-protein ligase Itch regulates p73 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

A regulatory circuit controlling Itch-mediated p73 degradation by Runx.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Caspase cleavage of Itch in chronic lymphocytic leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

TAK1 ubiquitination regulates doxorubicin-induced NF-κB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Signaling in innate immunity and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

A model of partnership co-opted by the homeodomain protein TGIF and the Itch/AIP4 ubiquitin ligase for effective execution of TNF-alpha cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Regulation of NF-κB by deubiquitinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

TGFβ signalling in context

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Regulation of the transforming growth factor β pathway by reversible ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Notch signalling: a simple pathway becomes complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

AIP4/Itch regulates Notch receptor degradation in the absence of ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Numb antagonizes Notch signaling to specify sibling neuron cell fates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Numb regulates post-endocytic trafficking and degradation of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Dual regulation of notch1 signaling pathway by adaptor protein fe65

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Wnt/beta-catenin signaling in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Tissue repair and stem cell renewal in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Hedgehog signaling in development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Filling out the Hippo pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Hippo pathway-independent restriction of TAZ and YAP by angiomotin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

EGF receptor trafficking: consequences for signaling and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Cbl and Itch binding sites in ERBB4 CYT-1 and CYT-2 mediate K48- and K63-polyubiquitination, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The role of chemokines in human immunodeficiency virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

G-protein-coupled receptors and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Itch gene polymorphisms in healthy population and in patients affected by rheumatoid arthritis and atopic dermatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Itch-/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Homeostatic control of regulatory T cell diversity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

The good, the bad and the ugly - TFH cells in human health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12301

21 January 2018

Identifiers

DOI

10.1111/IMR.12301

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26085204%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference