Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins (Q24310048)

positive regulation of protein catabolic process

1 reference

Intercellular adhesion molecule 1

1 reference

CD3 antigen, epsilon polypeptide

1 reference

Casitas B-lineage lymphoma b

1 reference

Neural precursor cell expressed, developmentally down-regulated 4

1 reference

Itchy, E3 ubiquitin protein ligase

1 reference

CD28 antigen

1 reference

Vigo Heissmeyer

1

0 references

Stefan Feske

Stefan Feske

5

0 references

Yun-Cai Liu

Yun-Cai Liu

8

0 references

Sin-Hyeog Im

Sin-Hyeog Im

3

0 references

Michael L Dustin

Michael L Dustin

9

0 references

Anjana Rao

10

Anjana Rao

0 references

author name string

Fernando Macián

2

0 references

Rajat Varma

4

0 references

K Venuprasad

6

0 references

Hua Gu

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

7

0 references

language of work or name

English

0 references

publication date

March 2004

0 references

published in

Nature Immunology

0 references

volume

5

0 references

issue

3

0 references

page(s)

255-65

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Signal transduction and endocytosis: close encounters of many kinds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Partners in transcription: NFAT and AP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Transcriptional mechanisms underlying lymphocyte tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Three-dimensional segregation of supramolecular activation clusters in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

T cell receptor signaling precedes immunological synapse formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

The immunological synapse balances T cell receptor signaling and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Receptor downregulation and multivesicular-body sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Regulation of T cell activation and tolerance by phospholipase C gamma-1-dependent integrin avidity modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Proteome Analysis Reveals Caspase Activation in Hyporesponsive CD4 T Lymphocytes Induced in Vivo by the Oral Administration of Antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

C2-domains, structure and function of a universal Ca2+-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

When cell biology meets development: endocytic regulation of signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Polarity of T cell shape, motility, and sensitivity to antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Fingerprints of anergic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

The small GTPase, Rap1, mediates CD31-induced integrin adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

Molecular interpretation of ERK signal duration by immediate early gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

inferred from DOI database lookup

7 January 2021

based on heuristic

Cblb is a major susceptibility gene for rat type 1 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNI1047

inferred from DOI database lookup

7 January 2021

based on heuristic

Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

1 reference

https://api.crossref.org/works/10.1038%2FNI1047