Pulmonary fibroblasts, an emerging target for anti-obstructive drugs (Q37083259)

18 August 2017

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title

Pulmonary fibroblasts, an emerging target for anti-obstructive drugs (English)

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18 August 2017

Kurt Racké

1

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18 August 2017

Susanne Haag

series ordinal

2

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18 August 2017

Amit Bahulayan

series ordinal

3

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18 August 2017

Mareille Warnken

series ordinal

4

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18 August 2017

publication date

13 February 2008

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Naunyn-Schmiedeberg's Archives of Pharmacology

18 August 2017

published in

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18 August 2017

volume

378

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18 August 2017

issue

2

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18 August 2017

page(s)

193-201

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Long-term carbachol treatment-induced down-regulation of muscarinic M2-receptors but not m2 receptor mRNA in a human lung cell line.

18 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00210-008-0264-0

Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses

21 January 2018

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PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels

21 January 2018

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Modulation of muscarinic-receptor expression in human embryonic lung fibroblasts by platelet-derived growth factor

21 January 2018

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Modulation of collagen production by fibroblasts. Effects of chronic exposure to agonists that increase intracellular cyclic AMP

21 January 2018

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Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA.

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

The role of anticholinergics in chronic obstructive pulmonary disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Anti-leukotriene therapy in asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Airway proteoglycans are differentially altered in fatal asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Prostaglandin E(2) inhibits fibroblast chemotaxis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Lung myofibroblasts as targets of salmeterol and fluticasone propionate: inhibition of alpha-SMA and NF-kappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Fibrocytes in lung disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Long-term Treatment Benefits With Tiotropium in COPD Patients With and Without Short-term Bronchodilator Responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

The airway cholinergic system: physiology and pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

The discovery of potent cRaf1 kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

One-year analysis of longitudinal changes in spirometry in patients with COPD receiving tiotropium

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

MAPK pathway mediates muscarinic receptor-induced human lung fibroblast proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Molecular targets in pulmonary fibrosis: the myofibroblast in focus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Transforming growth factor-beta 1 induces transcriptional down-regulation of m2 muscarinic receptor gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Prostaglandin E receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Role of Epac1 in mediating anti-proliferative effects of prostanoid EP(2) receptors and cAMP in human lung fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

MAPK signal pathways in the regulation of cell proliferation in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/18270687

1 reference

12 December 2020

Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Emerging trends in the therapy of COPD: bronchodilators as mono- and combination therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Innervation of airway smooth muscle. Efferent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Islet-activating protein, pertussis toxin: a specific uncoupler of receptor-mediated inhibition of adenylate cyclase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: expression and function in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Phosphorylation of the Gq/11-coupled m3-muscarinic receptor is involved in receptor activation of the ERK-1/2 mitogen-activated protein kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Nerve supply to the lungs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Search for new cyclic AMP-binding proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Chronic exposure of human cells in culture to the tricyclic antidepressant desipramine reduces the number of beta-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

The MAPK signalling pathways and colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Coupling of M(2) muscarinic receptors to ERK MAP kinases and caldesmon phosphorylation in colonic smooth muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Myofibroblasts and subepithelial fibrosis in bronchial asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

beta-adrenoceptors and potassium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Inhibition of TGF-beta induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Budesonide and formoterol inhibit ICAM-1 and VCAM-1 expression of human lung fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

SUBEPITHELIAL FIBROSIS IN THE BRONCHI OF ASTHMATICS

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alpha1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

A family of cAMP-binding proteins that directly activate Rap1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Mitogenic signaling pathways in airway smooth muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

The role of transforming growth factor beta in lung development and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

The effects of low dose leukotriene receptor antagonist therapy on airway remodeling and cysteinyl leukotriene expression in a mouse asthma model

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Fluticasone and salmeterol downregulate in vitro, fibroblast proliferation and ICAM-1 or H-CAM expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Acetylcholine-induced proliferation of fibroblasts and myofibroblasts in vitro is inhibited by tiotropium bromide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Acetylcholine synthesis and muscarinic receptor subtype mRNA expression in T-lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

TGF-beta signaling and the fibrotic response

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Opposite effect of corticosteroids and long-acting beta(2)-agonists on serum- and TGF-beta(1)-induced extracellular matrix deposition by primary human lung fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Long-acting beta2-agonists in asthma: an overview of Cochrane systematic reviews

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Muscarinic receptors mediate stimulation of human lung fibroblast proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

The myofibroblast: one function, multiple origins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Epac proteins: multi-purpose cAMP targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

A synthetic inhibitor of the mitogen-activated protein kinase cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

A human embryonic lung fibroblast with a high density of muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

G-protein-coupled receptors and cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

The nature of small-airway obstruction in chronic obstructive pulmonary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

EP2 and EP4 prostanoid receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Ultrastructural studies on the neuromuscular control of human tracheal and bronchial muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Muscarinic receptors on intact human fibroblasts. Absence of receptor activity in adult skin cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Contemporary management of chronic obstructive pulmonary disease: scientific review

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Decreased cAMP levels in human diploid cells exposed to cholinergic stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Neuromuscular structure and function in the airways

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Comparison of three radioligands for the labelling of human beta-adrenoceptor subtypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Control by cholinergic mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Chronic obstructive pulmonary disease: histopathology, inflammation and potential therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

The non-neuronal cholinergic system in peripheral blood cells: effects of nicotinic and muscarinic receptor antagonists on phagocytosis, respiratory burst and migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

G-protein-coupled receptors and signaling networks: emerging paradigms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Multiple regulation of adenylyl cyclase activity by G-protein coupled receptors in human foetal lung fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

The non-neuronal cholinergic system in the airways: an unappreciated regulatory role in pulmonary inflammation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Effect of combining salmeterol and fluticasone on the progression of airway remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

Transforming growth factor-beta1 inhibits beta2-adrenoceptor gene transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/18270687

12 December 2020

10.1007/S00210-008-0264-0

Identifiers

DOI

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18 August 2017

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