Regulatable gene expression systems for gene therapy (Q36569912)

15 August 2017

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title

Regulatable gene expression systems for gene therapy (English)

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15 August 2017

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Nuria Vilaboa

1

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15 August 2017

Richard Voellmy

series ordinal

2

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15 August 2017

language of work or name

English

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publication date

1 August 2006

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15 August 2017

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15 August 2017

volume

6

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15 August 2017

issue

4

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15 August 2017

page(s)

421-438

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Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

15 August 2017

cites work

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Steroid and nuclear receptors. Villefranche-sur-Mer, France, May 25-27, 1999.

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https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Modulation of the inflammatory properties and hepatotoxicity of recombinant adenovirus vectors by the viral E4 gene products.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Targeted gene delivery to pulmonary endothelium by anti-PECAM antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Application of membrane-based dendrimer/DNA complexes for solid phase transfection in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Increasing the size of rAAV-mediated expression cassettes in vivo by intermolecular joining of two complementary vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Cell-type specific expression in the pituitary: physiology and gene therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

DNA-polycation nanospheres as non-viral gene delivery vehicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Pre-existing herpes simplex virus 1 (HSV-1) immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A third-generation lentivirus vector with a conditional packaging system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Biodistribution of radiolabeled lipid-DNA complexes and DNA in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Recombinant herpes simplex virus type 1 engineered for targeted binding to erythropoietin receptor-bearing cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Adenovirus-mediated regulable target gene expression in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

The contribution of poly-L-lysine, epidermal growth factor and streptavidin to EGF/PLL/DNA polyplex formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Ligand substitution of receptor targeted DNA complexes affects gene transfer into hepatoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A tetracycline-regulated adenoviral expression system for in vivo delivery of transgenes to lung and liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Adenovirus-mediated expression of human prorelaxin promotes the invasive potential of canine mammary cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Targeted transgene expression in rat brain using lentiviral vectors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Immunogene therapy of recurrent glioblastoma multiforme with a liposomally encapsulated replication-incompetent Semliki forest virus vector carrying the human interleukin-12 gene--a phase I/II clinical protocol.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Manipulation of gene expression by an ecdysone-inducible gene switch in tumor xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: a phase I/II multi-institutional trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: preliminary results of a phase I trial in patients with recurrent malignant gliomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Advances in vector-mediated gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Cell-type-specific and regulatable transgenesis in the adult brain: adenovirus-encoded combined transcriptional targeting and inducible transgene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Differential influence of the E4 adenoviral genes on viral and cellular promoters

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Muscle-specific promoters may be necessary for adeno-associated virus-mediated gene transfer in the treatment of muscular dystrophies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Cocaine-induced expression of the tetraspanin CD81 and its relation to hypothalamic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Quantitative analysis of transgene protein, mRNA, and vector DNA following injection of an adenoviral vector harboring glial cell line-derived neurotrophic factor into the primate caudate nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Gene therapy targeting for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human alpha-fetoprotein promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Pharmacologically regulated gene expression in the retina following transduction with viral vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Gene transfer of vascular endothelial growth factor plasmid/liposome complexes in glioma cells in vitro: the implication for the treatment of cerebral ischemic diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Non-viral vectors in cancer gene therapy: principles and progress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Switching on and off transgene expression within lactotrophic cells in the anterior pituitary gland in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Recombinant AAV-mediated delivery of a tet-inducible reporter gene to the rat retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Development of a FLP/frt system for generating helper-dependent adenoviral vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Adenovirus vectors with the 100K gene deleted and their potential for multiple gene therapy applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Silencing of gene expression: implications for design of retrovirus vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Radio-responsive recA promoter significantly increases TNFalpha production in recombinant clostridia after 2 Gy irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Non-viral, integrin-mediated gene transfer into fibroblasts from patients with lysosomal storage diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Adenovirus-mediated transduction with human glial cell line-derived neurotrophic factor gene prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopamine depletion in striatum of mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Tetracycline-responsive gene expression in mouse brain after amplicon-mediated gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Tetracycline-regulated transgene expression in hippocampal neurones following transfection with adenoviral vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

In vitro gene delivery to hepatocytes with galactosylated polyethylenimine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Viral transactivating proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Fluorescent virions: dynamic tracking of the pathway of adenoviral gene transfer vectors in living cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol)-poly(L-lysine) block copolymer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Evaluation of an autoregulatory tetracycline regulated system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Analysis of immune deviation elicited by antigens injected into the subretinal space.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Two novel adenovirus vector systems permitting regulated protein expression in gene transfer experiments

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Polyethylene glycol-grafted poly-L-lysine as polymeric gene carrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A new non-viral DNA delivery vector: the terplex system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Efficacy of tetracycline-controlled gene expression is influenced by cell type: commentary

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

IL-12 gene therapy using direct injection of tumors with genetically engineered autologous fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Inducible gene expression by retrovirus-mediated transfer of a modified tetracycline-regulated system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A humanized system for pharmacologic control of gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Role of alpha(v) integrins in adenovirus cell entry and gene delivery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

DNA toroids: stages in condensation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Combined ionizing radiation and sKDR gene delivery for treatment of prostate carcinomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Regulated, adenovirus-mediated delivery of tyrosine hydroxylase suppresses growth of estrogen-induced pituitary prolactinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Kinetic modeling of plasmid DNA degradation in rat plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Tightly regulated long-term erythropoietin expression in vivo using tet-inducible recombinant adeno-associated viral vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Intratumoral gene therapy of malignant brain tumor in a rat model with angiostatin delivered by adeno-associated viral (AAV) vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Vigilant vector: heart-specific promoter in an adeno-associated virus vector for cardioprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

High-capacity, helper-dependent, "gutless" adenoviral vectors for gene transfer into brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Murine leukemia induced by retroviral gene marking

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Herpes simplex virus vectors for the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Chitosan and its derivatives--a promising non-viral vector for gene transfection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Evaluation of Tet-on system to avoid transgene down-regulation in ex vivo gene transfer to the CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

The mifepristone-inducible gene regulatory system in mouse models of disease and gene therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Hypothalamic delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and physiological responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Vigilant vectors: adeno-associated virus with a biosensor to switch on amplified therapeutic genes in specific tissues in life-threatening diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A single point mutation in ecdysone receptor leads to increased ligand specificity: implications for gene switch applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Glucose-regulated insulin production in hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Tetracycline-inducible transgene expression mediated by a single AAV vector.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Use of recombinant adenovirus for gene transfer into the rat brain. Evaluation of gene transfer efficiency, toxicity, and inflammatory and immune reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Amplified Muc1-specific gene expression in colon cancer cells utilizing a binary system in adenoviral vectors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Gene delivery using herpes simplex virus vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Tetracycline-regulated gene expression in replication-incompetent herpes simplex virus vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Tetracycline transcriptional silencer tightly controls transgene expression after in vivo intramuscular electrotransfer: application to interleukin 10 therapy in experimental arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Highly suppressible expression of single-chain interleukin-12 by doxycycline following adenoviral infection with a single-vector Tet-regulatory system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Reduced inflammation and improved airway expression using helper-dependent adenoviral vectors with a K18 promoter.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Regulated expression of erythropoietin from an AAV vector safely improves the anemia of beta-thalassemia in a mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Progress and problems with the use of viral vectors for gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Inducible molecular switches for the study of long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Sustained tetracycline-regulated transgene expression in vivo in rat retinal ganglion cells using a single type 2 adeno-associated viral vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Inducible gene expression from defective herpes simplex virus vectors using the tetracycline-responsive promoter system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Novel retroviral vector transferring a suicide gene and a selectable marker gene with enhanced gene expression by using a tetracycline-responsive expression system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Dopaminergic neurons protected from degeneration by GDNF gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

In vitro targeting and specific transfection of human neuroblastoma cells by chCE7 antibody-mediated gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A role for secretory phospholipase A2 and C-reactive protein in the removal of injured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Intracavitary liposome-mediated p53 gene transfer into glioblastoma with endogenous wild-type p53 in vivo results in tumor suppression and long-term survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for ch

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Modification of vascular tone using iNOS under the control of a radiation-inducible promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Lentiviral vectors: regulated gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

pH-sensitive cationic polymer gene delivery vehicle: N-Ac-poly(L-histidine)-graft-poly(L-lysine) comb shaped polymer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Strong promoters are the key to highly efficient, noninflammatory and noncytotoxic adenoviral-mediated transgene delivery into the brain in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

HSV-1 infected cell proteins influence tetracycline-regulated transgene expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Development of multigene and regulated lentivirus vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Nanoscopic structure of DNA condensed for gene delivery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a phase I study in patients with solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A single lentivirus vector mediates doxycycline-regulated expression of transgenes in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Optimal design of a single recombinant adeno-associated virus derived from serotypes 1 and 2 to achieve more tightly regulated transgene expression from nonhuman primate muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Recent advances in the pharmacology of neurological gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

CD81-induced behavioural changes during chronic cocaine administration: in vivo gene delivery with regulatable lentivirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Improving lipoplex-mediated gene transfer into C6 glioma cells and primary neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Delivery of GDNF by an E1,E3/E4 deleted adenoviral vector and driven by a GFAP promoter prevents dopaminergic neuron degeneration in a rat model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Utrophin, a way to cure Duchenne muscle dystrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Use of lentiviral vectors to induce long-term tolerance to gal(+) heart grafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Tight regulation from a single tet-off rAAV vector as demonstrated by flow cytometry and quantitative, real-time PCR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A regulatory system for target gene expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A Phase I trial of TNFerade biologic in patients with soft tissue sarcoma in the extremities

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Mammary Tumor Formation and Hormonal Control of Mouse Mammary Tumor Virus Expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A 46-nucleotide promoter segment from an IFN-alpha gene renders an unrelated promoter inducible by virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Inducible overproduction of the mouse c-myc protein in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

The inducible lac operator-repressor system is functional in mammalian cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Receptor-mediated in vitro gene transformation by a soluble DNA carrier system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Targeting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Direct gene transfer into mouse muscle in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

cis and trans requirements for the selective packaging of adenovirus type 5 DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

In Vivo Expression of β-Galactosidase in Hippocampal Neurons by HSV-Mediated Gene Transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Functional ecdysone receptor is the product of EcR and Ultraspiracle genes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Adenovirus vector-mediated in vivo gene transfer into adult murine retina.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

In vivo transfer of a reporter gene to the retina mediated by an adenoviral vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A regulatory system for use in gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Herpes simplex genes: the blueprint of a successful human pathogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Mechanisms underlying expression of Tn10 encoded tetracycline resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Tetracycline repressor-regulated gene repression in recombinant human cytomegalovirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Herpes simplex virus vector system: analysis of its in vivo and in vitro cytopathic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Gene therapy in peripheral blood lymphocytes and bone marrow for ADA- immunodeficient patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Immunological consequences of HSV-1-mediated gene transfer into the CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Spatial and temporal control of gene therapy using ionizing radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Development and application of herpes simplex virus vectors for human gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Persistence of an [E1-, polymerase-] adenovirus vector despite transduction of a neoantigen into immune-competent mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Sugar-mediated uptake of glycosylated polylysines and gene transfer into normal and cystic fibrosis airway epithelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Inducible genetic suppression of neuronal excitability

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Disease-inducible transgene expression from a recombinant adeno-associated virus vector in a rat arthritis model

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

A single adenovirus vector mediates doxycycline-controlled expression of tyrosine hydroxylase in brain grafts of human neural progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Use of the glucose starvation-inducible glucose-regulated protein 78 promoter in suicide gene therapy of murine fibrosarcoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

Induction of immunity to antigens expressed by recombinant adeno-associated virus depends on the route of administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16918333

12 December 2020

10.2174/156652306777934829

Identifiers

DOI

1 reference

15 August 2017

1 reference