The role of Toll-like receptors in immune disorders (Q36407231)

14 August 2017

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title

The role of Toll-like receptors in immune disorders (English)

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14 August 2017

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1

Satoshi Uematsu

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14 August 2017

Shizuo Akira

2

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14 August 2017

language of work or name

English

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publication date

1 March 2006

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Expert Opinion on Biological Therapy

14 August 2017

published in

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14 August 2017

volume

6

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14 August 2017

issue

3

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14 August 2017

page(s)

203-214

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Innate immune recognition

14 August 2017

cites work

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Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids

21 January 2018

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Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation

21 January 2018

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Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition

21 January 2018

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Immune recognition. A new receptor for beta-glucans

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CD36 is a sensor of diacylglycerides

21 January 2018

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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

21 January 2018

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

21 January 2018

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A toll-like receptor that prevents infection by uropathogenic bacteria

21 January 2018

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TLR11 activation of dendritic cells by a protozoan profilin-like protein.

21 January 2018

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

21 January 2018

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Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets

21 January 2018

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

21 January 2018

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A Toll-like receptor recognizes bacterial DNA

21 January 2018

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Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

21 January 2018

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Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

21 January 2018

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TICAM-1 and TICAM-2: toll-like receptor adapters that participate in induction of type 1 interferons

21 January 2018

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TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling

21 January 2018

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Essential function for the kinase TAK1 in innate and adaptive immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Toll-like receptor signaling

21 January 2018

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

21 January 2018

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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

21 January 2018

1 reference

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Toll-like receptors in the pathogenesis of human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Crohn's disease is associated with a toll-like receptor-9 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Toll-like receptor 4 polymorphism and severity of atopy in asthmatics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

The role of innate immunity in acute allograft rejection after lung transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Modulation of atherosclerosis in mice by Toll-like receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

A frequent toll-like receptor (TLR)-2 polymorphism is a risk factor for coronary restenosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Activation and regulation of Toll-like receptors 2 and 1 in human leprosy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

TLR2 Arg677Trp polymorphism in leprosy: revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case–control disease association studies☆☆This work was supported

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

NLRs join TLRs as innate sensors of pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

The molecular classification of the clinical manifestations of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Pyogenic bacterial infections in humans with IRAK-4 deficiency

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Inherited disorders of human Toll-like receptor signaling: immunological implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Inherited disorders of NF-kappaB-mediated immunity in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Interferons as pathogenic effectors in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Toll-like receptors, endogenous ligands, and systemic autoimmune disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

B-lymphocytes, innate immunity, and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines

21 January 2018

1 reference

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The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells

21 January 2018

1 reference

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Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Triggering the interferon antiviral response through an IKK-related pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Plasmacytoid dendritic cells--virus experts of innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Pleiotropic function of Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

IRF-7 is the master regulator of type-I interferon-dependent immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Cell type-specific involvement of RIG-I in antiviral response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

VISA is an adapter protein required for virus-triggered IFN-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Control of B-cell responses by Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

Toll-like Receptor 4 Polymorphisms and Atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.203

21 January 2018

Identifiers

DOI

10.1517/14712598.6.3.203

1 reference

14 August 2017

1 reference