Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway (Q28216760)

1

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Tsuneyasu Kaisho

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Osamu Takeuchi

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Shintaro Sato

4

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Hideki Sanjo

5

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Katsuaki Hoshino

6

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Takao Horiuchi

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Hideyuki Tomizawa

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Kiyoshi Takeda

Innate immunity: the virtues of a nonclonal system of recognition

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language of work or name

English

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publication date

February 2002

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published in

Nature Immunology

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volume

3

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issue

2

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page(s)

196-200

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cites work

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7 January 2021

Toll-like receptors in the induction of the innate immune response

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Toll-like receptors: critical proteins linking innate and acquired immunity

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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7 January 2021

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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7 January 2021

A Toll-like receptor recognizes bacterial DNA

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7 January 2021

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

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7 January 2021

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

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The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

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7 January 2021

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

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Discrimination of bacterial lipoproteins by Toll-like receptor 6

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7 January 2021

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

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Signaling mechanisms in the antimicrobial host defense of Drosophila

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Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

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7 January 2021

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

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7 January 2021

Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88

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7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

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7 January 2021

Imiquimod applied topically: a novel immune response modifier and new class of drug

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7 January 2021

Cytokine induction by the immunomodulators imiquimod and S-27609

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7 January 2021

Induction of interferon and other cytokines by imiquimod and its hydroxylated metabolite R-842 in human blood cells in vitro

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7 January 2021

Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs

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7 January 2021

Efficacy of S26308 against guinea pig cytomegalovirus infection

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7 January 2021

Daily or weekly therapy with resiquimod (R-848) reduces genital recurrences in herpes simplex virus-infected guinea pigs during and after treatment

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7 January 2021

European course on HPV associated pathology: guidelines for primary care physicians for the diagnosis and management of anogenital warts

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7 January 2021

Bacterial CpG DNA activates immune cells to signal infectious danger.

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7 January 2021

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7 January 2021

CpG motifs in bacterial DNA trigger direct B-cell activation

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7 January 2021

Synthetic Oligonucleotides with Certain Palindromes Stimulate Interferon Production of Human Peripheral Blood Lymphocytes in vitro

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7 January 2021

Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs

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7 January 2021

The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes

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7 January 2021

The immune response modifier resiquimod mimics CD40-induced B cell activation

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7 January 2021

Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848.

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7 January 2021

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

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7 January 2021

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

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7 January 2021

The nature of the principal type 1 interferon-producing cells in human blood

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7 January 2021

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

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7 January 2021

Dendritic cell lineage, plasticity and cross-regulation

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7 January 2021

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

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7 January 2021

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

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7 January 2021

Adjuvant activities of immune response modifier R-848: comparison with CpG ODN

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7 January 2021

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

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7 January 2021

Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction

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7 January 2021