Advances in understanding the pathogenesis of graft-versus-host disease (Q35971439)

11 August 2017

title

Advances in understanding the pathogenesis of graft-versus-host disease. (English)

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11 August 2017

John Magenau

1

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11 August 2017

Lyndsey Runaas

series ordinal

2

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11 August 2017

Pavan Reddy

series ordinal

3

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11 August 2017

language of work or name

English

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publication date

27 March 2016

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British Journal of Haematology

11 August 2017

published in

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11 August 2017

volume

173

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11 August 2017

issue

2

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11 August 2017

page(s)

190-205

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Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration

11 August 2017

cites work

1 reference

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Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

21 January 2018

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Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen

21 January 2018

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Advances in graft-versus-host disease biology and therapy

21 January 2018

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Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts

21 January 2018

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Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation

21 January 2018

1 reference

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Innate immune activation by tissue injury and cell death in the setting of hematopoietic stem cell transplantation

21 January 2018

1 reference

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Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

21 January 2018

1 reference

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IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation

21 January 2018

1 reference

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Current and emerging strategies for the prevention of graft-versus-host disease

21 January 2018

1 reference

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In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia.

21 January 2018

1 reference

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Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial

21 January 2018

1 reference

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Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Siglecs and their roles in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Tocilizumab for the treatment of steroid refractory graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

T-bet is critical for the development of acute graft-versus-host disease through controlling T cell differentiation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal graft-versus-host disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

ST2: the biomarker at the heart of GVHD severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Risk factors for acute GVHD and survival after hematopoietic cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

The Nlrp3 inflammasome regulates acute graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Shift of graft-versus-host-disease target organ tropism by dietary vitamin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Interleukin-2 and regulatory T cells in graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

T-bet: a bridge between innate and adaptive immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Effect of up-front daclizumab when combined with steroids for the treatment of acute graft-versus-host disease: results of a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

HY-Specific Induced Regulatory T Cells Display High Specificity and Efficacy in the Prevention of Acute Graft-versus-Host Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

The best endpoint for acute GVHD treatment trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Next generation treatment of acute graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Neddylation plays an important role in the regulation of murine and human dendritic cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28− CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Mechanisms maintaining peripheral tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Impact of conditioning intensity and TBI on acute GVHD after hematopoietic cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Suppression of inflammation by a synthetic histone mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Discovery and validation of graft-versus-host disease biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

A biomarker panel for acute graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

New perspectives on the biology of acute GVHD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Impact of graft-versus-host disease on survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

High HLA-DP Expression and Graft-versus-Host Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

STAT3 signaling in CD4+ T cells is critical for the pathogenesis of chronic sclerodermatous graft-versus-host disease in a murine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Regulation of acute graft-versus-host disease by microRNA-155.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Decreased serum albumin as a biomarker for severe acute graft-versus-host disease after reduced-intensity allogeneic hematopoietic cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

The impact of graft-versus-host disease prophylaxis in reduced-intensity conditioning allogeneic stem cell transplant in acute myeloid leukemia: a study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

B cells in chronic graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Third-party CD4+ invariant natural killer T cells protect from murine GVHD lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Clinical practice. Alpha1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Current issues in chronic graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

MiR-146a regulates the TRAF6/TNF-axis in donor T cells during GVHD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Allogeneic T cell responses are regulated by a specific miRNA-mRNA network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Mature T cell responses are controlled by microRNA-142.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Interleukin-6 Modulates Graft-versus-Host Responses after Experimental Allogeneic Bone Marrow Transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Influence of donor microbiota on the severity of experimental graft-versus-host-disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic-derived antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Ikaros deficiency in host hematopoietic cells separates GVL from GVHD after experimental allogeneic hematopoietic cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Improved survival after transplantation of more donor plasmacytoid dendritic or naïve T cells from unrelated-donor marrow grafts: results from BMTCTN 0201

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

B7-H3 promotes acute and chronic allograft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

LBH589 enhances T cell activation in vivo and accelerates graft-versus-host disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

Fecal calprotectin and alpha-1 antitrypsin predict severity and response to corticosteroids in gastrointestinal graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBJH.13959

21 January 2018

Identifiers

DOI

10.1111/BJH.13959

1 reference

11 August 2017

1 reference