p53 Family: Role of Protein Isoforms in Human Cancer (Q35326348)

7 August 2017

title

p53 Family: Role of Protein Isoforms in Human Cancer (English)

1 reference

7 August 2017

Jinxiong Wei

1

1 reference

7 August 2017

Elena Zaika

series ordinal

2

1 reference

7 August 2017

Alexander Zaika

series ordinal

3

1 reference

7 August 2017

publication date

9 October 2011

1 reference

7 August 2017

published in

Journal of Nucleic Acids

1 reference

7 August 2017

volume

2012

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7 August 2017

page(s)

687359

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Creative Commons Attribution 3.0 Unported

7 August 2017

copyright license

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer

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p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage

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Characterization of ΔNp73 expression and regulation in gastric and esophageal tumors.

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Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo

27 July 2018

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Phylogeny and function of the invertebrate p53 superfamily

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Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death

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Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors

27 July 2018

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Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

27 July 2018

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p53 regulates the transcription of its Delta133p53 isoform through specific response elements contained within the TP53 P2 internal promoter

27 July 2018

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Expression and clinical significance of S100A2 and p63 in esophageal carcinoma

27 July 2018

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p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence

27 July 2018

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Identification and functional characterization of two new transcriptional variants of the human p63 gene

27 July 2018

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Amphiregulin induces the alternative splicing of p73 into its oncogenic isoform DeltaEx2p73 in human hepatocellular tumors.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p63 antagonizes p53 to promote the survival of embryonic neural precursor cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Cancer-associated regulation of alternative splicing

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Functional characterization of p53beta and p53gamma, two isoforms of the tumor suppressor p53.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Comprehensive mutational analysis and mRNA isoform quantification of TP63 in normal and neoplastic human prostate cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p73 poses a barrier to malignant transformation by limiting anchorage-independent growth

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p73 expression modulates p63 and Mdm2 protein presence in complex with p53 family-specific DNA target sequence in squamous cell carcinogenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p73 supports cellular growth through c-Jun-dependent AP-1 transactivation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p53 family proteins in thyroid cancer.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Expression of p53 isoforms in squamous cell carcinoma of the head and neck

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p63 regulates proliferation and differentiation of developmentally mature keratinocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Prognostic value of increase in transcript levels of Tp73 DeltaEx2-3 isoforms in low-grade glioma patients

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Cytoplasmic localization of p63 is associated with poor patient survival in lung adenocarcinoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

DeltaNp63 protein expression in uterine cervical and endometrial cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

The p53-homologue p63 may promote thyroid cancer progression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Aberrant expression of DeltaNp73 in benign and malignant tumours of the prostate: correlation with Gleason score

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p53 isoforms can regulate p53 transcriptional activity.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Regulation of limbal keratinocyte proliferation and differentiation by TAp63 and DeltaNp63 transcription factors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

DeltaNp63 expression in pancreas and pancreatic neoplasia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p63 overexpression associates with poor prognosis in head and neck squamous cell carcinoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p73 expression for human buccal epithelial dysplasia and squamous cell carcinoma: does it correlate with nodal status of carcinoma and is there a relationship with malignant change of epithelial dysplasia?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p73 isoforms can induce T-cell factor-dependent transcription in gastrointestinal cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Quantitative TP73 transcript analysis in hepatocellular carcinomas.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p63 is the molecular switch for initiation of an epithelial stratification program

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

DeltaNp73beta is active in transactivation and growth suppression.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Does the correlation between EBNA-1 and p63 expression in breast carcinomas provide a clue to tumorigenesis in Epstein-Barr virus-related breast malignancies?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Functional regulation of p73 and p63: development and cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder cancer.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Transactivation-deficient DeltaTA-p73 acts as an oncogene.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Expression of p53 and its homologues in primary and recurrent squamous cell carcinomas of the head and neck

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Differential protein expression, DNA binding and interaction with SV40 large tumour antigen implicate the p63-family of proteins in replicative senescence

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p73 is over-expressed in vulval cancer principally as the Delta 2 isoform

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: a study of 250 cases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

High level expression of deltaN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

AIS is an oncogene amplified in squamous cell carcinoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Analysis of p73 in human borderline and invasive ovarian tumor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

The expression of p73 is increased in lung cancer, independent of p53 gene alteration

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Mutational analysis of p51A/TAp63gamma, a p53 homolog, in non-small cell lung cancer and breast cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p63 is a p53 homologue required for limb and epidermal morphogenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

T antigen is bound to a host protein in SY40-transformed cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Alternative isoform regulation in human tissue transcriptomes

27 July 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Multiple alternative splicing markers for ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

The role of p63 in germ cell apoptosis in the developing testis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

p73: in silico evidence for a putative third promoter region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

P63 and P73: P53 mimics, menaces and more

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Alternative splicing of p53 and p73: the novel p53 splice variant p53delta is an independent prognostic marker in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoform.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Modulation of mammalian life span by the short isoform of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Autonomous growth and hepatocarcinogenesis in transgenic mice expressing the p53 family inhibitor DNp73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

DeltaTAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Alterations of DeltaTA-p 73 splice transcripts during melanoma development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Clinical relevance of the putative stem cell marker p63 in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Expression of deltaNp73 predicts poor prognosis in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

A lack of prognostic significance regarding DeltaNp63 immunoreactivity in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Aberrant cytoplasmic expression of p63 and prostate cancer mortality

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

The role of p63 and ΔNp63 (p40) protein expression and gene amplification in esophageal carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

p53 family members in myogenic differentiation and rhabdomyosarcoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Clinical relevance of dominant-negative p73 isoforms for responsiveness to chemotherapy and survival in ovarian cancer: evidence for a crucial p53-p73 cross-talk in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

p63 gene expression study and early bladder carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

TAp63 induces senescence and suppresses tumorigenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

[The expression of p63 gene in human non-small cell lung cancer].

21 January 2018

1 reference

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Expression of p53 isoforms in renal cell carcinoma.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Different intracellular compartmentalization of TA and DeltaNp73 in non-small cell lung cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Expression of the p53 family in lung cancer.

26 September 2018

1 reference

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Reduced expression of p63 has prognostic implications for patients with esophageal squamous cell carcinoma.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Deregulation of p73 isoform equilibrium in benign prostate hyperplasia and prostate cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Significance of p63 amplification and overexpression in lung cancer development and prognosis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191818

Global DNA hypomethylation-induced ΔNp73 transcriptional activation in non-small cell lung cancer

26 September 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

ΔNp63 expression is associated with poor survival in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F687359

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

21 January 2018

2 references

https://api.crossref.org/works/10.1155%2F2012%2F687359

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

New p73 variants with altered C-terminal structures have varied transcriptional activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Frequent alteration of p63 expression in human primary bladder carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Differential expression of p73 isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

p73 mutations are not detected in sporadic and hereditary breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Expression of TAp73 and DeltaNp73 isoform transcripts in thyroid tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Expression of the p53 homologues p63 and p73 in multiple simultaneous gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

p73 Overexpression and angiogenesis in human colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Delta Np73 expression in thyroid neoplasms originating from follicular cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Overexpression of the wild type p73 gene in human bladder cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Loss of imprinting and allele switching of p73 in renal cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Overexpression of the wild type p73 gene in breast cancer tissues and cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Elevated and biallelic expression of p73 is associated withprogression of human bladder cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Mutation and expression analysis of the p73 gene in prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

p63 expression in breast cancer: a highly sensitive and specific marker of metaplastic carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

p63 and p73 isoform expression in non-small cell lung cancer and corresponding morphological normal lung tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Enhanced p73 expression during differentiation and complex p73 isoforms in myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Oncogenes induce and activate endogenous p73 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

[Different expressions of p53 gene family members and their clinical significance in human non-small cell lung cancer]

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Expression of deltaNp63 in squamous cell carcinoma of the esophagus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Mutational analysis of the p73 gene in human breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Diagnostic and prognostic impact of p63 immunoreactivity in renal malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

TAp73 Is a Downstream Target of p53 in Controlling the Cellular Defense against Stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Expression of p73 and p63 proteins in pancreatic adenocarcinoma: p73 overexpression is inversely correlated with biological aggressiveness

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Role of methylation in the control of DeltaNp73 expression in neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Immunohistochemical expression of p16, p53, and p63 in colorectal adenomas and adenocarcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Expression of deltaNp73 and TAp73alpha independently associated with radiosensitivities and prognoses in cervical squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Loss of expression or mutations in the p73 tumour suppressor gene are not involved in the pathogenesis of malignant melanomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

p73 is transcriptionally regulated by DNA damage, p53, and p73

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

P634A4 and TAp73 immunocytochemistry in liquid-based cervical cytology--potential biomarkers for diagnosis and progress prediction of cervical neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22007292

12 December 2020

Identifiers

DOI

10.1155/2012/687359

1 reference

7 August 2017

1 reference

7 August 2017

1 reference