Delivering the kiss of death (Q35116674)

6 August 2017

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title

Delivering the kiss of death (English)

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6 August 2017

2

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6 August 2017

Christina M Trambas

1

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6 August 2017

language of work or name

English

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publication date

1 May 2003

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6 August 2017

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6 August 2017

volume

4

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6 August 2017

issue

5

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6 August 2017

page(s)

399-403

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Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Homology of perforin to the ninth component of complement (C9).

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Functional size of complement and perforin pores compared by confocal laser scanning microscopy and fluorescence microphotolysis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Lymphocyte mediated cytolysis as a secretory phenomenon

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

A natural killer cell granule protein that induces DNA fragmentation and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Cytotoxic T lymphocytes: all roads lead to death

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Internalization of blocking antibodies against mannose-6-phosphate specific receptors

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Perforin-Enhancing Protein, a Low Molecular Weight Protein of Cytotoxic Lymphocyte Granules, Enhances Perforin Lysis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Motoring around the Golgi

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

The immunological synapse of CTL contains a secretory domain and membrane bridges.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Formation and function of the immunological synapse

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Role of calcium influx in cytotoxic T lymphocyte lytic granule exocytosis during target cell killing

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Identification of the murine beige gene by YAC complementation and positional cloning

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

A mutation in Rab27a causes the vesicle transport defects observed in ashen mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Albinism and immunity: what's the link?

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Regulated secretion from hemopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Rab27a is required for regulated secretion in cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Rab27a regulates the peripheral distribution of melanosomes in melanocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Rab27a is an essential component of melanosome receptor for myosin Va

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Two genes are responsible for Griscelli syndrome at the same 15q21 locus.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Interaction of a Golgi-associated kinesin-like protein with Rab6

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Late endosome motility depends on lipids via the small GTPase Rab7.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Analysis of the lysosomal storage disease Chediak-Higashi syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Identification of the homologous beige and Chediak-Higashi syndrome genes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Secretory Lysosome Biogenesis in Cytotoxic T Lymphocytes from Normal and Chediak Higashi Syndrome Patients

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

The role of cytotoxicity in lymphocyte homeostasis.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Haemophagocytic lymphohistiocytosis: proposal of a diagnostic algorithm based on perforin expression

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Perforin defects of primary haemophagocytic lymphohistiocytosis in Japan

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Perforin: more than just an effector molecule

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

On the pathogenesis of perforin defects and related immunodeficiencies

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Immune function in mice lacking the perforin gene

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Homeostatic regulation of CD8+ T cells by perforin

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Cognate peptides induce self-destruction of CD8+ cytolytic T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

TCR-Mediated internalization of peptide-MHC complexes acquired by T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

B cells acquire antigen from target cells after synapse formation

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Acquisition of external major histocompatibility complex class I molecules by natural killer cells expressing inhibitory Ly49 receptors

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Active trans-synaptic capture of membrane fragments by natural killer cells.

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Synaptic transfer by human gamma delta T cells stimulated with soluble or cellular antigens

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Cutting edge: CTLs rapidly capture membrane fragments from target cells in a TCR signaling-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FNI0503-399

7 January 2021

Identifiers

DOI

10.1038/NI0503-399

1 reference

6 August 2017

1 reference