Novel drugs targeting Toll-like receptors for antiviral therapy (Q34999938)

25620999

5 August 2017

title

Novel drugs targeting Toll-like receptors for antiviral therapy (English)

1 reference

5 August 2017

0 references

7

1 reference

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1 June 2020

4

Marina S Boukhvalova

1 reference

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1 June 2020

6

Stefanie N Vogel

1 reference

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1 June 2020

3

Lioubov M Pletneva

1 reference

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1 June 2020

2

Kari Ann Shirey

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1 June 2020

1

Mira C Patel

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1 June 2020

author name string

Alfredo Garzino-Demo

series ordinal

5

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1 June 2020

publication date

1 September 2014

1 reference

5 August 2017

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1 June 2020

volume

9

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1 June 2020

issue

9

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1 June 2020

page(s)

811-829

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A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction

1 June 2020

cites work

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Toll-like receptors in antiviral innate immunity

8 July 2018

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A recombinant anchorless respiratory syncytial virus (RSV) fusion (F) protein/monophosphoryl lipid A (MPL) vaccine protects against RSV-induced replication and lung pathology.

8 July 2018

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Rotavirus NSP4 Triggers Secretion of Proinflammatory Cytokines from Macrophages via Toll-Like Receptor 2.

8 July 2018

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TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns

8 July 2018

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The TLR4 antagonist Eritoran protects mice from lethal influenza infection

8 July 2018

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Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial

8 July 2018

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Regulation of HMGB1 release by inflammasomes

8 July 2018

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GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees

8 July 2018

1 reference

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Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9.

8 July 2018

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Suppression of TLR signaling by targeting TIR domain-containing proteins

8 July 2018

1 reference

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Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice

8 July 2018

1 reference

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Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis

8 July 2018

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Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections

8 July 2018

1 reference

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Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2.

8 July 2018

1 reference

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Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

8 July 2018

1 reference

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TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification

8 July 2018

1 reference

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Protective role of Toll-like Receptor 3-induced type I interferon in murine coronavirus infection of macrophages.

8 July 2018

1 reference

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θ-Defensins: cyclic peptides with endless potential

8 July 2018

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Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility

8 July 2018

1 reference

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Herpes simplex virus glycoproteins gH/gL and gB bind Toll-like receptor 2, and soluble gH/gL is sufficient to activate NF-κB

8 July 2018

1 reference

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TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice

8 July 2018

1 reference

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CpG still rocks! Update on an accidental drug

8 July 2018

1 reference

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R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes

8 July 2018

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Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

8 July 2018

1 reference

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B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K

8 July 2018

1 reference

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Role of specific innate immune responses in herpes simplex virus infection of the central nervous system

8 July 2018

1 reference

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CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

8 July 2018

1 reference

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The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice

8 July 2018

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Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

8 July 2018

1 reference

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Pattern recognition receptors and the innate immune response to viral infection

8 July 2018

1 reference

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Innate immune sensing of retroviral infection via Toll-like receptor 7 occurs upon viral entry

8 July 2018

1 reference

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Randomised clinical trial: anti-viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV.

8 July 2018

1 reference

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Use of modelling and simulation techniques to support decision making on the progression of PF-04878691, a TLR7 agonist being developed for hepatitis C

8 July 2018

1 reference

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Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

8 July 2018

1 reference

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The control of adaptive immune responses by the innate immune system

8 July 2018

1 reference

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Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems

8 July 2018

1 reference

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Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway

8 July 2018

1 reference

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Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium

8 July 2018

1 reference

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Toll-like receptor (TLR) 2 and TLR9 expressed in trigeminal ganglia are critical to viral control during herpes simplex virus 1 infection

8 July 2018

1 reference

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Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule

8 July 2018

1 reference

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TLR-based immune adjuvants.

8 July 2018

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New insights for development of a safe and protective RSV vaccine

8 July 2018

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Recent insights into the role of Toll-like receptors in viral infection

8 July 2018

1 reference

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Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA

8 July 2018

1 reference

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Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection.

8 July 2018

1 reference

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Activation of interferon response through toll-like receptor 3 impacts viral pathogenesis and pulmonary toll-like receptor expression during respiratory syncytial virus and influenza infections in the cotton rat Sigmodon hispidus model

8 July 2018

1 reference

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FSL-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental HSV-2 infection

8 July 2018

1 reference

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Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo

8 July 2018

1 reference

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AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity

8 July 2018

1 reference

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Interaction between Ebola virus glycoprotein and host toll-like receptor 4 leads to induction of proinflammatory cytokines and SOCS1.

8 July 2018

1 reference

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Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

8 July 2018

1 reference

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Toll-like receptor 7-induced immune response to cutaneous West Nile virus infection

8 July 2018

1 reference

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Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

8 July 2018

1 reference

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Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1.

8 July 2018

1 reference

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A cell biological view of Toll-like receptor function: regulation through compartmentalization.

8 July 2018

1 reference

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Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.

8 July 2018

1 reference

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Antiviral role of toll-like receptor-3 agonists against seasonal and avian influenza viruses

8 July 2018

1 reference

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

8 July 2018

1 reference

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Hantaan virus triggers TLR3-dependent innate immune responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Toll-like Receptor 7 Mitigates Lethal West Nile Encephalitis via Interleukin 23-Dependent Immune Cell Infiltration and Homing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic.

8 July 2018

1 reference

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Human TLR3 recognizes dengue virus and modulates viral replication in vitro

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Respiratory syncytial virus activates innate immunity through Toll-like receptor 2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Viral evasion and subversion of pattern-recognition receptor signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

CpG oligonucleotides enhance proliferative and effector responses of B Cells in HIV-infected individuals

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Single-stranded oligonucleotides can inhibit cytokine production induced by human toll-like receptor 3.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

The antiviral activity of Toll-like receptor 7 and 7/8 agonists

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

TLR3: interferon induction by double-stranded RNA including poly(I:C).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

TLR3 increases disease morbidity and mortality from vaccinia infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

TLR3 deficiency in patients with herpes simplex encephalitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Cooperation of Toll-like receptor signals in innate immune defence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

TLR3 deletion limits mortality and disease severity due to Phlebovirus infection.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of IL-1beta or activation of caspase-1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

The evolution of vertebrate Toll-like receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Toll-like receptor signaling inhibits hepatitis B virus replication in vivo.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Respiratory syncytial virus and other pneumoviruses: a review of the international symposium--RSV 2003.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Vaccine adjuvants: current state and future trends

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Toll-like receptor signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

A toll-like receptor that prevents infection by uropathogenic bacteria

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Murine retroviruses activate B cells via interaction with toll-like receptor 4

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

E5531, a pure endotoxin antagonist of high potency

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Approaching the asymptote? Evolution and revolution in immunology

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Diphosphoryl lipid A obtained from the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides is an endotoxin antagonist in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury

8 July 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

The history of Toll-like receptors - redefining innate immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

TLR2 and TLR9 synergistically control herpes simplex virus infection in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Vaccine-enhanced respiratory syncytial virus disease in cotton rats following immunization with Lot 100 or a newly prepared reference vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Monophosphoryl lipid A adjuvant reverses a principal histologic parameter of formalin-inactivated respiratory syncytial virus vaccine-induced disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

The TLR4 agonist, monophosphoryl lipid A, attenuates the cytokine storm associated with respiratory syncytial virus vaccine-enhanced disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Efficacy and safety of an intranasal virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice and cotton rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Interferon-α suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Vaccines for the twenty-first century society.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Purification and structural determination of nontoxic lipid A obtained from the lipopolysaccharide of Salmonella typhimurium.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon

26 October 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Potent immune activation in chronic hepatitis C patients upon administration of an oral inducer of endogenous interferons that acts via Toll-like receptor 7

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Cutting Edge: Overlapping Functions of TLR7 and TLR9 for Innate Defense against a Herpesvirus Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFVL.14.70

Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4303062

Single-stranded DNA oligonucleotides inhibit TLR3-mediated responses in human monocyte-derived dendritic cells and in vivo in cynomolgus macaques

9 December 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25620999

12 December 2020

PIKA as an adjuvant enhances specific humoral and cellular immune responses following the vaccination of mice with HBsAg plus PIKA

1 reference

https://pubmed.ncbi.nlm.nih.gov/25620999

12 December 2020

Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system

1 reference

https://pubmed.ncbi.nlm.nih.gov/25620999

12 December 2020

2'-O-methyl-modified RNAs act as TLR7 antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/25620999

12 December 2020

Toll-like receptors and innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/25620999

12 December 2020

Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers

1 reference

https://pubmed.ncbi.nlm.nih.gov/25620999

12 December 2020

Safety, pharmacokinetics and immune effects in normal volunteers of CPG 10101 (ACTILON), an investigational synthetic toll-like receptor 9 agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/25620999

12 December 2020

Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/25620999

12 December 2020

Development of TLR7/8 small RNA antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/25620999

12 December 2020

Identifiers

DOI

10.2217/FVL.14.70

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25620999%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25620999%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

25620999

1 reference