Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1 (Q34430583)

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13 February 2020

title

Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1 (English)

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13 February 2020

6

1 reference

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13 February 2020

Marcel B Bally

8

1 reference

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13 February 2020

author name string

J Kalra

1

1 reference

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13 February 2020

B W Sutherland

2

1 reference

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13 February 2020

A L Stratford

3

1 reference

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13 February 2020

W Dragowska

4

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13 February 2020

K A Gelmon

5

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13 February 2020

S E Dunn

7

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13 February 2020

language of work or name

English

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publication date

13 September 2010

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13 February 2020

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13 February 2020

volume

29

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13 February 2020

issue

48

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13 February 2020

page(s)

6343-6356

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Role of microtubules in stress granule assembly: microtubule dynamical instability favors the formation of micrometric stress granules in cells.

13 February 2020

cites work

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Nuclear Y-box binding protein-1, a predictive marker of prognosis, is correlated with expression of HER2/ErbB2 and HER3/ErbB3 in non-small cell lung cancer

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siRNA-mediated integrin-linked kinase suppression: nonspecific effects of siRNA/cationic liposome complexes trigger changes in the expression of phosphorylated-AKT and mTOR independently of ILK silencing

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TWIST-1 is overexpressed in neoplastic choroid plexus epithelial cells and promotes proliferation and invasion

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Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells

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Integrin-linked kinase--essential roles in physiology and cancer biology.

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YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubules

6 July 2018

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Epithelial-mesenchymal transition markers in pancreatic ductal adenocarcinoma

6 July 2018

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Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence

6 July 2018

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Twist is required for thrombin-induced tumor angiogenesis and growth

6 July 2018

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Twist and p53 reciprocally regulate target genes via direct interaction

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Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function

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6 July 2018

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Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathway

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance

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Treatment of HER-2/neu overexpressing breast cancer xenograft models with trastuzumab (Herceptin) and gefitinib (ZD1839): drug combination effects on tumor growth, HER-2/neu and epidermal growth factor receptor expression, and viable hypoxic cell fr

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Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.

6 July 2018

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ILKAP regulates ILK signaling and inhibits anchorage-independent growth

6 July 2018

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Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid

6 July 2018

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Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis

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The role of integrin-linked kinase (ILK) in cancer progression

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The pleiotropic functions of the Y-box-binding protein, YB-1.

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Insulin-like growth factor 1 (IGF-1)-induced twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor

6 July 2018

1 reference

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Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

6 July 2018

1 reference

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Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner

6 July 2018

1 reference

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Twist is a potential oncogene that inhibits apoptosis

6 July 2018

1 reference

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

6 July 2018

1 reference

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Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15.5-p15.4

6 July 2018

1 reference

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Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression

6 July 2018

1 reference

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MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer.

6 July 2018

1 reference

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Isolation and characterization of a cDNA clone for the CCAAT transcription factor EFIA reveals a novel structural motif

6 July 2018

1 reference

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Phosphorylation by Akt disables the anti-oncogenic activity of YB-1.

6 July 2018

1 reference

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YB-1 provokes breast cancer through the induction of chromosomal instability that emerges from mitotic failure and centrosome amplification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

Integrin-linked kinase (ILK) expression in human colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

Twist promotes tumor cell growth through YB-1 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

TWIST1 overexpression is associated with nodal invasion and male sex in primary colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xe

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

Expression of twist and wnt in human breast cancer.

21 January 2018

1 reference

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Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival.

27 October 2018

1 reference

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Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007675

Integrin-linked kinase expression increases with prostate tumor grade

27 October 2018

1 reference

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Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB-1 and PABP

27 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2α

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: their correlation with activated Akt, LRP/MVP and P-glycoprotein expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

A hypoxic twist in metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

P50/YB-1, a major protein of cytoplasmic mRNPs, regulates its own synthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.366

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.366

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20838384%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20838384%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

20838384

1 reference