System xc⁻ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS. (Q34184493)

31 July 2017

1 reference

title

System xc⁻ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS. (English)

1 reference

31 July 2017

1 reference

Richard J Bridges

1

1 reference

31 July 2017

Nicholas R Natale

series ordinal

2

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31 July 2017

Sarjubhai A Patel

series ordinal

3

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31 July 2017

language of work or name

English

0 references

publication date

1 January 2012

1 reference

British Journal of Pharmacology

31 July 2017

published in

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31 July 2017

volume

165

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31 July 2017

issue

1

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31 July 2017

page(s)

20-34

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Glial solute carrier transporters in Drosophila and mice

31 July 2017

cites work

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Synthesis and preliminary pharmacological evaluation of novel derivatives of L-beta-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Mapping of glutathione and its precursor amino acids reveals a role for GLYT2 in glycine uptake in the lens core

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc-.

5 July 2018

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Regional differences in cystine accumulation point to a sutural delivery pathway to the lens core

5 July 2018

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5 July 2018

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Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo

5 July 2018

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5 July 2018

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Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation.

5 July 2018

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5 July 2018

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Oxidative stress and neurodegeneration: where are we now?

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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The genetics of heteromeric amino acid transporters

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

5 July 2018

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The origin and neuronal function of in vivo nonsynaptic glutamate.

5 July 2018

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Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

5 July 2018

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The light subunit of system b(o,+) is fully functional in the absence of the heavy subunit

5 July 2018

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Structure-function relationships of heterodimeric amino acid transporters

5 July 2018

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Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment

5 July 2018

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Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function.

5 July 2018

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Ligands for glutamate receptors: design and therapeutic prospects

5 July 2018

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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

5 July 2018

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Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange

5 July 2018

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Glioma cells release excitotoxic concentrations of glutamate.

5 July 2018

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Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins

5 July 2018

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Functional studies in cultured astrocytes

5 July 2018

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Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione

5 July 2018

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5 July 2018

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5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Interaction of L-cysteine with a human excitatory amino acid transporter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Induction of cystine transport activity in mouse peritoneal macrophages by bacterial lipopolysaccharide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Induction of cystine and glutamate transport activity in human fibroblasts by diethyl maleate and other electrophilic agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

The Ca2+/C1- dependent L-[3H]glutamate binding: a new receptor or a particular transport process?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Improved tools for biological sequence comparison

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

A comparison of 2-amino-4-phosphonobutyric acid (AP4) receptors and [3H]AP4 binding sites in the rat brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Calcium-dependent and -independent release of glutamate from synaptosomes monitored by continuous fluorometry

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Use of cystine to distinguish glutamate binding from glutamate sequestration.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Induction of cystine transport activity in human fibroblasts by oxygen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Mechanisms of induction of enzymes that protect against chemical carcinogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Characterization of L-glutamic acid transport by glioma cells in culture: evidence for sodium-independent, chloride-dependent high affinity influx

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

A L-[3H]glutamate binding site on glia: an autoradiographic study on implanted astrocytes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Uptake of glutamate and cysteine in C-6 glioma cells and in cultured astrocytes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Characterization of the cystine/glutamate transporter in the outer plexiform layer of the vertebrate retina

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Glutathione depletion activates mitogen-activated protein kinase (MAPK) pathways that display organ-specific responses and brain protection in mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Policing the police: astrocytes modulate microglial activation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Interleukin-1beta potentiates neuronal injury in a variety of injury models involving energy deprivation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Dynamics of sulfur amino acids in mammalian brain: assessment of the astrocytic-neuronal cysteine interaction by a mathematical hybrid model

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Inhibition of non‐vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Cerebral cystine uptake: a tale of two transporters

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

L-Quisqualic acid transport into hippocampal neurons by a cystine-sensitive carrier is required for the induction of quisqualate sensitization.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Glutamate release promotes growth of malignant gliomas

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Dibutyryl-cAMP (dbcAMP) up-regulates astrocytic chloride-dependent L-[3H]glutamate transport and expression of both system xc(-) subunits

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252963

Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation

28 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21564084

12 December 2020

Exchange of cystine and glutamate across plasma membrane of human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21564084

12 December 2020

Cystine/glutamate antiporter expression in retinal Müller glial cells: implications for DL-alpha-aminoadipate toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21564084

12 December 2020

Role of proton dissociation in the transport of cystine and glutamate in human diploid fibroblasts in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/21564084

12 December 2020

Regulation of the system x(C)- cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/21564084

12 December 2020

Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/21564084

12 December 2020

System x(c)- activity and astrocytes are necessary for interleukin-1 beta-mediated hypoxic neuronal injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/21564084

12 December 2020

Maintenance of neuronal glutathione by glial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21564084

12 December 2020

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/21564084

12 December 2020

Astrocytes provide cysteine to neurons by releasing glutathione

1 reference

https://pubmed.ncbi.nlm.nih.gov/21564084

12 December 2020

Expression profiling identifies a molecular signature of reactive astrocytes stimulated by cyclic AMP or proinflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21564084

12 December 2020

10.1111/J.1476-5381.2011.01480.X

Identifiers

DOI

1 reference

31 July 2017

1 reference

31 July 2017

1 reference