Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family (Q34158166)

31 July 2017

1 reference

title

Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family (English)

1 reference

31 July 2017

0 references

Michael U Martin

1

1 reference

31 July 2017

Holger Wesche

series ordinal

2

1 reference

31 July 2017

language of work or name

English

0 references

publication date

1 November 2002

1 reference

Biochimica et Biophysica Acta

31 July 2017

published in

1 reference

31 July 2017

volume

1592

1 reference

31 July 2017

issue

3

1 reference

31 July 2017

page(s)

265-280

1 reference

The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense

31 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Primitive Toll signalling: bugs, flies, worms and man.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Purification and characterization of the human interleukin-18 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Identification and initial characterization of four novel members of the interleukin-1 family

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Four new members expand the interleukin-1 superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Annotating genes with potential roles in the immune system: six new members of the IL-1 family

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Toll-like receptors: critical proteins linking innate and acquired immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Toll-like receptors as sensors of pathogens

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The Pto Bacterial Resistance Gene and the Fen Insecticide Sensitivity Gene Encode Functional Protein Kinases with Serine/Threonine Specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Toll-like receptors in the induction of the innate immune response

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Cinderella goes to the ball

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

A Toll-like receptor recognizes bacterial DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Essay 1: the Danger model in its historical context

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Recognition of gram-negative bacteria and endotoxin by the innate immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

A family of human receptors structurally related to Drosophila Toll

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma : a molecular basis for priming and synergism with bacterial lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

TIRAP: an adapter molecule in the Toll signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Macrophage differentiation marker MyD88 is a member of the Toll/IL-1 receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Genetic structure and chromosomal mapping of MyD88

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The cloning and characterization of human MyD88: a member of an IL-1 receptor related family

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Model of interaction of the IL-1 receptor accessory protein IL-1RAcP with the IL-1beta/IL-1R(I) complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1Rrp1 leads to activation of signaling pathways similar to those used by interleukin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Targeting interleukin 18 with interleukin 18 binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Fluorescence resonance energy transfer reveals interleukin (IL)-1-dependent aggregation of IL-1 type I receptors that correlates with receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

1 reference

7 January 2021

Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The molecular mechanism of B cell activation by toll-like receptor protein RP-105

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The smallest known non-avian theropod dinosaur

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

MyD88, an adapter protein involved in interleukin-1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Interleukin-1-induced activation of a protein kinase co-precipitating with the type I interleukin-1 receptor in T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

IRAK: a kinase associated with the interleukin-1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Three-dimensional structure of a complex between the death domains of Pelle and Tube

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

TRAF6 is a signal transducer for interleukin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Mammalian MAP kinase signalling cascades

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Negative regulation of toll-like receptor-mediated signaling by Tollip

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Endotoxin-induced maturation of MyD88-deficient dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The apoptotic signaling pathway activated by Toll-like receptor-2

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The recruitment of the interleukin-1 (IL-1) receptor-associated kinase (IRAK) into focal adhesion complexes is required for IL-1beta -induced ERK activation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Ras controls tumor necrosis factor receptor-associated factor (TRAF)6-dependent induction of nuclear factor-kappa b. Selective regulation through receptor signaling components

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Regulation by rho family GTPases of IL-1 receptor induced signaling: C3-like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL-2 gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Synergistic activation of JNK/SAPK by interleukin-1 and platelet-derived growth factor is independent of Rac and Cdc42.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The IL-1 receptor and Rho directly associate to drive cell activation in inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Acid sphingomyelinase-derived ceramide is not required for inflammatory cytokine signalling in murine macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Interleukin 1 beta (IL-1 beta) action in porcine thyroid cells involves the ceramide signalling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Role of the protein kinase C lambda/iota isoform in nuclear factor-kappaB activation by interleukin-1beta or tumor necrosis factor-alpha: cell type specificities

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating NF-kappa B activation in response to tumor necrosis factor-alpha and interleukin-1beta

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Interleukin 1-beta-induced protein kinase C-zeta activation is mimicked by exogenous phospholipase D.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

The role of neutrophil-derived oxidants as second messengers in interleukin 1beta-stimulated cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Protein kinase calpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1beta: involvement of sequential activation of tyrosine k

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Induction of COX-2 and PGE(2) biosynthesis by IL-1beta is mediated by PKC and mitogen-activated protein kinases in murine astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Dual specificity of the interleukin 1- and tumor necrosis factor-activated beta casein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4889%2802%2900320-8

7 January 2021

10.1016/S0167-4889(02)00320-8

Identifiers

DOI

1 reference

31 July 2017

1 reference