EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis (Q34117589)

31 July 2017

title

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis (English)

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31 July 2017

1 reference

Christopher G Duncan

5

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Matthew L Hedberg

Matthew L Hedberg

10

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Frank B Furnari

Frank B Furnari

23

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Darell D. Bigner

21

Darell D Bigner

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31 July 2017

20

Roger E McLendon

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31 July 2017

Jennifer Rubin Grandis

19

Jennifer R Grandis

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31 July 2017

1

Haizhong Feng

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31 July 2017

4

Angel Alvarez

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31 July 2017

24

Webster K Cavenee

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31 July 2017

25

Bo Hu

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31 July 2017

27

Shi-Yuan Cheng

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31 July 2017

Giselle Y Lopez

2

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31 July 2017

Chung Kwon Kim

3

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31 July 2017

Ryo Nishikawa

6

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31 July 2017

Motoo Nagane

7

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31 July 2017

An-Jey A Su

8

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31 July 2017

Philip E Auron

9

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31 July 2017

Lin Wang

11

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31 July 2017

Jeffery J Raizer

12

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31 July 2017

John A Kessler

13

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31 July 2017

Andrew T Parsa

14

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31 July 2017

Wei-Qiang Gao

15

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31 July 2017

Sung-Hak Kim

16

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31 July 2017

Mutsuko Minata

17

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31 July 2017

Ichiro Nakano

18

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31 July 2017

Hui-Kuan Lin

22

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31 July 2017

Hai Yan

26

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31 July 2017

language of work or name

English

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publication date

25 July 2014

1 reference

Journal of Clinical Investigation

31 July 2017

published in

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31 July 2017

volume

124

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31 July 2017

issue

9

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31 July 2017

page(s)

3741-3756

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Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.

31 July 2017

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.

5 July 2018

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P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3.

5 July 2018

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Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

5 July 2018

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5 July 2018

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Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

5 July 2018

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TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer

5 July 2018

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Platelet-derived growth factor receptor alpha in glioma: a bad seed

5 July 2018

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SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans

5 July 2018

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Hallmarks of Cancer: The Next Generation

5 July 2018

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Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations

5 July 2018

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5 July 2018

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5 July 2018

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Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

5 July 2018

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TRAF6 is autoinhibited by an intramolecular interaction which is counteracted by trans-ubiquitination

5 July 2018

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Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma

5 July 2018

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ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain

5 July 2018

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

5 July 2018

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The E3 ligase TRAF6 regulates Akt ubiquitination and activation

5 July 2018

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Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination

5 July 2018

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5 July 2018

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Identification of novel neuroendocrine-specific tumour genes

5 July 2018

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

5 July 2018

1 reference

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Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion

5 July 2018

1 reference

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Signaling networks assembled by oncogenic EGFR and c-Met

5 July 2018

1 reference

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ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis.

5 July 2018

1 reference

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Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151226

Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells

5 July 2018

1 reference

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TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151226

Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151226

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients

5 July 2018

1 reference

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Distinct molecular mechanism for initiating TRAF6 signalling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151226

Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo.

5 July 2018

1 reference

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ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151226

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151226

Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151226

DCBLD2 gene variations correlate with nasal polyposis in Korean asthma patients

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25061874

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI73093

1 reference

release_nclfbztcwjfsjmu3rblvj6q3sy

31 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nclfbztcwjfsjmu3rblvj6q3sy

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

4151226

1 reference

31 July 2017

1 reference