The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis (Q24613186)

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2 February 2020

title

The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis (English)

1 reference

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2 February 2020

main subject

protein ubiquitination

1 reference

1

1 reference

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2 February 2020

15

Mien-Chie Hung

1 reference

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16

Keiichi I Nakayama

1 reference

2 February 2020

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10

Yiping Shao

1 reference

2 February 2020

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9

Leo G Flores

1 reference

2 February 2020

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Chien-Feng Li

2

1 reference

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2 February 2020

Wei-Lei Yang

3

1 reference

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2 February 2020

Yuan Gao

4

1 reference

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2 February 2020

Szu-Wei Lee

5

1 reference

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2 February 2020

Zizhen Feng

6

1 reference

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2 February 2020

Hsuan-Ying Huang

7

1 reference

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2 February 2020

Kelvin K C Tsai

8

1 reference

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2 February 2020

John D Hazle

11

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2 February 2020

Dihua Yu

12

1 reference

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2 February 2020

Wenyi Wei

13

1 reference

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2 February 2020

Dos Sarbassov

14

1 reference

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2 February 2020

Hui-Kuan Lin

17

1 reference

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2 February 2020

language of work or name

English

0 references

publication date

1 May 2012

1 reference

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2 February 2020

1 reference

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2 February 2020

volume

149

1 reference

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2 February 2020

issue

5

1 reference

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2 February 2020

page(s)

1098-1111

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Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development

2 February 2020

cites work

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7 April 2017

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Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice

7 April 2017

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The E3 ligase TRAF6 regulates Akt ubiquitination and activation

7 April 2017

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Direct activation of protein kinases by unanchored polyubiquitin chains

7 April 2017

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7 April 2017

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Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

7 April 2017

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Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

7 April 2017

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7 April 2017

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7 April 2017

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Ubiquitin ligases: cell-cycle control and cancer

7 April 2017

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7 April 2017

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7 April 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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On the InterAktion between hexokinase and the mitochondrion.

27 September 2017

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Skp2 regulates Myc protein stability and activity

27 September 2017

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PKB binding proteins. Getting in on the Akt.

27 September 2017

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Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1

27 September 2017

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Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

27 September 2017

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c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

27 September 2017

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Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.

27 September 2017

1 reference

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Skp2 overexpression is highly representative of intrinsic biological aggressiveness and independently associated with poor prognosis in primary localized myxofibrosarcomas.

30 May 2018

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

28 November 2018

1 reference

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Angiogenic acceleration of Neu induced mammary tumor progression and metastasis

28 November 2018

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The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

28 November 2018

1 reference

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Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

28 November 2018

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Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22632973

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

ErbB receptors and signaling pathways in cancer

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.02.065

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2012.02.065

2 references

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2 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22632973%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

22632973

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22632973%20AND%20SRC:MED&resulttype=core&format=json