The role of the LDL receptor in apolipoprotein B secretion (Q33939089)

30 July 2017

title

The role of the LDL receptor in apolipoprotein B secretion (English)

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30 July 2017

J Twisk

1

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30 July 2017

D L Gillian-Daniel

2

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30 July 2017

A Tebon

3

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30 July 2017

L Wang

4

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30 July 2017

P H Barrett

5

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30 July 2017

A D Attie

6

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30 July 2017

language of work or name

English

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publication date

1 February 2000

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Journal of Clinical Investigation

30 July 2017

published in

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30 July 2017

volume

105

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30 July 2017

issue

4

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30 July 2017

page(s)

521-532

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Protein measurement with the Folin phenol reagent

30 July 2017

cites work

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

5 July 2018

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Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding

5 July 2018

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Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100.

5 July 2018

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Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes

5 July 2018

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Intracellular degradation of newly synthesized apolipoprotein B.

5 July 2018

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3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and hepatic apolipoprotein B secretion

5 July 2018

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5 July 2018

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Apobec-1 and apolipoprotein B mRNA editing

5 July 2018

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Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

5 July 2018

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Role of cholesterol in regulating apolipoprotein B secretion by the liver

5 July 2018

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Apolipoprotein B mRNA editing in 12 different mammalian species: hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins

5 July 2018

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Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells.

5 July 2018

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Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

5 July 2018

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The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins

5 July 2018

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Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice

5 July 2018

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Cell surface down-modulation of CD4 after infection by HIV-1.

5 July 2018

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The beta-glucuronidase propeptide contains a serpin-related octamer necessary for complex formation with egasyn esterase and for retention within the endoplasmic reticulum

5 July 2018

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Degradation of apolipoprotein B in cultured rat hepatocytes occurs in a post-endoplasmic reticulum compartment

5 July 2018

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Effect of fatty acids on lipid and apoprotein secretion and association in hepatocyte cultures

5 July 2018

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Secretion of lipoproteins from the liver of normal and Watanabe heritable hyperlipidemic rabbits

5 July 2018

1 reference

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Impaired receptor-mediated catabolism of low density lipoprotein in the WHHL rabbit, an animal model of familial hypercholesterolemia

5 July 2018

1 reference

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Metabolism of native and of lactosylated human low density lipoprotein: evidence for two pathways for catabolism of exogenous proteins in rat hepatocytes

5 July 2018

1 reference

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

5 July 2018

1 reference

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The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia

5 July 2018

1 reference

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Intrahepatic assembly of very low density lipoproteins. Varied synthetic response of individual apolipoproteins to fasting.

5 July 2018

1 reference

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Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylase

5 July 2018

1 reference

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Suppression of apolipoprotein B production during treatment of cholesteryl ester storage disease with lovastatin. Implications for regulation of apolipoprotein B synthesis

5 July 2018

1 reference

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A receptor-mediated pathway for cholesterol homeostasis

5 July 2018

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Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atheroscleros

5 July 2018

1 reference

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Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits

5 July 2018

1 reference

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Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit

5 July 2018

1 reference

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Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

5 July 2018

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Studies on the expression of genes encoding apolipoproteins B100 and B48 and the low density lipoprotein receptor in nonhuman primates. Comparison of dietary fat and cholesterol.

5 July 2018

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Apolipoprotein B metabolism in homozygous familial hypercholesterolemia

5 July 2018

1 reference

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Isolation of RNA for dot hybridization by heparin-DNase I treatment of whole cell lysate.

5 July 2018

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

5 July 2018

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Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: implications for the pathophysiology of apoB production.

5 July 2018

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The unstirred water layer as a site of control of apolipoprotein B secretion

5 July 2018

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Developmental and age-related changes in apolipoprotein B mRNA editing in mice.

5 July 2018

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The discovery and development of HMG-CoA reductase inhibitors

5 July 2018

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Pause transfer: a topogenic sequence in apolipoprotein B mediates stopping and restarting of translocation

5 July 2018

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Metabolic studies in familial hypercholesterolemia. Evidence for a gene-dosage effect in vivo

5 July 2018

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Simultaneous measurement of apolipoprotein B turnover in very-low- and low-density lipoproteins in familial hypercholesterolaemia

5 July 2018

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Low density lipoprotein metabolism in a family of familial hypercholesterolemic patients

5 July 2018

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Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans

5 July 2018

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Subcellular localization of B apoprotein of plasma lipoproteins in rat liver

5 July 2018

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Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia

5 July 2018

1 reference

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Effects of atorvastatin on the intracellular stability and secretion of apolipoprotein B in HepG2 cells

29 October 2018

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Plasma lipoprotein distribution of apolipoprotein E in familial hypercholesterolemia

29 October 2018

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https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Human apolipoprotein B-100 heparin-binding sites

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12 December 2020

Intrahepatic assembly of very low density lipoproteins. Rate of transport out of the endoplasmic reticulum determines rate of secretion

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12 December 2020

Lovastatin therapy in receptor-negative homozygous familial hypercholesterolemia: Lack of effect on low-density lipoprotein concentrations or turnover

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Intrahepatic assembly of very low density lipoproteins: immunologic characterization of apolipoprotein B in lipoproteins and hepatic membrane fractions and its intracellular distribution

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12 December 2020

The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Oleic acid stimulation of apolipoprotein B secretion from HepG2 and Caco-2 cells occurs post-transcriptionally

1 reference

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12 December 2020

Pravastatin therapy in primary moderate hypercholesterolaemia: changes in metabolism of apolipoprotein B-containing lipoproteins

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https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

The signal for retention of the egasyn-glucuronidase complex within the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Transit and sorting of apolipoprotein B within the endoplasmic reticulum and Golgi compartments of isolated hepatocytes from normal and orotic acid-fed rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Characterization of recombinant human apoB-48-containing lipoproteins in rat hepatoma McA-RH7777 cells transfected with apoB-48 cDNA. Overexpression of apoB-48 decreases synthesis of endogenous apoB-100

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Regulation of apolipoprotein B secretion in hepatocytes from Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Comparative effects of HMG-CoA reductase inhibitors on apo B production in the casein-fed rabbit: atorvastatin versus lovastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Rapid genotyping of low density lipoprotein receptor knockout mice using a polymerase chain reaction technique

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Glucose 6-Phosphate Produced by Glucokinase, but Not Hexokinase I, Promotes the Activation of Hepatic Glycogen Synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Purification of the apolipoprotein B-67-containing low density lipoprotein particle and its affinity for the low density lipoprotein receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

RAP, a novel type of ER chaperone

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https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

The NH2-terminal region of apolipoprotein B is sufficient for lipoprotein association with glycosaminoglycans

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Presecretory degradation of apolipoprotein [a] is mediated by the proteasome pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

A two-site model for ApoB degradation in HepG2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Co-translational degradation of apolipoprotein B100 by the proteasome is prevented by microsomal triglyceride transfer protein. Synchronized translation studies on HepG2 cells treated with an inhibitor of microsomal triglyceride transfer protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Lovastatin decreases de novo cholesterol synthesis and LDL Apo B-100 production rates in combined-hyperlipidemic males

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low density lipoprotein receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Mevinolin and cholestyramine inhibit the direct synthesis of low density lipoprotein apolipoprotein B in miniature pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Influence of mevinolin on metabolism of low density lipoproteins in primary moderate hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

The role of apolipoprotein processing in receptor recognition of VLDL

1 reference

https://pubmed.ncbi.nlm.nih.gov/10683382

12 December 2020

Identifiers

DOI

10.1172/JCI8623

1 reference

30 July 2017

1 reference

30 July 2017

1 reference