Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylase (Q40919334)

24 September 2017

Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylase (English)

1 reference

24 September 2017

H M Princen

1

1 reference

24 September 2017

C M Huijsmans

2

1 reference

24 September 2017

F Kuipers

3

1 reference

24 September 2017

R J Vonk

4

1 reference

24 September 2017

H J Kempen

5

1 reference

24 September 2017

language of work or name

English

0 references

publication date

1 October 1986

1 reference

Journal of Clinical Investigation

24 September 2017

1 reference

24 September 2017

78

1 reference

24 September 2017

4

1 reference

24 September 2017

1064-1071

1 reference

Protein measurement with the Folin phenol reagent

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Transport of sodium, chloride, and taurocholate by cultured rat hepatocytes

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Inhibition by ketoconazole of mitogen-induced DNA synthesis and cholesterol biosynthesis in lymphocytes

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Disposition of ketoconazole, an oral antifungal, in humans

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Gynecomastia with ketoconazole

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Biochemical targets for antifungal azole derivatives: hypothesis on the mode of action.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Uptake of Taurocholic Acid into Isolated Rat-Liver Cells

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

An in vivo evaluation of the quantitative significance of several potential pathways to cholic and chenodeoxycholic acids from cholesterol in man.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

The influence of glucocorticoid on the fibrinogen messenger RNA content of rat liver in vivo and in hepatocyte suspension culture

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Ketoconazole Blocks Testosterone Synthesis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Ketoconazole Blocks Adrenal Steroid Synthesis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Trypan blue dye uptake and lactate dehydrogenase in adult rat hepatocytes—Freshly isolated cells, cell suspensions, and primary monolayer cultures

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Changes in in vivo metabolism of bile acids in rat after treatment with phenobarbital.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Long-term cell culture of adult rat liver epithelial cells.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Characterisation of rat hepatocyte monolayers for investigation of the metabolism of bile salts

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Enterohepatic circulation in the rat.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Effects of long-term ketoconazole therapy on serum lipid levels

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Bile secretion and bile composition in the freely moving, unanaesthetized rat with a permanent biliary drainage: influence of food intake on bile flow

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Regulation of biliary cholesterol output in the rat: dissociation from the rate of hepatic cholesterol synthesis, the size of the hepatic cholesteryl ester pool, and the hepatic uptake of chylomicron cholesterol

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Preferential utilization of newly synthesized cholesterol as substrate for bile acid biosynthesis. An in vivo study using 18O2-inhalation technique

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Micellar theory of biliary cholesterol excretion

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423762

Cholesterol 7 alpha-hydroxylase

19 August 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

The contribution of newly synthesized cholesterol to biliary cholesterol in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Role of endogenous and exogenous cholesterol in liver as the precursor for bile acids in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Rat liver cholesterol 7 alpha-hydroxylase. Modulation of enzyme activity by changes in phosphorylation state

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Hydroxylations in biosynthesis of bile acids. Isolation of subfractions with different substrate specificity from cytochrome P-450LM4

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Bile acids and lipids in isolated rat hepatocytes: content, synthesis, and release, as affected by cholestyramine treatment of the donor rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Bile acid secretion by cultured rat hepatocytes. Regulation by cholesterol availability

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Effects of drugs and sterols on cholesterol 7 alpha-hydroxylase activity in rat liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Bile acids and lipids in isolated rat hepatocytes. II. Source of cholesterol used for bile acid formation, estimated by incorporation of tritium from tritiated water, and by the effect of ML-236B

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Bile acids and lipid metabolism. IV. Influence of bile acids on biliary and liver organelle phospholipids and cholesterol

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Biochemical site of regulation of bile acid biosynthesis in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Mechanism of cholestasis. 5. Bile acids in normal rat livers and in those after bile duct ligation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Site of Action of Low Dose Ketoconazole on Androgen Biosynthesis in Men*

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Effect of ML-236B (compactin) on biliary excretion of bile salts and lipids, and on bile flow, in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Ketoconazole: a potent inhibitor of cytochrome P-450-dependent drug metabolism in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Ketoconazole and cholesterol synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Suitability of primary monolayer cultures of adult rat hepatocytes for studies of cholesterol and bile acid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Effect of ketoconazole on hepatic oxidative drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

The effect of ketoconazole on hepatic oxidative drug metabolism in the rat in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Inhibition of plasminogen activators by conditioned medium of human hepatocytes and hepatoma cell line Hep G2

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Bile acids. I. Two new acids from rat bile

1 reference

https://pubmed.ncbi.nlm.nih.gov/3760182

12 December 2020

Identifiers

DOI

10.1172/JCI112662

1 reference

24 September 2017

1 reference

24 September 2017

PubMed publication ID

3760182

1 reference