The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice (Q33895709)

29 July 2017

title

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice (English)

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Leticia Quintanilla-Martínez de Fend

29 July 2017

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12

object named as

Leticia Quintanilla-Martinez

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Susanne Schnittger

9

object named as

Susanne Schnittger

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29 July 2017

11

Wolfgang Hiddemann

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29 July 2017

Michaela Feuring-Buske

14

object named as

Michaela Feuring-Buske

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29 July 2017

3

Monica Cusan

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29 July 2017

Christina Schessl

1

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29 July 2017

Vijay P S Rawat

2

1 reference

29 July 2017

Aniruddha Deshpande

4

1 reference

29 July 2017

Tobias M Kohl

5

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29 July 2017

Patricia M Rosten

6

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29 July 2017

Karsten Spiekermann

7

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29 July 2017

R Keith Humphries

8

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29 July 2017

Wolfgang Kern

10

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29 July 2017

Stefan K Bohlander

13

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29 July 2017

Christian Buske

15

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29 July 2017

language of work or name

English

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publication date

14 July 2005

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Journal of Clinical Investigation

29 July 2017

published in

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29 July 2017

volume

115

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29 July 2017

issue

8

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29 July 2017

page(s)

2159-2168

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Internal tandem duplications of the FLT3 gene are present in leukemia stem cells

29 July 2017

cites work

1 reference

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Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

5 July 2018

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AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.

5 July 2018

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PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia

5 July 2018

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Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

5 July 2018

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High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells

5 July 2018

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5 July 2018

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5 July 2018

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Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia

5 July 2018

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FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy

5 July 2018

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The role of FLT3 in haematopoietic malignancies

5 July 2018

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An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice

5 July 2018

1 reference

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Molecular genetics of human leukemias: new insights into therapy

5 July 2018

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AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

5 July 2018

1 reference

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5 July 2018

Focus on acute leukemias

1 reference

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Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

5 July 2018

1 reference

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

5 July 2018

1 reference

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Bethesda proposals for classification of lymphoid neoplasms in mice

5 July 2018

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Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

5 July 2018

1 reference

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PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

5 July 2018

1 reference

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FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

5 July 2018

1 reference

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The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

5 July 2018

1 reference

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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

5 July 2018

1 reference

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Stem cells, cancer, and cancer stem cells

5 July 2018

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AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.

5 July 2018

1 reference

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AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

5 July 2018

1 reference

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AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

5 July 2018

1 reference

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AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

5 July 2018

1 reference

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The role of chromosome translocations in leukemogenesis.

5 July 2018

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World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997.

5 July 2018

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The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

Oncogenic transcription factors in the human acute leukemias

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

Functional domains of the t(8;21) fusion protein, AML-1/ETO.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

Proposals for the Classification of the Acute Leukaemias French-American-British (FAB) Co-operative Group

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

Determination of relapse risk based on assessment of minimal residual disease during complete remission by multiparameter flow cytometry in unselected patients with acute myeloid leukemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

FLT3 mutations in childhood acute lymphoblastic leukemia

29 October 2018

1 reference

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New score predicting for prognosis in PML-RARA+, AML1-ETO+, or CBFBMYH11+ acute myeloid leukemia based on quantification of fusion transcripts.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

The protein tyrosine kinase inhibitor SU5614 inhibits VEGF-induced endothelial cell sprouting and induces growth arrest and apoptosis by inhibition of c-kit in AML cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment.

29 October 2018

1 reference

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Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174917

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

29 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025155

12 December 2020

Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025155

12 December 2020

Partial tandem duplications of the MLL gene are detectable in peripheral blood and bone marrow of nearly all healthy donors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025155

12 December 2020

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16025155

12 December 2020

Identifiers

DOI

10.1172/JCI24225

1 reference

29 July 2017

1 reference

29 July 2017

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