Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway (Q33858419)

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English	Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway	scientific article

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25 March 2020

Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway (English)

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25 March 2020

Motohiro Nishida

6

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25 March 2020

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Sarawuth Phosri

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25 March 2020

Ajaree Arieyawong

2

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25 March 2020

Kwanchai Bunrukchai

3

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25 March 2020

Warisara Parichatikanond

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25 March 2020

Akiyuki Nishimura

5

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25 March 2020

Supachoke Mangmool

7

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25 March 2020

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30 June 2017

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25 March 2020

Frontiers in Pharmacology

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25 March 2020

8

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25 March 2020

428

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25 March 2020

Targeting Adenosine Receptors for the Treatment of Cardiac Fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

EPAC expression and function in cardiac fibroblasts and myofibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

cAMP and Epac in the regulation of tissue fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Pulmonary fibroblasts, an emerging target for anti-obstructive drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Endocardial endothelial cells stimulate proliferation and collagen synthesis of cardiac fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Cardiac fibroblasts: friend or foe?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

The cardiac fibroblast: therapeutic target in myocardial remodeling and failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

A3 adenosine receptor activation inhibits cell proliferation via phosphatidylinositol 3-kinase/Akt-dependent inhibition of the extracellular signal-regulated kinase 1/2 phosphorylation in A375 human melanoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Functional effects of enhancing or silencing adenosine A2b receptors in cardiac fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Modulation of cardiac remodeling by adenosine: in vitro and in vivo effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Signalling from adenosine receptors to mitogen-activated protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Adenosine receptors: G protein-mediated signalling and the role of accessory proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Structure and function of adenosine receptors and their genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Adenosine induces cyclic-AMP formation and inhibits endothelin-1 production/secretion in guinea-pig tracheal epithelial cells through A(2B) adenosine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Adenosine inhibits collagen and protein synthesis in cardiac fibroblasts: role of A2B receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

Regulation of endothelin-1 production in cultured rat mesangial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

28 July 2018

ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy.

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

Differential expression of adenosine receptors in human endothelial cells: role of A2B receptors in angiogenic factor regulation

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

The pathogenesis of cardiac fibrosis.

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

Role of endogenous endothelin in chronic heart failure: effect of long-term treatment with an endothelin antagonist on survival, hemodynamics, and cardiac remodeling

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

Cardiac fibroblasts: at the heart of myocardial remodeling

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

Signaling pathways involving adenosine A2A and A2B receptors in wound healing and fibrosis.

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

Homology modelling of the human adenosine A2B receptor based on X-ray structures of bovine rhodopsin, the beta2-adrenergic receptor and the human adenosine A2A receptor

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

Myofibroblasts and mechano-regulation of connective tissue remodelling

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K.

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

Blockade of A2B adenosine receptor reduces left ventricular dysfunction and ventricular arrhythmias 1 week after myocardial infarction in the rat model

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2017.00428

21 January 2018

A(2b) receptors mediate the antimitogenic effects of adenosine in cardiac fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5492828

29 October 2018

Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning

1 reference

https://pubmed.ncbi.nlm.nih.gov/28713274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of renin-angiotensin and endothelin systems in development of diastolic heart failure in hypertensive hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/28713274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic AMP-dependent, protein kinase A-independent activation of extracellular signal-regulated kinase 1/2 following adenosine receptor stimulation in human umbilical vein endothelial cells: role of exchange protein activated by cAMP 1 (Epac1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/28713274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/28713274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exogenous and endogenous adenosine inhibits fetal calf serum-induced growth of rat cardiac fibroblasts: role of A2B receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/28713274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term stimulation of adenosine A2b receptors begun after myocardial infarction prevents cardiac remodeling in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/28713274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FPHAR.2017.00428

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28713274%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

PMC publication ID

1 reference

Europe PubMed Central

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25 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28713274%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

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