Reaching for high-hanging fruit in drug discovery at protein-protein interfaces (Q29547258)

Europe PubMed Central

title

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces (English)

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23 April 2017

1 reference

Wells JA

1

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23 April 2017

McClendon CL

series ordinal

2

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23 April 2017

language of work or name

1 reference

23 April 2017

publication date

13 December 2007

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23 April 2017

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23 April 2017

volume

450

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23 April 2017

issue

7172

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23 April 2017

page(s)

1001-9

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Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

23 April 2017

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Protein-protein interactions as targets for small molecule drug discovery

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7 January 2021

Protein-protein interactions and cancer: small molecules going in for the kill

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7 January 2021

Binding of small molecules to an adaptive protein-protein interface

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7 January 2021

Discovery of a potent small molecule IL-2 inhibitor through fragment assembly

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7 January 2021

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions

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7 January 2021

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Optimization of binding electrostatics: charge complementarity in the barnase-barstar protein complex.

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Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody

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The Bcl-2 protein family: arbiters of cell survival

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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7 January 2021

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7 January 2021

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7 January 2021

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

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7 January 2021

NMR structure of a complex between MDM2 and a small molecule inhibitor

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7 January 2021

Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex

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7 January 2021

Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction

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7 January 2021

Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor

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7 January 2021

Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: a combined medicinal chemistry, NMR and computational chemistry approach

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7 January 2021

The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2.

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7 January 2021

The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography

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7 January 2021

Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design

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7 January 2021

Druggability indices for protein targets derived from NMR-based screening data

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α

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7 January 2021

Small-molecule inhibition of TNF-alpha

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Relating protein pharmacology by ligand chemistry

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7 January 2021

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7 January 2021

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7 January 2021

Solution structure and dynamics of the complex between cytochrome c and cytochrome c peroxidase determined by paramagnetic NMR

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7 January 2021

Visualization of transient encounter complexes in protein-protein association.

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7 January 2021

Drug-like properties and the causes of poor solubility and poor permeability

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7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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7 January 2021

Fragment-based lead discovery: a chemical update

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7 January 2021

Refined structure of alpha beta-tubulin at 3.5 A resolution

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7 January 2021

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

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7 January 2021

Crystal structures of cyclophilin and its partners

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7 January 2021

The structure of a yeast hexokinase monomer and its complexes with substrates at 2.7-A resolution

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7 January 2021

Space-Filling Models of Kinase Clefts and Conformation Changes

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7 January 2021

Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.

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7 January 2021

Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screening

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7 January 2021

Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes

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7 January 2021

An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

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7 January 2021

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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7 January 2021

Potent inhibition of the CD4-dependent T cell response by J2, a novel nonpeptide organic ligand of CD4 D1.

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7 January 2021

Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.

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7 January 2021

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

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7 January 2021

Discovery of selective small-molecule CD80 inhibitors.

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7 January 2021

Unraveling hot spots in binding interfaces: progress and challenges

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7 January 2021

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Identifiers

2 references

23 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1038231590

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18075579

PubMed publication ID

2 references

23 April 2017

Consolidated OpenCitations Corpus – April 2017