Initiation and perpetuation of NLRP3 inflammasome activation and assembly (Q28082177)

title

Initiation and perpetuation of NLRP3 inflammasome activation and assembly (English)

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879282%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Fayyaz S Sutterwala

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879282%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

language of work or name

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May 2015

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published in

Immunological Reviews

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879282%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

265

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879282%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

1

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879282%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

35-52

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879282%20AND%20SRC:MED&resulttype=core&format=json

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

9 June 2020

cites work

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The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation

20 March 2017

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TRPM2 links oxidative stress to NLRP3 inflammasome activation

20 March 2017

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MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

20 March 2017

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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

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Crystal Structure of NALP3 Protein Pyrin Domain (PYD) and Its Implications in Inflammasome Assembly

20 March 2017

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20 March 2017

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20 March 2017

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IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

20 March 2017

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Making heads or tails of phospholipids in mitochondria

20 March 2017

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Inflammasomes: too big to miss

20 March 2017

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

20 March 2017

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

20 March 2017

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The Nalp3 inflammasome is essential for the development of silicosis

20 March 2017

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Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

20 March 2017

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The NLR gene family: a standard nomenclature

20 March 2017

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The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

20 March 2017

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Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

20 March 2017

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Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

20 March 2017

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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

20 March 2017

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The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition

20 March 2017

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De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

20 March 2017

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

20 March 2017

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

20 March 2017

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Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

20 March 2017

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The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

20 March 2017

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A role for mitochondria in NLRP3 inflammasome activation

20 March 2017

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Gout-associated uric acid crystals activate the NALP3 inflammasome

20 March 2017

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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

20 March 2017

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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

20 March 2017

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Mitochondrial calcium and the permeability transition in cell death

20 March 2017

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Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain

20 March 2017

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Cryopyrin activates the inflammasome in response to toxins and ATP

20 March 2017

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Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

20 March 2017

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Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

20 March 2017

1 reference

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Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

20 March 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Phosphorylation of NLRC4 is critical for inflammasome activation

20 March 2017

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Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

20 March 2017

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ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages

20 March 2017

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The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

20 March 2017

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

20 March 2017

1 reference

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

7 April 2017

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NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

7 April 2017

1 reference

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Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

7 April 2017

1 reference

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

7 April 2017

1 reference

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Mitochondria and cell death: outer membrane permeabilization and beyond

7 April 2017

1 reference

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

7 April 2017

1 reference

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

7 April 2017

1 reference

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

7 April 2017

1 reference

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

7 April 2017

1 reference

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

7 April 2017

1 reference

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

7 April 2017

1 reference

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BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Keeping the immune system in check: a role for mitophagy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Structural mechanisms in NLR inflammasome signaling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

The growing landscape of lysine acetylation links metabolism and cell signalling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Mechanism of NLRP3 inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Rift Valley fever virus infection induces activation of the NLRP3 inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

How metabolism generates signals during innate immunity and inflammation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Metabolic pathways in immune cell activation and quiescence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Pannexin-1 influences peritoneal cavity cell population but is not involved in NLRP3 inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cell volume regulation modulates NLRP3 inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Mitochondria as sensors and regulators of calcium signalling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Sensing and reacting to microbes through the inflammasomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Caspase-1-induced pyroptotic cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Sensing damage by the NLRP3 inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cutting edge: NLRC5-dependent activation of the inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Oxidative stress caused by mitochondrial calcium overload

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Malarial hemozoin is a Nalp3 inflammasome activating danger signal

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

CA-074Me protection against anthrax lethal toxin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Fungal zymosan and mannan activate the cryopyrin inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Apoptosome: a platform for the activation of initiator caspases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Calmodulin kinase II regulates the maturation and antigen presentation of human dendritic cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cellular localization of NLRP3 inflammasome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

The NLRP12 inflammasome recognizes Yersinia pestis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Evolutionary diversity of the mitochondrial calcium uniporter

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections.

2 June 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Mycobacterium tuberculosis phagosomes exhibit altered calmodulin-dependent signal transduction: contribution to inhibition of phagosome-lysosome fusion and intracellular survival in human macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Human NLRP3 inflammasome activation is Nox1-4 independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1β production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

The cardiolipin-binding domain of Bid affects mitochondrial respiration and enhances cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

The interaction between tBid and cardiolipin or monolysocardiolipin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Cardiolipin deficiency releases cytochrome c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Modeling AAA+ ring complexes from monomeric structures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12286

Early changes in intramitochondrial cardiolipin distribution during apoptosis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4400874

Mitochondrial contact sites. Lipid composition and dynamics

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25879282

12 December 2020

Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25879282

12 December 2020

Cardiolipin provides specificity for targeting of tBid to mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/25879282

12 December 2020

Human monocyte interleukin-1beta posttranslational processing. Evidence of a volume-regulated response

1 reference

https://pubmed.ncbi.nlm.nih.gov/25879282

12 December 2020

Cutting edge: nitric oxide inhibits the NLRP3 inflammasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/25879282

12 December 2020

Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/25879282

12 December 2020

The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25879282

12 December 2020

Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/25879282

12 December 2020

Identifiers

DOI

10.1111/IMR.12286

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879282%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879282%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

25879282

2 references