Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors (Q36503546)

14 August 2017

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors (English)

1 reference

G protein-coupled receptor

14 August 2017

0 references

1 reference

1

Manuela Rossol

0 references

Sanela Smajilovic

11

object named as

Sanela Smajilovic

0 references

Dagmar Quandt

4

object named as

Dagmar Quandt

0 references

Hans Bräuner-Osborne

12

object named as

Hans Bräuner-Osborne

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author name string

Manuela Rossol

1

1 reference

14 August 2017

Matthias Pierer

2

1 reference

14 August 2017

Nora Raulien

3

1 reference

14 August 2017

Dagmar Quandt

4

1 reference

14 August 2017

Undine Meusch

5

1 reference

14 August 2017

Kathrin Rothe

6

1 reference

14 August 2017

Kristin Schubert

7

1 reference

14 August 2017

Torsten Schöneberg

8

1 reference

14 August 2017

Michael Schaefer

9

1 reference

14 August 2017

Ute Krügel

10

1 reference

14 August 2017

Sanela Smajilovic

11

1 reference

14 August 2017

Hans Bräuner-Osborne

12

1 reference

14 August 2017

Christoph Baerwald

13

1 reference

14 August 2017

Ulf Wagner

14

1 reference

14 August 2017

language of work or name

English

0 references

publication date

1 January 2012

1 reference

14 August 2017

Nature Communications

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14 August 2017

3

1 reference

14 August 2017

1329

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The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Sterile inflammation: sensing and reacting to damage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

IL-1 pathways in inflammation and human diseases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Mechanisms of multimodal sensing by extracellular Ca(2+)-sensing receptors: a domain-based survey of requirements for binding and signalling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

IL-18 in autoimmunity: review

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Identification of a novel extracellular cation-sensing G-protein-coupled receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Carrageenan-induced paw edema in the rat and mouse

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Altered cytokine production in mice lacking P2X(7) receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Intercellular communication mediated by the extracellular calcium-sensing receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Ionized calcium in body fluids

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Evidence for agonist-induced export of intracellular Ca2+ in epithelial cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Calcification of myocardial necrosis is common in mice.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535422

Use of ultrafiltration probes in sheep to collect interstitial fluid for measurement of calcium and magnesium

4 December 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/23271661

12 December 2020

Correlation of cell necrosis and tissue calcification with ischemia/reperfusion injury after liver transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23271661

12 December 2020

Quantitative analysis of sodium, potassium and calcium in gingival fluid from gingiva in varying degrees of inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23271661

12 December 2020

Pulsatile Ca2+ extrusion from single pancreatic acinar cells during receptor-activated cytosolic Ca2+ spiking

1 reference

https://pubmed.ncbi.nlm.nih.gov/23271661

12 December 2020

Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/23271661

12 December 2020

Identifiers

DOI

10.1038/NCOMMS2339

1 reference

14 August 2017

0 references

1 reference

14 August 2017

PubMed publication ID

23271661

1 reference