Active and passive immunotherapy for neurodegenerative disorders (Q24657879)

Annual Review of Neuroscience

Europe PubMed Central

title

Active and passive immunotherapy for neurodegenerative disorders (English)

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David M Holtzman

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author name string

David L Brody

series ordinal

1

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language of work or name

English

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publication date

2008

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published in

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volume

31

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issue

1

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page(s)

175-93

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cites work

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Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

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Reversible memory loss in a mouse transgenic model of Alzheimer's disease

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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

7 April 2017

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Developments of a water-maze procedure for studying spatial learning in the rat

7 April 2017

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Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees

28 September 2017

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Potential of active and passive immunizations for the prevention and therapy of transmissible spongiform encephalopathies

28 September 2017

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Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells.

28 September 2017

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Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis

28 September 2017

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Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults

28 September 2017

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28 September 2017

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Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis

28 September 2017

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Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now.

28 September 2017

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Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody

28 September 2017

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Treatment and prevention of primary intracerebral hemorrhage

28 September 2017

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The F(ab)'2 fragment of an Abeta-specific monoclonal antibody reduces Abeta deposits in the brain

28 September 2017

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Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

28 September 2017

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Mucosal vaccination delays or prevents prion infection via an oral route.

28 September 2017

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Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

28 September 2017

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Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

28 September 2017

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Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

28 September 2017

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28 September 2017

Head injury and dementia

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Deciphering the molecular basis of memory failure in Alzheimer's disease

28 September 2017

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Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease

28 September 2017

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Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease

28 September 2017

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Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

28 September 2017

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Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

28 September 2017

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

28 September 2017

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A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

28 September 2017

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Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides

28 September 2017

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Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein

28 September 2017

1 reference

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Disaggregation of Alzheimer beta-amyloid by site-directed mAb.

28 September 2017

1 reference

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

28 September 2017

1 reference

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Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide

28 September 2017

1 reference

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Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice.

28 September 2017

1 reference

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Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies

30 May 2018

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

30 May 2018

1 reference

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Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease

30 May 2018

1 reference

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Frequency of stages of Alzheimer-related lesions in different age categories

30 May 2018

1 reference

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Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Evaluation of the safety and immunogenicity of synthetic A 42 (AN1792) in patients with AD

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Clinical manifestations of cerebral amyloid angiopathy-related inflammation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Cerebral hemorrhage after passive anti-Abeta immunotherapy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Human antibodies against amyloid beta peptide: a potential treatment for Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561172

Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/18352830

12 December 2020

Monoclonal antibodies inhibit prion replication and delay the development of prion disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18352830

12 December 2020

Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/18352830

12 December 2020

Herceptin: HERalding a new era in breast cancer care but at what cost?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18352830

12 December 2020

10.1146/ANNUREV.NEURO.31.060407.125529

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

18352830

1 reference