Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1) (Q24307730)

Mitogen-activated protein kinase 12

Europe PubMed Central

title

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1) (English)

0 references

main subject

biochemistry

0 references

1 reference

Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

1 reference

HtrA serine peptidase 2

1 reference

PTEN induced kinase 1

1 reference

Parkin RBR E3 ubiquitin protein ligase

1 reference

AKT serine/threonine kinase 1

1 reference

TNF receptor associated factor 2

1 reference

TNF receptor associated protein 1

1 reference

negative regulation of neuron death

1 reference

Heung-Chin Cheng

6

0 references

Terrence D. Mulhern

object named as

Terrence D Mulhern

4

0 references

author name string

Ryan D Mills

1

0 references

Chou Hung Sim

2

0 references

Su San Mok

3

0 references

Janetta G Culvenor

Journal of Neurochemistry

5

0 references

language of work or name

English

0 references

publication date

April 2008

0 references

published in

0 references

volume

105

0 references

issue

1

0 references

page(s)

18-33

0 references

cites work

Oxidative stress in neurodegeneration: cause or consequence?

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

20 April 2017

Pathways to Parkinsonism

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

The mitochondrial death squad: hardened killers or innocent bystanders?

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

PINK1 protein in normal human brain and Parkinson's disease

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

The structure of Sky1p reveals a novel mechanism for constitutive activity

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Synthesis and function of 3-phosphorylated inositol lipids

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05249.X

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Computational method to predict mitochondrially imported proteins and their targeting sequences

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

The PINK1/Parkin pathway regulates mitochondrial morphology

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Expanding insights of mitochondrial dysfunction in Parkinson's disease.

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Adult neuron survival strategies--slamming on the brakes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Phenotypic characterisation of autosomal recessive PARK6-linked parkinsonism in three unrelated Italian families

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Neurodegeneration: how does parkin prevent Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Functions of outer membrane receptors in mitochondrial protein import

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Nosology of Parkinson's disease: looking for the way out of a quagmire

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Parkinson's disease: the genetics of a heterogeneous disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Novel PINK1 mutations in early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

PINK1 (PARK6) associated Parkinson disease in Ireland

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

A tale of two mitochondrial channels, MAC and PTP, in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Progress in the clinical and molecular genetics of familial parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

The genetics of Parkinson disease: Implications for neurological care

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Deciphering the role of heterozygous mutations in genes associated with parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Proline residues of transmembrane domains determine the sorting of inner membrane proteins in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Parkin: a multifaceted ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Neurodegenerative disease: pink, parkin and the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Inhibition of apoptotic signaling cascades causes loss of trophic factor dependence during neuronal maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

NF-kappaB signaling: flipping the switch with polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

21 January 2018

Parkin blushed by PINK1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Pathogenic mutations in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

PINK1 mutations are associated with sporadic early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Apoptosis in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Cleavage-site motifs in mitochondrial targeting peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

A heterozygous effect for PINK1 mutations in Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Heterozygous PINK1 mutations: a susceptibility factor for Parkinson disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Phenotypic spectrum of PINK1-associated parkinsonism in 15 mutation carriers from 1 family

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

The mitochondrial machinery for import of precursor proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Protein import into mitochondria: two systems acting in tandem?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Protein insertion into the inner membrane of mitochondria

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Analysis of PINK1 in Asian patients with familial parkinsonism

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Programmed cell death and new discoveries in the genetics of parkinsonism.

1 reference