Roles of CHOP/GADD153 in endoplasmic reticulum stress (Q24302185)

Heat shock protein family A (Hsp70) member 5

Europe PubMed Central

title

Roles of CHOP/GADD153 in endoplasmic reticulum stress (English)

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main subject

endoplasmic reticulum

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Death associated protein kinase 3

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Activating transcription factor 3

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CCAAT enhancer binding protein alpha

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Activating transcription factor 4

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DNA damage inducible transcript 3

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CCAAT enhancer binding protein beta

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TNF receptor associated factor 2

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intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

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Cell Death & Differentiation

author name string

S Oyadomari

series ordinal

1

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M Mori

series ordinal

2

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language of work or name

English

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publication date

April 2004

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published in

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volume

11

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issue

4

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page(s)

381-9

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cites work

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Tripartite management of unfolded proteins in the endoplasmic reticulum

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Translational control in the endoplasmic reticulum stress response

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Orchestrating the unfolded protein response in health and disease

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Transcriptional and translational control in the Mammalian unfolded protein response

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The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

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7 January 2021

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

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The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein

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7 January 2021

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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7 January 2021

ER quality control: the cytoplasmic connection

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7 January 2021

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

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A time-dependent phase shift in the mammalian unfolded protein response

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7 January 2021

Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention

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7 January 2021

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

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7 January 2021

Organelle-specific initiation of cell death pathways

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7 January 2021

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

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7 January 2021

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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7 January 2021

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

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7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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7 January 2021

Human caspase 12 has acquired deleterious mutations

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

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7 January 2021

Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element

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7 January 2021

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms

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7 January 2021

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

DNA damage-inducible transcripts in mammalian cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

BiP binding keeps ATF6 at bay.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

CHOP gene expression in response to endoplasmic-reticular stress requires NFY interaction with different domains of a conserved DNA-binding element

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex

1 reference

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7 January 2021

Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Regulated translation initiation controls stress-induced gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

gadd153/Chop10, a potential target gene of the transcriptional repressor ATF3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Normal Fibroblasts Induce the C/EBPβ and ATF-4 bZIP Transcription Factors in Response to Anoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Amino Acid Limitation Induces Expression ofCHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

CHOP/GADD153 gene expression response to cellular stresses inhibited by prior exposure to ultraviolet light wavelength band C (UVC). Inhibitory sequence mediating the UVC response localized to exon 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Identification of novel stress-induced genes downstream of chop

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

ZIP kinase, a novel serine/threonine kinase which mediates apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Plasma cell differentiation requires the transcription factor XBP-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Perk is essential for translational regulation and cell survival during the unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

beta-Cell death during progression to diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

The unfolded protein response in nutrient sensing and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Endoplasmic reticulum stress and the development of diabetes: a review

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Endoplasmic reticulum stress and diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Autopsy findings in the Wolcott-Rallison syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Nitric oxide synthase in cardiac sarcoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Protein aggregation after focal brain ischemia and reperfusion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Microarray analysis of hippocampal gene expression in global cerebral ischemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Effect of nitric oxide on endoplasmic reticulum calcium homeostasis, protein synthesis and energy metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Neuroprotective nitric oxide synthase inhibitor reduces intracellular calcium accumulation following transient global ischemia in the gerbil

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401373

7 January 2021