Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis (Q24298202)

Egl-9 family hypoxia inducible factor 2

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Prolyl 4-hydroxylase, transmembrane

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Egl-9 family hypoxia inducible factor 1

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2-oxoglutarate-dependent dioxygenase activity

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Prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

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11

Johanna Myllyharju

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author name string

Anu Laitala

1

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Ellinoora Aro

2

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Gail Walkinshaw

3

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Joni M Mäki

4

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Maarit Rossi

5

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Minna Heikkilä

6

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Eeva-Riitta Savolainen

7

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Michael Arend

8

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Kari I Kivirikko

9

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Peppi Koivunen

Non-hypoxic stabilization of hypoxia-inducible factor alpha (HIF-alpha): relevance in neural progenitor/stem cells

10

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language of work or name

English

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publication date

18 October 2012

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published in

Blood

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volume

120

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issue

16

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page(s)

3336-44

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cites work

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7 January 2021

Short-term effects of pharmacologic HIF stabilization on vasoactive and cytotrophic factors in developing mouse brain.

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7 January 2021

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase

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7 January 2021

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

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The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.

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7 January 2021

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

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7 January 2021

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

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7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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7 January 2021

Hypoxia-inducible factor-2alpha-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization

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Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

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7 January 2021

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

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7 January 2021

Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.

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7 January 2021

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

1 reference

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7 January 2021

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

1 reference

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7 January 2021

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

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7 January 2021

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

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7 January 2021

Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury

1 reference

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7 January 2021

Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function

1 reference

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7 January 2021

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

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7 January 2021

An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha

1 reference

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7 January 2021

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

1 reference

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7 January 2021

Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney

1 reference

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7 January 2021

Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway

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7 January 2021

Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor

1 reference

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7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

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7 January 2021

Reactivation of hepatic EPO synthesis in mice after PHD loss

1 reference

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7 January 2021

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

1 reference

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7 January 2021

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

1 reference

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7 January 2021

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

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7 January 2021

Hypoxia. 5. Hypoxia and hematopoiesis

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7 January 2021

Hypoxic regulation of erythropoiesis and iron metabolism

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7 January 2021

Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia

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7 January 2021

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system

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7 January 2021

HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

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7 January 2021

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

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7 January 2021

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

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7 January 2021

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

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7 January 2021

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

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7 January 2021

HIF prolyl hydroxylase inhibitors for anemia

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7 January 2021

Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2012-07-441824

7 January 2021

HIF prolyl 4-hydroxylases and their potential as drug targets

1 reference

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7 January 2021

Isolated erythrocytosis: study of 67 patients and identification of three novel germ-line mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene

1 reference

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7 January 2021

Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2012-07-441824

7 January 2021

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

1 reference

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7 January 2021