Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis (Q37506973)

20 August 2017

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title

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis (English)

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20 August 2017

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1

Gregg L Semenza

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20 August 2017

language of work or name

English

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publication date

3 June 2009

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20 August 2017

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20 August 2017

volume

114

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20 August 2017

issue

10

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20 August 2017

page(s)

2015-2019

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

20 August 2017

cites work

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A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

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HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

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Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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12 October 2022

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Identification of a hypoxia response element in the transferrin receptor gene

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12 October 2022

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Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

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12 October 2022

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Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1.

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12 October 2022

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?

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12 October 2022

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Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury

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12 October 2022

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Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

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12 October 2022

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Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

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12 October 2022

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Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

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12 October 2022

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Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

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12 October 2022

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Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases

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12 October 2022

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Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene

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12 October 2022

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A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

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12 October 2022

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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

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12 October 2022

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A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove

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12 October 2022

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Biology of hypoxia-inducible factor-2alpha in development and disease

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12 October 2022

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Control of erythropoietin gene expression and its use in medicine

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Regulation of oxygen homeostasis by hypoxia-inducible factor 1.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis

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12 October 2022

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

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12 October 2022

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Vascular complications in Chuvash polycythemia

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

1 reference

12 October 2022

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Genetic mechanisms underlying regulation of hemoglobin mass.

1 reference

12 October 2022

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Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Signalling hypoxia by HIF hydroxylases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Purification and characterization of hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1182/BLOOD-2009-05-189985

Identifiers

DOI

10.1182/BLOOD-2009-05-189985

1 reference

release_bip3ykxl25bh3ia7otnzxnieli

20 August 2017

Fatcat ID

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https://api.fatcat.wiki/v0/release/bip3ykxl25bh3ia7otnzxnieli

Fatcat

reference URL

mapped directly with Wikidata item

24 November 2022

based on heuristic

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