Search Results (1,331)

Metal ion intercalation into van der Waals gaps of layered materials is vital for large-scale electrochemical energy storage. Transition-metal sulfides, ABS₄ (where A and B represent Zr, Hf, and Ti as monolayers as anodes), are examined as lithium and sodium ion storage. Our study reveals that these monolayers offer exceptional performance for ion storage. The low diffusion barriers enable efficient lithium bonding and rapid separation while all ABS₄ phases remain semiconducting before lithiation and transition to metallic states, ensuring excellent electrical conductivity. Notably, the monolayers demonstrate impressive ion capacities: 1639, 1202, and 1119 mAh/g for Li-ions, and 1093, 801, and 671 mAh/g for Na-ions in ZrTiS₄, HfTiS₄, and HfZrS₄, respectively. Average voltages are 1.16 V, 0.9 V, and 0.94 V for Li-ions and 1.17 V, 1.02 V, and 0.94 V for Na-ions across these materials. Additionally, low migration energy barriers of 0.231 eV, 0.233 eV, and 0.238 eV for Li and 0.135 eV, 0.136 eV, and 0.147 eV for Na make ABS₄ monolayers highly attractive for battery applications. These findings underscore the potential of monolayer ABS₄ as a superior electrode material, combining high adsorption energy, low diffusion barriers, low voltage, high specific capacity, and outstanding electrical conductivity. Full article

Background/Objectives: BMS-202, is a potent small molecule with demonstrated antitumor activity. The study aimed to comprehensively characterize the physical and chemical properties of BMS-202 and evaluate its suitability for topical formulation, focusing on uniformity, stability and safety profiles. Methods: A range of analytical techniques were employed to characterize BMS-202. Scanning Electron Microscopy (SEM) was used to assess morphology, Differential Scanning Calorimetry (DSC) provided insights of thermal behavior, and Hot-Stage Microscopy (HSM) corroborated these thermal behaviors. Molecular fingerprinting was conducted using Raman spectroscopy and Fourier Transform Infrared (FTIR) spectroscopy, with chemical uniformity of the batch further validated by mapping through FTIR and Raman microscopies. The residual water content was measured using Karl Fisher Coulometric titration, and vapor sorption isotherms examined moisture uptake across varying relative humidity levels. In vitro safety assessments involved testing with skin epithelial cell lines, such as HaCaT and NHEK, and Transepithelial Electrical Resistance (TEER) to evaluate barrier integrity. Results: SEM revealed a distinctive needle-like morphology, while DSC indicated a sharp melting point at 110.90 ± 0.54 ℃ with a high enthalpy of 84.41 ± 0.38 J/g. HSM confirmed the crystalline-to-amorphous transition at the melting point. Raman and FTIR spectroscopy, alongside chemical imaging, confirmed chemical uniformity as well as validated the batch consistency. A residual water content of 2.76 ± 1.37 % (w/w) and minimal moisture uptake across relative humidity levels demonstrated its low hygroscopicity and suitability for topical formulations. Cytotoxicity testing showed dose-dependent reduction in skin epithelial cell viability at high concentrations (100 µM and 500 µM), with lower doses (0.1 µM to 10 µM) demonstrating acceptable safety. TEER studies indicated that BMS-202 does not disrupt the HaCaT cell barrier function. Conclusions: The findings from this study establish that BMS-202 has promising physicochemical and in vitro characteristics at therapeutic concentrations for topical applications, providing a foundation for future formulation development focused on skin-related cancers or localized immune modulation. Full article

Recent studies of the spread of substances penetrating the disrupted blood–brain barrier have revealed that the spread in the parenchyma surrounding a vessel has a complex character. In particular, a flow-like motion occurred for a short time that exhibits a smooth transition to diffusional spread. To address the possible physical background of such behavior, we created a system formed by a hydrogel medium with a channel filled by a marker solution, which can serve as a physical model mimicking the process of a substance passively spreading to the brain’s parenchyma when the blood–brain barrier is disrupted. The key result obtained in this work consists of the conclusion that the above-mentioned two-stage character of the spread process discovered in a previous biophysical experiment on the blood–brain opening in a living mouse may originate from the specificity of transport in porous soft matter with relaxation. We propose a mathematical model based on the extended Cattaneo equation, which reproduces our experimental data; determines the crossover time coinciding with that found in the biological system; and, therefore, provides a means of interpretation of this phenomenon. Full article

This article examines the potential of fuzzy set theory for analysing gradual changes in land use patterns within peri-urban areas. The primary objective of the study was to propose a methodology based on fuzzy set theory for the precise delineation of city boundaries and the identification and spatial localisation of the urban–rural transition zone. The analysis focused on elucidating the defining parameters of this area and the scope of land use changes within the urban–rural transition zone. The analysis employed data from four discrete time points. The data were collected in 2005, 2010, 2017, and 2022. The characteristics of the urban–rural transition zone were evaluated through an examination of historical data and the current land use patterns in regions experiencing direct urbanization pressure. The study demonstrated that, although spatial barriers remain, the city’s development has continued at a consistent pace. Between 2005 and 2010, the area of land classified as urban exhibited a 10% increase, with a further 7% increase observed in the subsequent period, spanning 2010 to 2017. In the most recent period under examination, the urban land area increased by 9%, a figure that is consistent with the rates observed in previous years. These results indicate the stability of urbanization processes in the analysed city, while also revealing significant changes in the limits of urban development and in the intensity of land use. The research project concentrated on the city of Olsztyn and the neighbouring suburban areas, which are subject to direct influence from the city’s expansion. The area under study encompasses 202.4 km² within an eight-km radius of the city centre. The authors of the study emphasized the necessity for systematic monitoring of changes in the transition zone between urban and rural areas. This is to ensure effective control of spatial development and ongoing adjustment of planning tools to effectively prevent uncontrolled expansion. The methodology used enabled the precise delimitation of urban development and the transition zone. This allowed for an in-depth analysis of changes in land use intensity. Full article

The transition to electric vehicles (EVs) plays a pivotal role in achieving decarbonization within the transportation sector. However, the widespread adoption of EVs faces multifaceted challenges, particularly concerning infrastructure development. This paper investigates the intersection of sustainability, decarbonization, and EV adoption, with a focus on identifying and analyzing the challenges associated with infrastructure deployment. Strictly adhering to the methodological principles and process of systematic literature reviews, this paper analyzes research spanning the fields of engineering, energy, computer science, environmental science, social sciences, and others to elucidate the barriers hindering EV adoption, ranging from technological limitations to regulatory complexities and market dynamics. Furthermore, it examines the critical role of infrastructure, encompassing charging networks, grid integration, and supportive policies, in facilitating EV uptake and maximizing environmental benefits. The findings are finally used to present the implications for theory, practice, and policies and to highlight the avenues for future research. Full article

Ecuador has significant solar potential, and the growing demand calls for sustainable energy solutions. Photovoltaic (PV) microgeneration in buildings is an ideal alternative. Identifying barriers to the widespread adoption of this technology is based on expert consultation and multi-criteria analysis, followed by proposals to overcome these challenges. The methodology of this study includes a systematic literature review (SLR), surveys of industry professionals, and statistical analysis of the collected data. The results highlight barriers such as the high initial cost, government-subsidized tariffs, bureaucratic processes and permits, ineffective regulations, limited awareness, lack of financing, distribution and operational network challenges, and insufficient government incentives. The proposed solutions suggest developing incentive policies to promote investment in PV microgeneration, training programs to enhance technical and cultural knowledge of solar energy, simplifying regulatory processes to facilitate project implementation, and providing accessible financing to reduce economic barriers. Additionally, the recommendations include the implementation of demonstration and outreach projects to showcase the feasibility and benefits of PV microgeneration, thus improving the social and technical acceptance of these systems. These actions aim to foster a faster and more effective energy transition in Ecuador. Full article

Seaports are pivotal nodes in global trade, under increasing pressure to expedite green transitions while navigating the complexities of modern economic and environmental challenges. This research investigates the intricate relationship between the resilience of port organizational ecosystems and the successful implementation of green transitions. Employing a combination of focus group interviews and participatory observation, the study explores the primary obstacles, particularly the insufficiency of managerial capacity, which hampers the integration of technological innovations. Challenges identified include outdated infrastructure, cybersecurity vulnerabilities, and the imperative for sustained investment in new technologies, along with the need to promote a culture of sustainability. Experts highlight the crucial role of managerial competencies and continuous learning in overcoming these barriers. Furthermore, the research underscores the importance of fostering strong partnerships among stakeholders, including government bodies, industry associations, and environmental organizations. The findings offer valuable insights for policymakers, port managers, and other stakeholders seeking to navigate the challenges for ensuring a sustainable future for the maritime sport organizational ecosystems and maritime industry. Full article

The transformation of healthcare from a fee-for-service model to value-based care is particularly crucial in managing complex and rare diseases like sarcoma, where data fragmentation and variability present significant challenges. This manuscript reviews strategies for structured and harmonized data integration—a critical precursor to precision medicine in sarcoma care. We demonstrate how standardizing data formats, ontologies, and coding systems enable seamless integration of clinical, economic, and patient-reported outcomes across institutions, paving the way for comprehensive predictive analytics. By establishing robust value-based healthcare (VBHC) frameworks through digital transformation and predictive models, including digital twins, we create the foundation for personalized sarcoma treatment and real-world-time clinical decision-making. The manuscript also addresses practical challenges, including the need for system standardization, overcoming regulatory and privacy concerns, and managing high costs. We propose actionable strategies to overcome these barriers and discuss the role of advanced analytics and future research directions that further enhance VBHC and precision medicine. This work outlines the necessary steps to build a cohesive, data-driven approach that supports the transition to precision medicine, fundamentally improving outcomes for sarcoma patients. Full article

The urban landscape of Kinshasa, Democratic Republic of Congo, faces significant mobility challenges, primarily stemming from rapid urbanization, overpopulation, and outdated infrastructure. These challenges necessitate the exploration of modern smart mobility concepts to improve traffic flow, road safety, and sustainability. This study investigates the potential of solutions such as Mobility-as-a-Service, car sharing, micro-mobility, Vehicle-as-a-Service, and electric vehicles in addressing these challenges. Through a comparative analysis of global implementations, this research identifies key success factors and barriers that inform the feasibility of integrating these solutions into Kinshasa’s unique socio-political and infrastructural context. The study presents a conceptual framework, supported by stakeholder analysis, for adapting these solutions locally. A detailed feasibility analysis considers technological, economic, social, environmental, and regulatory factors, offering a clear roadmap for implementation. Drawing on lessons from cities facing similar urban mobility challenges, the paper concludes with actionable recommendations and insights for policymakers and urban planners in Kinshasa. This research not only highlights the viability of smart mobility solutions in Kinshasa but also contributes to the broader discourse on sustainable urban development in rapidly growing cities. While smart mobility studies have largely focused on cities with developed infrastructure, there is a gap in understanding how these solutions apply to cities like Kinshasa with different infrastructural and socio-political contexts. Previous research has often overlooked the challenges of integrating smart mobility in rapidly urbanizing cities with underdeveloped transportation systems and financial constraints. This study fills that gap by offering a feasibility analysis tailored to Kinshasa, assessing smart mobility solutions for its traffic congestion and road safety issues. The smart mobility solutions studied—Mobility-as-a-Service (MaaS), car sharing, electric vehicles (EVs), and micro-mobility—were chosen for their ability to address Kinshasa’s key mobility challenges. MaaS reduces reliance on private vehicles, easing congestion and improving public transport. Car sharing offers affordable alternatives to vehicle ownership, essential in a city with income inequality. EVs align with sustainability goals by reducing emissions, while micro-mobility (bikes and e-scooters) improves last-mile connectivity, addressing public transit gaps. These solutions are adaptable to Kinshasa’s context and offer scalable, sustainable improvements for urban mobility. Full article

This study investigates the specific challenges and opportunities faced by organic farmers in Tamil Nadu, focusing on how region-specific practices influence the adoption and success of organic farming. It draws insights from a survey of 300 organic growers across five districts: Coimbatore, Dindigul, Erode, Tirupur, and Villupuram. This study is particularly relevant because there is a lack of comprehensive research on the specific challenges and opportunities faced by organic farmers in Tamil Nadu, with limited data on the long-term impact of government initiatives and region-specific management options, especially for smallholder farmers. Additionally, gaps exist in understanding the economic viability, market demand, and farmer perceptions of organic farming together with challenges like knowledge gaps, pest control, managing risks, and lower initial yields during the transition from conventional farming to organic farming. The research evaluated the factors affecting organic farming, including crop yield, the use of different organic formulations, the role of different information services, opportunities and challenges, and the impact on the perceived effectiveness of various agricultural outcomes. Various statistical analyses were performed, including K-means clustering, Poisson regression, and chi-square test. The results revealed significant variations in the adoption of various organic inputs and regionally practiced organic formulations. Crop residues (82.67%), Jeevamrith (78.33%), Amudhakaraisal (77.00%), and 3G-Extracts (74.00%) have high adoption rates, reflecting their perceived effectiveness and accessibility among farmers. However, the adoption of microbial bio-inputs such as Trichoderma viride (1.00%), Acetobacter spp. (19.00%), Azophos (consortium of phosphorus fixing microbes) (26.33%), and Azospirillum spp. (28.67%) was notably poor despite their known benefits for soil health and crop yield. The chi-square test also highlighted key challenges faced by farmers in adopting organic farming practices. The Poisson regression analysis showed significant positive impacts on crop growth and yield, disease resistance, insect control, overall plant health, and input efficiency due to organic farming. The study’s insights are essential for developing targeted strategies to overcome barriers, supporting the growth and sustainability of organic farming. Addressing these challenges and promoting effective information channels will better equip stakeholders to support organic growers, contributing to more resilient and productive agricultural systems in the region. Full article

The integration of sustainable practices in tourism is increasingly critical, given the sector’s substantial environmental and social impacts. Although the need for innovation management to promote sustainable tourism is widely recognized, various barriers hinder its effective implementation. This study employs the Decision-Making Trial and Evaluation Laboratory (DEMATEL) methodology to systematically examine these barriers, identifying their interconnections and assessing their broader implications. The findings indicate that a short-term focus and financial constraints are the primary effect barriers to implementing innovation management in sustainable tourism. Their prominence as endpoints in the flow of impact within the model of interconnected barriers developed in this study underscores the need to further address the deeper, cause-related barriers that propagate these effects, such as inadequate leadership support, resistance to change, poor stakeholder communication and collaboration, insufficient knowledge and skills, and restrictive regulatory policies. Additionally, industry-specific challenges like a fragmented industry structure and fluctuating market conditions exacerbate these difficulties. Therefore, a comprehensive, holistic approach is essential for transitioning the tourism sector towards sustainable practices through innovation management and overcoming inherent financial and strategic barriers. This study advocates adopting the recently published Management System Standard ISO 56001:2024 as a structured innovation management framework capable of systematically and holistically mitigating these barriers. By analyzing the cause-and-effect relationships among the identified barriers, this study ultimately provides valuable insights that aid stakeholders—including policymakers, business leaders, and community representatives—in devising more effective, inclusive, and forward-thinking approaches to innovation in sustainable tourism. This is crucial for fostering a tourism sector that is not only economically beneficial but also environmentally responsible and socially equitable. Full article

Melanoma, a deadly form of skin cancer, has seen improved survival rates due to advances in diagnosis and treatment, yet the need for further improvement remains critical. Tumor-associated antigens, such as PRAME (Preferentially Expressed Antigen in Melanoma), offer promising avenues for enhanced diagnostic precision, prognostic assessment, and targeted immunotherapy. PRAME, a cancer testis antigen, is selectively expressed in various cancers, including melanoma, and plays a key role in promoting tumorigenesis through inhibition of retinoic acid signaling, epithelial-to-mesenchymal transition, and immune evasion. This review explores the diagnostic utility of PRAME in distinguishing melanoma from benign nevi, its prognostic value in aggressive melanoma subtypes, and its potential as a therapeutic target in cancer vaccines and adoptive T-cell therapies. While PRAME-targeted therapies face challenges such as tumor heterogeneity and immune suppression, ongoing research aims to overcome these barriers, offering hope for more effective melanoma treatments. Full article

DNA-RNA hybrid duplexes play essential roles during the reverse transcription of RNA viruses and DNA replication. The opening and conformation changes of individual base pairs are critical to their biological functions. However, the microscopic mechanisms governing base pair closing and opening at the atomic level remain poorly understood. In this study, we investigated the thermodynamic and kinetic parameters of the dA-rU base pair in a DNA-RNA hybrid duplex using 4 μs all-atom molecular dynamics (MD) simulations at different temperatures. Our results showed that the thermodynamic parameters of the dA-rU base pair aligned with the predictions of the nearest-neighbor model and were close to those of the AU base pair in RNA. The temperature dependence of the average lifetimes of both the open and the closed states, as well as the transition path times, were obtained. The free-energy barrier for a single base pair opening and closing arises from an increase in enthalpy due to the disruption of the base-stacking interactions and hydrogen bonding, along with an entropy loss attributed to the accompanying restrictions, such as torsional angle constraints and solvent viscosity. Full article

Sepsis is a complex clinical syndrome characterized by an uncontrolled inflammatory response to an infection that may result in septic shock and death. Recent research has revealed a crucial link between sepsis and alterations in the gut microbiota, showing that the microbiome could serve an essential function in its pathogenesis and prognosis. In sepsis, the gut microbiota undergoes significant dysbiosis, transitioning from a beneficial commensal flora to a predominance of pathobionts. This transformation can lead to a dysfunction of the intestinal barrier, compromising the host’s immune response, which contributes to the severity of the disease. The gut microbiota is an intricate system of protozoa, fungi, bacteria, and viruses that are essential for maintaining immunity and metabolic balance. In sepsis, there is a reduction in microbial heterogeneity and a predominance of pathogenic bacteria, such as proteobacteria, which can exacerbate inflammation and negatively influence clinical outcomes. Microbial compounds, such as short-chain fatty acids (SCFAs), perform a crucial task in modulating the inflammatory response and maintaining intestinal barrier function. However, the role of other microbiota components, such as viruses and fungi, in sepsis remains unclear. Innovative therapeutic strategies aim to modulate the gut microbiota to improve the management of sepsis. These include selective digestive decontamination (SDD), probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation (FMT), all of which have shown potential, although variable, results. The future of sepsis management could benefit greatly from personalized treatment based on the microbiota. Rapid and easy-to-implement tests to assess microbiome profiles and metabolites associated with sepsis could revolutionize the disease’s diagnosis and management. These approaches could not only improve patient prognosis but also reduce dependence on antibiotic therapies and promote more targeted and sustainable treatment strategies. Nevertheless, there is still limited clarity regarding the ideal composition of the microbiota, which should be further characterized in the near future. Similarly, the benefits of therapeutic approaches should be validated through additional studies. Full article

Transitioning from petrol or gas vehicles to electric vehicles (EVs) poses significant challenges in reducing emissions, lowering operational costs, and improving energy storage. Wireless charging EVs offer promising solutions to wired charging limitations such as restricted travel range and lengthy charging times. This paper presents a comprehensive approach to address the challenges of wireless power transfer (WPT) for EVs by optimizing coupling frequency and coil design to enhance efficiency while minimizing electromagnetic interference (EMI) and heat generation. A novel coil design and adaptive hardware are proposed to improve power transfer efficiency (PTE) by defining the optimal magnetic resonant coupling WPT and mitigating coil misalignment, which is considered a significant barrier to the widespread adoption of WPT for EVs. A new methodology for designing and arranging roadside lanes and facilities for dynamic wireless charging (DWC) of EVs is introduced. This includes the optimization of transmitter coils (TCs), receiving coils (RCs), compensation circuits, and high-frequency inverters/converters using the partial differential equation toolbox (pdetool). The integration of wireless charging systems with smart grid technology is explored to enhance energy distribution and reduce peak load issues. The paper proposes a DWC system with multiple segmented transmitters integrated with adaptive renewable photovoltaic (PV) units and a battery system using the utility main grid as a backup. The design process includes the determination of the required PV array capacity, station battery sizing, and inverters/converters to ensure maximum power point tracking (MPPT). To validate the proposed system, it was tested in two scenarios: charging a single EV at different speeds and simultaneously charging two EVs over a 1 km stretch with a 50 kW system, achieving a total range of 500 km. Experimental validation was performed through real-time simulation and hardware tests using an OPAL-RT platform, demonstrating a power transfer efficiency of 90.7%, thus confirming the scalability and feasibility of the system for future EV infrastructure. Full article