Search Results (271)

Background: The objective was to analyze the budgets invested in prisons by the member states of the Council of Europe (CoE) and the relationships between the global cost, the cost incurred per single inmate, the number of inmates per 100,000 inhabitants (PPR), the gross domestic product (GDP) and per capita GDP. Methods: The data relating to the variables considered for the year 2020 were obtained from the SPACE-I 2021 of the CoE, the World Bank/OECD, and Eurostat. Regression models were used to evaluate the relationships between the PPR and the GDP, the daily cost per prisoner and per capita GDP, and between the PPR and the per capita GDP. A multiple correspondence analysis was performed to evaluate associations between the PPR, EU membership, cost per day, cost rate, geographical area, and inmate gender. Results: The daily expenditure per inmate in northern European countries reaches very high values, respectively: EUR 330.6 (Norway) and EUR 303 (Sweden), while, in the eastern countries, the values drop sharply (EUR 6.50 in Bulgaria and EUR 8.08 in Azerbaijani). The lowest PPR values are found in northern European countries, and the highest in the following countries: Russia, Turkey, Georgia, and Azerbaijan. Conclusions: Countries with a higher GDP per capita tend to have lower prison population rates and to invest larger amounts of funds for prison systems. Full article

Peste des Petits Ruminants (PPR) disease is widely distributed in Africa. Live attenuated PPR vaccines are produced using approved Nigeria 75/1 and Sungri/96 strains by the World Organisation of Animal Health (WOAH) to control the disease. These PPR vaccines are very efficacious; however, the main challenge is the maintaining of the cold chain during vaccine distribution and delivery. This study evaluated the thermotolerance of freeze-dried and reconstituted PPR Nigeria 75/1 vaccines from vaccine manufacturers using eight stabilizer formulations (lactalbumin hydrolysate and sucrose, sucrose and peptone, Weybridge medium, trehalose, Lactose and N-Z Amine, lactalbumin hydrolysate, sucrose and L glutamine, skimmed milk, and lactalbumin hydrolysate, maltose and gelatine). Aliquots of the reconstituted PPR vaccine batches were titrated after 2, 4, and 6 h of storage at 4 °C and 40 °C. The PPR vaccines were also titrated after storage at 40 °C and 45 °C for 3 and 5 days. The results showed that reconstituted PPR vaccine stabilized with lactalbumin hydrolysate–sucrose promoted tolerance at 40 °C for 6 h. It was also noted that all reconstituted PPR vaccine formulations except the formulation stabilized with lactalbumin hydrolysate–maltose–gelatine maintained the titre above a 10^2.5 TCID₅₀/dose after 4 h of storage at 4 °C. Furthermore, the results showed that the PPR vaccine formulation containing lactalbumin hydrolysate sucrose was as the only one that maintained the titres above 10^2.5 TCID₅₀/dose after storage at 45 °C for 5 days, with a titre loss of 10^0.95 TCID₅₀/dose. Therefore, vaccine manufacturers producing PPR vaccines for use in tropical field regions could preferably use lactalbumin hydrolysate–sucrose stabilizer in vaccine formulation. Full article

Reaumuria genus (Tamaricaceae) is widely distributed across the desert and semi-desert regions of Northern China, playing a crucial role in the restoration and protection of desert ecosystems. Previous studies mainly focused on the physiological responses to environmental stresses; however, due to the limited availability of genomic information, the underlying mechanism of morphological and ecological differences among the Reaumuria species remains poorly understood. In this study, we presented the first catalog of expressed transcripts for R. kaschgarica, a sympatric species of xerophyte R. soongorica. We further performed the pair-wise transcriptome comparison to determine the conserved and divergent genes among R. soongorica, R. kaschgarica, and the relict recretohalophyte R. trigyna. Annotation of the 600 relatively conserved genes revealed that some common genetic modules are employed by the Reaumuria species to confront with salt and drought stresses in arid environment. Among the 250 genes showing strong signs of positive selection, eight pentatricopeptide repeat (PPR) superfamily protein genes were specifically identified, including seven PPR genes in the R. soongorica vs. R. trigyna comparison and one PPR gene in the R. kaschgarica vs. R. trigyna comparison, while the cyclin D3 gene was found in the R. soongorica vs. R. trigyna comparison. These findings suggest that genetic variations in PPR genes may affect the fertility system or compromise the extent of organelle RNA editing in R. trigyna. The present study provides valuable genomic information for R. kaschgarica and preliminarily reveals the conserved genetic bases for the abiotic stress adaptation and interspecific divergent selection in the Reaumuria species. The rapidly evolved PPR and cyclin D3 genes provide new insights on the endangerment of R. trigyna and the leaf length difference among the Reaumuria species. Full article

Peste des petits ruminants virus (PPRV), which is the only member of the Morbillivirus caprinae species and belongs to the genus Morbillivirus within the Paramyxoviridae family, causes the highly contagious viral sickness “Peste des petits ruminants (PPR).” PPR is of serious economic significance for small ruminant production, particularly in Africa. Control of this critical disease depends highly on successful vaccination against the PPRV. An in-depth understanding of the genetic evolution of the live-attenuated PPR vaccine Nigeria 75/1 strain used in Africa is essential for the successful eradication of this disease by 2030. Therefore, this study investigated the possible genetic evolution of the PPR vaccine produced by various African laboratories compared with the master seed available at AU-PANVAC. RT-PCR was performed to amplify a segment of the hypervariable C-terminal part of the nucleoprotein (N) from commercial batches of PPR vaccine Nigeria 75/1 strain. The sequences were analyzed, and 100% nucleotide sequence identity was observed between the master seed and vaccines produced. The results of this study indicate the genetic stability of the PPR vaccine from the Nigeria 75/1 strain over decades and that the vaccine production process used by different manufacturers did not contribute to the emergence of mutations in the vaccine strain. Full article

In 2013, the second outbreak of peste des petits ruminants occurred in China, leading to a spillover in more than 20 provinces and municipalities over the next few months. Thereafter, the epidemic situation was stable owing to strict prevention and control measures. In February 2024, several bharals and argali with suspected symptoms of PPR were discovered in Rutog country, Tibet Autonomous Region. Samples collected from these animals were delivered to our laboratory for diagnosis; the results of fluorescence quantitative reverse-transcription (RT) PCR indicated that all samples were positive for PPR viral RNA. The N and F gene fragments were amplified successfully via RT-PCR, and these results confirmed that these animals were infected with PPRV. A PPRV strain (subsequently named ChinaTibet2024) was sequenced, and its genome length was 15,954 nucleotides. A phylogenetic tree analysis using N and F genes and viral genomes showed that the ChinaTibet2024 genome was classified into lineage IV of the PRRV genotypes. The genome of the ChinaTibet2024 strain was found to be closely related to PPRVs isolated in China between 2013 and 2014. A base insertion and a base deletion were detected in the M gene 5′ untranslated region. Results indicated that the prevalent PPRV strains in China did not show significant changes and that special attention should be paid to the surveillance of wild animals as an important part of PPR prevention and control. Full article

Accurately identifying ecological compensation areas and scientifically determining appropriate compensation amounts are crucial for establishing a robust ecological compensation mechanism, which in turn is key to promoting the coordinated development of ecological protection and high-quality economic growth. This study innovatively proposes a framework for ecological compensation termed “Accounting of Ecosystem Services Value–Identification of Priorities for Payers and Recipients–Calculation of Ecological Compensation Amount (ESV–PPR–ECA)”. It utilizes the InVEST model and the emergy method to assess the value of ecosystem services, constructs the Ecosystem Payment and Recipient Priority Sequence (EPRPS) Model to identify the payers, recipients, and their priorities for ecological compensation, and employs the conversion factor method to calculate the Ecological Compensation Amount (ECA). This framework aims to address the questions of “How should compensation be provided?”, “Who should compensate whom?”, and “How much compensation is necessary?”, ensuring the optimal use of ecological compensation funds and providing a scientific basis for inter-regional ecological compensation. The study’s findings indicate that the total Ecological Compensation Amount for the Yellow River Delta in 2020 was 3.848 billion RMB, with the total amount receivable being 4.032 billion RMB and the total amount payable being 184 million RMB. The compensation funds should be prioritized for tideland and the Yellow River, and venture, cropland and industrial land should be the first to contribute compensation. Additionally, the Ecosystem Service Value of the Yellow River Delta showed a declining trend from 2015 to 2020, underscoring the urgent need to establish a horizontal compensation mechanism for the region. Such a mechanism would incentivize environmental protection and the construction of ecological civilization, ultimately enhancing ecosystem service functions. Therefore, we recommend the implementation of horizontal fiscal transfers, where financial assistance is provided from paying areas to recipient areas, offering a scientific reference for the establishment of a horizontal compensation mechanism within the Yellow River Delta. Full article

The leaf is not only the main site of photosynthesis, but also an important organ reflecting plant salt tolerance. Discovery of salt-stress-responding genes in the leaf is of great significance for the molecular improvement of salt tolerance in wheat varieties. In this study, transcriptome sequencing was conducted on the leaves of salt-tolerant wheat germplasm CH7034 seedlings at 0, 1, 6, 24, and 48 h after NaCl treatment. Based on weighted gene correlation network analysis of differentially expressed genes (DEGs) under salt stress, 12 co-expression modules were obtained, of which, 9 modules containing 4029 DEGs were related to the salt stress time-course. These DEGs were submitted to the Wheat Union database, and a total of 904,588 SNPs were retrieved from 114 wheat germplasms, distributed on 21 wheat chromosomes. Using the R language package and GAPIT program, association analysis was performed between 904,588 SNPs and leaf salt injury index of 114 wheat germplasms. The results showed that 30 single nucleotide polymorphisms (SNPs) from 15 DEGs were associated with salt tolerance. Then, nine candidate genes, including four genes (TaBAM, TaPGDH, TaGluTR, and TaAAP) encoding enzymes as well as five genes (TaB12D, TaS40, TaPPR, TaJAZ, and TaWRKY) encoding functional proteins, were identified by converting salt tolerance-related SNPs into Kompetitive Allele-Specifc PCR (KASP) markers for validation. Finally, interaction network prediction was performed on TaBAM and TaAAP, both belonging to the Turquoise module. Our results will contribute to a further understanding of the salt stress response mechanism in plant leaves and provide candidate genes and molecular markers for improving salt-tolerant wheat varieties. Full article

Understanding the influence of gap distribution characteristics on the mechanical properties of circular concrete-filled steel tubes (CCFSTs) under bending load is important for stability and support design in engineering projects. In this study, the improved cohesive zone model considering friction was used to describe the mechanical behavior of mortar interfaces. Meanwhile, the concrete damage plastic model and isotropic elastoplastic model were applied for core concrete and steel tubes. The improved cohesive zone model has a unified potential function that governs the Mode I and Mode II failure processes of mortar interfaces to realize the mechanical interaction between concrete and steel. A smooth frictional function was utilized in the elastic stage to calculate the accurate frictional effect. Furthermore, the capability of the model in addressing unloading and reloading was verified, and the fracture energy varied accordingly during the cyclic loading. Then, the mechanical response of CCFSTs was investigated under bending loads by setting different gap sizes and angles between the gap and loading direction. The results show that under three-point bending, the equivalent plastic strains at the middle part of CCFSTs are much larger and the peak bearing forces are much lower than the other degrees when the angles between the coronal gap axis and loading direction equal 0° and 180°. In addition, the order of the peak bearing forces, from highest to lowest, is when the height of the coronal-cap gap increases from 0.0 mm to 2.5 mm, 5.0 mm, and 7.5 mm. The significant effect makes it inappropriate to ignore the weakening of the structural performance caused by coronal gaps in structural design. Full article

Background/Objectives: Oligometastatic prostate cancer (OMPC) represents an early stage of metastatic disease characterized by a limited number of lesions. Recent advancements in imaging and treatment have revived interest in personalized therapies, including metastasis-directed radiotherapy (OMDRT) and primary prostate radiotherapy (PPR). This study evaluates the impact of OMDRT timing and the role of PPR on survival outcomes in OMPC patients; Methods: In this retrospective cohort study, 82 patients with OMPC who underwent OMDRT between 2010 and 2019 were analyzed. Patients were classified based on OMDRT timing (early vs. late) and disease type (synchronous vs. metachronous). Progression-free survival (PFS) and overall survival (OS) were the primary endpoints, assessed via Kaplan-Meier analysis and Cox proportional hazards models; Results: Among the patients, 36 (43.9%) had synchronous and 46 (56.1%) had metachronous OMD. With a median follow-up of 32 months, the 5-year PFS and OS rates were 77.5% and 88.5%, respectively. Early OMDRT significantly improved PFS (HR 0.461, 95% CI: 0.257–0.826, p = 0.009) and OS (HR 0.219, 95% CI: 0.080–0.603, p = 0.003). Subgroup analysis showed the most favorable outcomes for synchronous OMD patients receiving early OMDRT, with a median PFS of 22.2 months and a 5-year survival rate of 42.1%. The treatment of the primary prostate provided a survival benefit in the OS of synchronous OMD patients (5-year 83.1% vs. 50%, p = 0.025), and there was a further improvement in OS after PPR (5-year 87.7% vs. 50%, p = 0.015). Conclusions: Early OMDRT significantly enhances survival outcomes in OMPC, in both synchronous and metachronous cases. The integration of PPR can further improve results, emphasizing the importance of early intervention and personalized treatment strategies. To more definitively clarify our findings across various clinical situations, further studies with larger cohorts or prospective designs are necessary. Full article

By adjusting the two wall angles of the orthogonal hybrid honeycomb (OHH), the tunable Poisson’s ratio change from negative to positive values and the variation in stiffness can be achieved. To effectively analyze its static and dynamic characteristics, a two-dimensional equivalent Kirchhoff–Love model (2D-EKM) is established based on the variational asymptotic method (VAM).This model aids in effectively addressing the complexity arising from anisotropy. The obtained equivalent orthotropic properties are validated through unit-cell uniaxial compression tests and three-point bending experiments on 3D-printed specimens. The numerical simulation results suggest that the VAM-based 2D-EKM can predict the in-plane and out-of-plane static behaviors of OHH panels, with a maximum error below 10%. Particularly in the dynamic analysis of a four-sided fixed OHH panel, the analysis time required by 2D-EKM is only 0.37% of that needed for the 3D FE model. The OHH-ZPR panel exhibits exceptional resistance to deformation, with a maximum deformation under in-plane tension reaching only 27% of that in the OHH-PPR panel. Moreover, each 1% increase in the height–length ratio results in a respective increase of 275.62% and 281.93% in equivalent bending stiffness along both directions. This highlights that enhancing this ratio effectively boosts the fundamental frequency compared to the elastic modulus ratio, effectively prevents low-frequency resonance occurrences, and offers vital insights for the design and optimization of OHH panels. Full article

Particle plasmon resonance (PPR), or localized surface plasmon resonance (LSPR), utilizes intrinsic resonance in metal nanoparticles for sensor fabrication. While diffraction grating waveguides monitor bioaffinity adsorption with out-of-plane illumination, integrating them with PPR for biomolecular detection schemes remains underexplored. This study introduces a label-free biosensing platform integrating PPR with a diffraction grating waveguide. Gold nanoparticles are immobilized on a glass slide in contact with a sample, while a UV-assisted embossed diffraction grating is positioned opposite. The setup utilizes diffraction in reflection to detect changes in the environment’s refractive index, indicating biomolecular binding at the gold nanoparticle surface. The positional shift of the diffracted beam, measured with varying refractive indices of sucrose solutions, shows a sensitivity of 0.97 mm/RIU at 8 cm from a position-sensitive detector, highlighting enhanced sensitivity due to PPR–diffraction coupling near the gold nanoparticle surface. Furthermore, the sensor achieved a resolution of 3.1 × 10⁻⁴ refractive index unit and a detection limit of 4.4 pM for detection of anti-DNP. The sensitivity of the diffracted spot was confirmed using finite element method (FEM) simulations in COMSOL Multiphysics. This study presents a significant advancement in biosensing technology, offering practical solutions for sensitive, rapid, and label-free biomolecule detection. Full article

Water hammer (WH) is a critical phenomenon in fluid-filled piping systems that can lead to severe pressure surges and structural damage. The characteristics of the pipe material, geometry, and support conditions play a crucial role in the fluid–structure interaction (FSI) during WH events. This study investigates the impact of various pipe parameters, including material, length, thickness, and diameter, on the WH behavior using an FSI-based numerical approach. A comprehensive computational model was developed based on the algorithm presented in Delft Hydraulics Benchmark Problem (A) to simulate the WH phenomenon in pipes made of different materials, such as steel, copper, ductile iron, PPR (polypropylene random copolymer), and GRP (glass-reinforced plastic). This study examines the influence of pipe parameters on WH performance in pipelines, utilizing FSI to analyze the phenomenon. The results show that the pipe material has a significant influence on the pressure wave speed, stress wave propagation, and the overall system response during WH. Pipes with lower modulus of elasticity, such as PPR and GRP, exhibit lower pressure wave speeds but higher stress wave speeds compared with steel pipes. Increasing the elastic modulus, pipe wall thickness, length, and diameter enhances the pipe’s stiffness and impacts the timing, magnitude of pressure surges, and the likelihood of cavitation. The findings of this study provide valuable insights into the design and mitigation of WH in piping systems. Full article

In recent years, graph-based learning methods have gained significant traction in point-of-interest (POI) recommendation systems due to their strong generalization capabilities. These approaches commonly transform user check-in records into graph-structured data and leverage graph neural networks (GNNs) to model the representations of both POIs and users. Despite their effectiveness, GNNs face inherent limitations in message passing, which can impede the deep extraction of meaningful representations from the graph structure. To mitigate this challenge, we introduce a novel framework, Multi-view Contextual Graphs via Convolutional Neural Networks for Point-of-Interest Recommendation (MCGRec). The MCGRec framework consists of three primary components. Firstly, it employs a personalized PageRank (PPR) sampling technique based on super nodes to transform the graph-structured data into a grid-like feature matrix. This step is crucial as it prepares the data for subsequent processing by convolutional neural networks (CNNs), which are adept at extracting spatial features from grid-like structures. Secondly, a CNN is utilized to extract the representations of POIs from the constructed feature matrix. The usage of CNNs enables the capture of local patterns and hierarchical features within the data, which are essential for accurate POI representation. Lastly, MCGRec incorporates a novel approach for estimating user preferences that integrates both geographical and temporal factors, thereby providing a more comprehensive model of users’ behaviors. To evaluate the effectiveness of our proposed method, we conduct extensive experiments on real-world datasets. Our results demonstrate that MCGRec outperforms state-of-the-art POI recommendation methods, showcasing its superiority in terms of recommendation accuracy. Full article

This research investigates novel polymeric composite materials for automotive interior trim applications. The composites utilize recycled polypropylene (PPr) matrix and carboxymethylcellulose (CMC) as filler (PPr/CMC: 100/0, 95/5, and 90/10 wt.%). The materials were processed by extrusion and injection molding. Considering their intended application, the composites were evaluated for resistance to key climatic factors, i.e., temperature, humidity, and UV radiation. In addition, structural analyses and FTIR analyses were performed to assess potential heterogeneity and thermal stability. Following FTIR tests, the incorporation of carboxymethyl cellulose in polypropylene is confirmed by the detection of characteristic CMC bands for -OH, C=O, and C-O-C groups. The results indicate slight structural heterogeneity in the 5% and 10% CMC composites. However, no thermal distortions were observed in either the composites or the PPr matrix itself. The behavior of PPr/CMC composites under the action of the mentioned climatic factors has been assessed from the variation of dielectric characteristics with frequency. The strong polarization of CMC leads to a sharp increase in composites electrical conductivity after submersion in water for 480 h, suggesting weakening of the composite structure. After exposure to UV radiation, a sharp increase in conductivity is observed even after the first cycle (72 h) of UV radiation. Following the experimental results obtained in our study, it is recommended to use the PPr +10% CMC composite for obtaining different interior ornaments (carpets, supports, etc.). At the same time, the use of these materials also has the advantage of lightening the mass of the vehicle due to their lower density than polymers. Full article

Polyrotaxane (PR) has garnered increasing attention due to its unique structure and exceptional performance. In this study, a polypseudorotaxane (PPR) initiator was prepared through the self-assembly of bromine-capped Pluronic F68 and β-cyclodextrins (β-CD) in water. Polyrotaxane-containing triblock copolymers (PR copolymers) were successfully synthesized by atom transfer radical polymerization (ATRP) of butyl methacrylate (BMA) using the PPR initiator in the presence of Cu(I)Br/PMDETA. The structure of the PR copolymers was thoroughly characterized using infrared spectroscopy (IR), proton nuclear magnetic resonance (¹H NMR), and gel permeation chromatography (GPC). The mobility of β-CD in the PR copolymers was demonstrated through dielectric measurements. Mechanical tests, including tensile strength assessments, thermal mechanical analysis, and dynamic mechanical analysis, confirmed the excellent mechanical properties and good processability of the PR copolymer, attributed to the PBMA blocks. Furthermore, the mechanical properties were found to be modulated by the motility of the threaded β-CDs. Consequently, the superior mechanical properties and the high mobility of the threaded β-CDs suggest promising potential for the as-prepared PR polymer in various advanced applications. Full article