Search Results (59)

This study rigorously investigates the impact of COVID-19 on Tunisian stock market volatility. The investigation spans from January 2020 to December 2022, employing a GJR-GARCH model, bias-corrected wavelet analysis, and an ARDL approach. Specific variables related to health measures and government interventions are incorporated. The findings highlight that confirmed and death cases contribute significantly to the escalation in TUNINDEX volatility when using both the conditional variance and the realized volatility. Interestingly, aggregate indices related to government interventions exhibit substantial impacts on the realized volatility, indicating a relative resilience of the Tunisian stock market amidst the challenges posed by COVID-19. However, the application of the bias-corrected wavelet analysis yields more subtle outcomes in terms of the correlations of both measures of volatility to the same metrics. Our econometric implications bear on the application of such a technique, as well as on the use of the realized volatility as an accurate measure of the “true” value of volatility. Nevertheless, the measures and actions undertaken by the authorities do not exclude fear and insecurity from investors due to another virus or any other crisis. The positive and long-term impact on the volatility of US equity market uncertainty, VIX, economic policy uncertainty (EPU), and the infectious disease EMV tracker (IDEMV) is obvious through the autoregressive distributed lag model (ARDL). A potential vulnerability of the Tunisian stock market to future shocks is not excluded. Government and stock market authorities should grapple with economic and financial fallout and always instill investor confidence. Importantly, our results put mechanisms such as overreaction to public news and (in)efficient use of information under test. Questioning the accuracy of announcements is then recommended. Full article

A comparison of the accuracy of intraocular lens (IOL) power calculation formulae, including SRK/T, HofferQ, Holladay 1, Haigis, MM, Barrett Universal II (BUII), Emmetropia Verifying Optical (EVO), and AS-OCT ray tracing, was performed. One hundred eyes implanted with either the Rayone EMV RAO200E (Rayner Intraocular Lenses Limited, Worthing, UK) or the Artis Symbiose (Cristalens Industrie, Lannion, France) IOL were included. Biometry was obtained using IOLMaster 700 (Carl Zeiss Meditec AG, Jena, Germany) and MS-39 AS-OCT (CSO, Firenze, Italy). Mean (MAE) and median (MedAE) absolute errors and percentage of eyes within ±0.25D, ±0.50D, ±0.75D, and ±1.00D of the target were compared, with ±0.75D considered a key metric. The highest percentage within ±0.75D was found with MM (96%) followed by the Haigis (94%) for the enhanced monofocal IOL. SRK/T (94%) had the highest percentage within ±0.75D, followed by Holladay 1, MM, BUII, and ray tracing (all 90%) for the multifocal IOL. No statistically significant difference in MAE was found with both IOLs. EVO showed the lowest MAE for the enhanced monofocal and ray tracing for the multifocal IOL. EVO and ray tracing showed the lowest MedAE for the two respective IOLs. A similar performance with high accuracy across formulae was found. MM and ray tracing appear to have similar accuracy to the well-established formulae and displayed a high percentage of eyes within ±0.75D. Full article

Many manufacturing industries today are adopting sustainable production methods in response to environmental regulations and efforts. One of the typical criteria they consider is the United Nations has set global objectives (Sustainable Development Goals: SDGs) designed to address various social, economic, and environmental challenges. “Ensuring sustainable consumption and production patterns” (Goal 12) is one of these goals. As a result, not only are manufacturers interested in sustainable products, but consumers are also showing increased interest. Consequently, the market size for sustainable products is also on the rise. This study aims to examine the mechanisms of how to improve customer loyalty of South Korean consumers who have experience purchasing sustainable apparel to vitalize the sustainable product market in Korea. Specifically, this study reveals the impact of perceived value (PV) on loyalty (LY), focusing on the mediating effects of satisfaction (SAT) and trust (TR). The analysis finds that functional value (FV), emotional value (EMV), and green value (GV) have significant direct effects on LY. Additionally, SAT and TR have significant mediating effects between PV and LY, and there is no difference in the strength of the indirect effects of SAT and TR in the relationship between FV, EMV, GV, and LY. This study extends the theoretical background of the mechanisms enhancing loyalty to sustainable apparel through the verification of parallel mediating effects. Furthermore, it is expected that these insights will serve as a direction for the operational strategies of sustainable apparel manufacturing companies. Full article

Background: The release of microvesicles (MVs) is an essential phenomenon for inter-cellular signaling in health and disease. The role of MVs in cancer is multidimensional and includes cancer cell survival, proliferation, and invasion. In this prospective study, we analyzed MV levels in colorectal cancer patients and assessed the importance of MV release in early-stage colorectal cancer and survival. Methods: This study included 98 patients and 15 controls. The characterization of MVs from human plasma was performed by flow cytometry using monoclonal antibodies. Results: The levels of total MVs and MUC-1-positive, tissue factor (TF)-positive, and endothelial cell-derived MVs (EMVs) were statistically significantly higher in the colon cancer patients than in the controls (p < 0.001). Furthermore, the subgroup of patients with very early-stage colorectal cancer also had statistically significant differences in the levels of the abovementioned MVs compared to the controls (p < 0.01). Highly differentiated tumors had lower levels of MUC-1-positive MVs (p < 0.02), EMVs (p < 0.002), and EMV/TF combinations (p < 0.001) versus those with tumors with low/intermediate differentiation. Conclusions: Our data demonstrate that the analysis of circulating MV levels in plasma could possibly become a tool for the early diagnosis of colon cancer at a very early stage of the disease. Full article

This work evaluated in vivo an experimental-multivalent-vaccine (EMV) based on three Porcine Respiratory Complex (PRC)-associated antigens: Porcine Circovirus Type 2 (PCV2), M. hyopneumoniae (Mhyop) and M. hyorhinis (Mhyor), microencapsulated with sulfated chitosan (M- ChS + PRC-antigens), postulating chitosan sulphate (ChS) as a mimetic of the heparan sulfate receptor used by these pathogens for cell invasion. The EMV was evaluated physicochemically by SEM (Scanning-Electron-Microscopy), EDS (Energy-Dispersive-Spectroscopy), Pdi (Polydispersity-Index) and zeta potential. Twenty weaned pigs, distributed in four groups, were evaluated for 12 weeks. The groups 1 through 4 were as follows: 1-EMV intramuscular-route (IM), 2-EMV oral-nasal-route (O/N), 3-Placebo O/N (M-ChS without antigens), 4-Commercial-vaccine PCV2-Mhyop. qPCR was used to evaluate viral/bacterial load from serum, nasal and bronchial swab and from inguinal lymphoid samples. Specific humoral immunity was evaluated by ELISA. M-ChS + PRC-antigens measured between 1.3–10 μm and presented low Pdi and negative zeta potential, probably due to S (4.26%). Importantly, the 1-EMV protected 90% of challenged animals against PCV2 and Mhyop and 100% against Mhyor. A significant increase in antibody was observed for Mhyor (1-EMV and 2-EMV) and Mhyop (2-EMV), compared with 4-Commercial-vaccine. No difference in antibody levels between 1-EMV and 4-Commercial-vaccine for PCV2-Mhyop was observed. Conclusion: The results demonstrated the effectiveness of the first EMV with M-ChS + PRC-antigens in pigs, which were challenged with Mhyor, PCV2 and Mhyop, evidencing high protection for Mhyor, which has no commercial vaccine available. Full article

BCR-ABL tyrosine kinase inhibitors (TKIs) are effective drugs in the treatment of patients with chronic myeloid leukemia. However, based on clinical studies, ponatinib was associated with the development of thrombotic complications. Since endothelial cells (ECs) regulate blood coagulation, their abnormal phenotype may play a role in the development of thrombotic events. We here aimed to investigate the effect of ponatinib on the procoagulant activity of cultured endothelial cells in vitro. Human coronary artery endothelial cells (HCAECs) were incubated with 50, 150, and 1000 nM of ponatinib. Subsequently, phosphatidylserine (PS) exposure and endothelial microvesicles (EMVs) were measured by flow cytometry. In addition, EC- and EMV-dependent thrombin generation was analyzed. To investigate pro-apoptotic effects of ponatinib, the level of Bax and Bcl-xL proteins were studied using Western blot and F3, THBD, and VCAM1 mRNAs were quantified by qPCR. Therapeutic concentrations of ponatinib significantly increased PS expression on ECs and the amount of EMVs which significantly shortened the time parameters of thrombin generation. In addition, these changes were associated with an increased ratio of Bax and Bcl-xL proteins in the presence of the decreased THBD mRNA level. Overall, ponatinib enhances the procoagulant activity of ECs via inducing apoptosis, which may contribute to thrombotic events. Full article

Emergency vehicles (EMVs) play an important role in saving human lives and mitigating property losses in urban traffic systems. Due to traffic congestion and improper priority control strategies along the rescue route, EMVs may not be able to arrive at rescue spots on time, which also increases traffic risk and has a negative impact on social vehicles (SVs). The greater the negative impact on SVs, such as increased delay times and queue length, the more profound the negative impacts on urban environmental sustainability. Proper rescue route selection and priority control strategies are essential for addressing this problem. Consequently, this paper systematically reviews the studies on EMV routing and priority control. First, a general bibliometric analysis is conducted using VOSviewer. This study also classifies the existing studies into three parts: EMV travel time prediction (EMV-TTP), EMV routing optimization (EMV-RO), and EMV traffic priority control (EMV-TPC). Finally, this study provides future research suggestions on five aspects: 1. uncovering authentic demand characteristics through EMV data mining, 2. incorporating the distinct characteristics of EMV in EMV-RO models, 3. implementing active EMV-TPC strategies, 4. concentrating more on the negative impacts on SVs, and 5. embracing the emerging technologies in the future urban traffic environment. Full article

The aim of this work was to compare an enhanced monofocal (RayOne EMV RAO200E, Rayner) and standard monofocal (RayOne RAO600C Aspheric, Rayner) intraocular lenses (IOLs) for three nominal powers (+10.00 D, +20.00 D and +30.00 D) as a function of the optical aperture diameter (pupil diameter) using a commercial Schlieren phase-shifting deflectometer NIMO TR1504 (Lambda-X, Belgium). From the wavefront maps measured by this instrument, the radial power profiles, the spherical aberration coefficients of the Zernike polynomial expansion (as a function of the optical aperture radius), and the root-mean-square (RMS) of the high-order aberrations (HOAs) were obtained and analyzed by comparing the two models. The results showed that the effective added power that could be obtained with the enhanced model depended directly on the pupil size and the power of the IOL implanted. The higher additions were achieved with the higher nominal IOL powers. The relationship between the pupil diameter, the corneal aberration of the patients and the power profile of these IOLs could have a crucial implication on the far distance and the final effective addition. However, it is important to note that these findings should be clinically validated through the implantation of these models in patients’ lenses. Full article

This study examines the impacts of the US inflation rate on the bond prices of G7 countries across different maturities using inflation-induced equity market volatility (EMV) to better account for bond price determinants. The regression model, a GED-GARCH (1,1) procedure, is adopted to deal with the volatility clustering and fat tail features in bond return estimation. The testing results indicate that the inflation rate has a negative effect on bond returns across different maturities, although an exception occurs for longer maturities in Japan. Evidence shows that US inflation has a significant impact on bond returns for the non-US G7 countries. The negative effects from US inflation are more profound than those from the domestic market (expect in Japan). This study introduces the equity market volatility arising from inflation or the Fed’s interest rate change; this variable produces market volatility that has a positive effect on bond returns, offsetting part of the original negative effect from a rise in inflation. Full article

Electromagnetic vector sensor (EMVS) arrays bring an epochal opportunity for direction finding, as they enable the estimation of two-dimensional direction of arrival (2D-DOA) and polarization characteristics. In this paper, we revisit the 2D-DOA estimation problem in an EMVS rectangle array under multipath propagation. An improved subspace estimator is proposed, which addresses the rank-deficit problem through matrix arrangement, and the 2D-DOA and polarization parameters are estimated via combining the normalized vector cross-product with the least squares method. Our proposed method is suitable for a single snapshot scenario and offers superior accuracy compared to existing methods. To validate its effectiveness, several numerical simulations have been designed and conducted. Full article

Introduction: In stable patients with pulmonary arterial hypertension (PAH), pulmonary rehabilitation (PR) is an effective, safe and cost-effective non-pharmacological treatment. However, the effects of PR on vascular function have been poorly explored. This study aimed to compare the amounts of circulating progenitor cells (PCs) and endothelial microvesicles (EMVs) in patients with PAH before and after 8 weeks of endurance exercise training as markers of vascular competence. Methods: A prospective study of 10 consecutive patients with PAH that successfully finished a PR program (8 weeks) was carried out before and after this intervention. Levels of circulating PCs defined as CD34+CD45low progenitor cells and levels of EMVs (CD31+ CD42b-) were measured by flow cytometry. The ratio of PCs to EMVs was taken as a measure of the balance between endothelial damage and repair capacity. Results: All patients showed training-induced increases in endurance time (mean change 287 s). After PR, the number of PCs (CD34+CD45low/total lymphocytes) was increased (p < 0.05). In contrast, after training, the level of EMVs (CD31+ CD42b-/total EMVs) was reduced. The ratio of PCs to EMVs was significantly higher after training (p < 0.05). Conclusion: Our study shows, for the first time, that endurance exercise training in patients with stable PAH has a positive effect, promoting potential mechanisms of damage/repair in favor of repair. This effect could contribute to a positive hemodynamic and clinical response. Full article

AD is a complex, progressive, age-related neurodegenerative disorder representing the most common cause of senile dementia and neurological dysfunction in our elderly domestic population. The widely observed heterogeneity of AD is a reflection of the complexity of the AD process itself and the altered molecular-genetic mechanisms operating in the diseased human brain and CNS. One of the key players in this complex regulation of gene expression in human pathological neurobiology are microRNAs (miRNAs) that, through their actions, shape the transcriptome of brain cells that normally associate with very high rates of genetic activity, gene transcription and messenger RNA (mRNA) generation. The analysis of miRNA populations and the characterization of their abundance, speciation and complexity can further provide valuable clues to our molecular-genetic understanding of the AD process, especially in the sporadic forms of this common brain disorder. Current in-depth analyses of high-quality AD and age- and gender-matched control brain tissues are providing pathophysiological miRNA-based signatures of AD that can serve as a basis for expanding our mechanistic understanding of this disorder and the future design of miRNA- and related RNA-based therapeutics. This focused review will consolidate the findings from multiple laboratories as to which are the most abundant miRNA species, both free and exosome-bound in the human brain and CNS, which miRNA species appear to be the most prominently affected by the AD process and review recent developments and advancements in our understanding of the complexity of miRNA signaling in the hippocampal CA1 region of AD-affected brains. Full article

The decrease in the quality of recycled aggregate due to an increase in the number of recycling is a primary factor that limits the multi-recycling of concrete. This degradation adversely affects concrete performance; thus, the characteristics of recycled aggregate should be considered during the mix design stage, but little research has taken that into account. This study investigates the effect of the equivalent mortar volume (EMV) mix design on some physical, mechanical and durability properties of concrete made of multiple recycled coarse aggregates at 50% and 100% replacement ratios compared to concrete made by the conventional mix design (CMD). The results showed that the performances of concrete by the CMD decreased with an increasing number of recycling cycles. The properties of EMV-based concrete deteriorated with an increase in the number of recycling cycles at 100% replacement ratio due to poor workability caused by a shortage of fresh mortar. However, at 50% replacement, the EMV-based concrete exhibited similar performance across the three cycles of recycling, as well as improved properties over natural aggregate concrete. This study demonstrated that an appropriate mix design and optimal aggregate replacement ratio can offset the property loss of multiple recycled aggregate concrete. Full article

Background: The remarkable properties of nickel oxide (NiO) and cerium oxide (CeO₂) nanostructures have attracted considerable interest in these nanocomposites as potential electroactive materials for sensor construction. Methods: The mebeverine hydrochloride (MBHCl) content of commercial formulations was determined in this study using a unique factionalized CeO₂/NiO-nanocomposite-coated membrane sensor. Results: Mebeverine-phosphotungstate (MB-PT) was prepared by adding phosphotungstic acid to mebeverine hydrochloride and mixing with a polymeric matrix (polyvinyl chloride, PVC) and plasticizing agent o-nitrophenyl octyl ether. The new suggested sensor showed an excellent linear detection range of the selected analyte at 1.0 × 10⁻⁸–1.0 × 10⁻² mol L⁻¹ with regression equation E_mV = (−29.429 ± 0.2) log [MB] + 347.86. However, the unfunctionalized sensor MB–PT displayed less linearity at 1.0 × 10^−5–1.0 × 10⁻² mol L⁻¹ drug solution with regression equation E_mV = (−26.603 ± 0.5) log [MB] + 256.81. By considering a number of factors, the applicability and validity of the suggested potentiometric system were improved following the rules of analytical methodological requirements. Conclusion: The created potentiometric technique worked well for determining MB in bulk substance and in medical commercial samples. Full article

Transient electromagnetic (TEM) surveys constitute an important element in exploration projects and can be successfully used in the search for oil and gas. Different modifications of the method include shallow (sTEM), 2D, 3D, and 4D (time-lapse) soundings. TEM data allow for solving a large scope of problems for estimating resources and reserves of hydrocarbons, discriminating reservoir rocks, detecting tectonic features, and characterizing drilling conditions. TEM surveys are applicable at all stages, from initial prospecting to production, and are especially efficient when combined with seismic surveys. Each stage has its specific objectives: estimation of net pay thickness, porosity, and fluid type during prospecting, optimization of well placement and prediction of drilling conditions in exploration, and monitoring of flooding during production. Electromagnetic soundings resolve permafrost features well and thus have a high potentiality for exploration in the Arctic petroleum province. At the first reconnaissance stage of regional prospecting in East Siberia, electromagnetic and seismic data were used jointly to map the junction of the Aldan basin (part of the Aldan-Maya foredeep) with the eastern slope of the Aldan uplift and to constrain the limits of Neoproterozoic sediments. The TEM-based images revealed reservoir rocks in the Upper and Middle Neoproterozoic strata. TEM data have implications for the amount of in-place oil and gas resources in prospects, leads, and plays (Russian categories D_1–3) at the prospecting and exploration stages and contingent recoverable reserves (C₂) during exploration (latest stage). The contribution of the TEM survey to oil and gas evaluation is quantified via economic variables, such as the value of information (VOI) and expected monetary value (EMV). Full article