New Insights into the Molecular Mechanisms of Chronic Pain
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 October 2024 | Viewed by 2884
Special Issue Editors
Interests: glial cells; dorsal root ganglia; descending pain modulation
Interests: descending pain modulation; opioids; diffuse noxious inhibitory controls (DNIC)
Special Issue Information
Dear Colleagues,
Chronic pain of various aetiologies affects a high percentage of the population worldwide and is responsible for high costs to society. It is associated with several comorbidities that negatively impact the quality of life of patients and their close relatives. Chronic pain is considered a disease on its own, but the available treatments are not always effective and present many side effects. Despite the progress made in the last few decades towards understanding chronic pain neurobiology, there is still a large gap regarding the role of many cell types, molecules and their receptors, and the molecular identity of all the pathways involved. In particular, the molecular characterization of the circuitries implicated in descending modulation as well as those related with the cognitive and affective dimensions of pain is still underexplored. Also relevant, but poorly investigated, are the differences between sexes in pain circuitries and how they affect chronic pain. In this Special Issue, we welcome all manuscripts bringing new insights into these topics.
Dr. Fani L. Neto
Dr. Isabel Martins
Guest Editors
Manuscript Submission Information
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Keywords
- dorsal root ganglia
- spinal cord
- brain
- opioids
- monoamines
- GABA
- anxiety
- depression
- cognition
- optogenetics
- electrophysiology
- behavior
- glial cells
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