Breast Cancer: From Pathophysiology to Novel Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 150
Special Issue Editor
Interests: triple-negative breast cancer; tumor microenvironment; humoral immunity; chemo/radiation response
Special Issue Information
Dear Colleagues,
Advancements in breast cancer research are increasingly focused on the interplay between genetics and the tumor microenvironment (TME). Understanding the genetic mutations and variations that drive breast cancer helps identify targets for novel therapies. The TME, which includes immune cells, stromal cells, and extracellular matrix, also plays a crucial role in stemness, tumor progression, and response to treatment. New model systems, such as patient-derived organoids, strive to replicate the complexity of breast tumors and their microenvironments, enabling more accurate drug screening and personalized therapy development. These organoids retain the genetic and histological features of the original tumors, providing insights into how genetic factors and TME interactions influence cancer behavior and treatment efficacy. By integrating genetic information and TME dynamics, researchers can develop targeted treatments that improve outcomes for breast cancer patients, including those with aggressive subtypes like triple-negative breast cancer (TNBC).
In this Special Issue, we seek original studies on all aspects of breast cancer research related to mechanisms driving stemness, tumor growth, and metastasis, with an emphasis on interactions between genetics and the tumor microenvironment and new model systems to identify and screen novel therapies.
Dr. Jennifer Sims-Mourtada
Guest Editor
Manuscript Submission Information
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Keywords
- breast cancer
- genetics
- tumor microenvironment
- model systems
- organoids
- immune cells
- tumor stroma
- therapeutic resistance
- novel therapies
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