Recent Advances in Hepatobiliary Cancers: From Diagnosis to Treatment (2nd Edition)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 4478
Special Issue Editor
Interests: liver cancer; biliary cancer; gallbladder cancer; immunotherapy; targeted therapy; precision medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of the Special Issue titled “Recent Advances in Hepatobiliary Cancers: From Diagnosis to Treatment”.
Hepatobiliary malignancies, including primary neoplasms of the liver (hepatocellular carcinoma [HCC] and intrahepatic cholangiocarcinoma) and those of the extrahepatic biliary system (distal cholangiocarcinoma and gallbladder carcinoma), are usually aggressive with poor prognosis and limited treatment options. The main objective for the early stage of these tumors is to cure the disease, yet recurrence is common, and most patients with hepatobiliary cancer present with unresectable or advanced disease. Tyrosine kinase inhibitors (TKIs) remain the backbone of systematic therapy for advanced HCC. However, TKIs are gradually being replaced by the combination of atezolizumab (anti-PD-L1) and bevacizumab (anti-VEGF) as first-line treatment. Due to specific challenges such as the immunosuppressive tumor microenvironment of the liver, the development of immunotherapy in hepatobiliary cancers compared to other cancers has lagged. Fortunately, there are multiple early and advanced-stage ongoing clinical trials investigating the efficacy of combination therapies which might change the landscape of HCC management for different stages in the near future. For advanced biliary tract cancers, genomic characterization has paved the way for developing targeted therapies (FGFR2, IDH1, and BRAF inhibitors) and opened the door to precision medicine. More recently, adding an immunotherapy, durvalumab (anti-PD-L1), to standard chemotherapy for biliary tract cancers has shown improvement in survival. Overall, despite evolving treatment options for hepatobiliary malignancies, there is a substantial unmet clinical need for the early detection of disease, expanding current treatment approaches, such as immunotherapy, and finding novel therapies of these debilitating tumors.
For this Special Issue of Cancers, we welcome the submission of original research and review articles that provide an overview of the most recent advances and future challenges for the diagnosis and treatment of hepatobiliary cancers.
Dr. Ilyas Sahin
Guest Editor
Manuscript Submission Information
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Keywords
- hepatobiliary cancers
- hepatocellular carcinoma
- cholangiocarcinoma
- gallbladder cancer
- immunotherapy
- targeted therapy
- precision medicine
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