New Insights into Thyroid Cancer Surgery

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 955

Special Issue Editors


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Guest Editor
Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy
Interests: endocrine surgery; thyroid surgery; adrenal surgery; parathyroid surgery; hereditary endocrine tumors; minimally invasive surgery

E-Mail Website
Guest Editor
Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy
Interests: endocrine surgery; thyroid surgery; adrenal surgery; parathyroid surgery; hereditary endocrine tumors; minimally invasive surgery

Special Issue Information

Dear Colleagues,

Thyroid cancer is the most common endocrine malignancy, with an increased incidence in last years. Even if active surveillance and minimally invasive interventions have been proposed for low-risk differentiated thyroid cancer (DTC), surgery remains the mainstay of treatment for patients with a suspected or cytologically confirmed DTC; however, controversy over the most appropriate extent of thyroid resection (lobectomy vs. total thyroidectomy) remains. In fact, the risk of recurrent laryngeal nerve palsy is higher in total thyroidectomy compared to lobectomy, as are the risk of hypoparathyroidism and the need for thyroid hormone replacement. Another controversial issue in thyroid cancer surgery is the management of central lymph node dissection; even if central lymph node dissection is required for clinically evident lymph node metastasis, the role of prophylactic lymph node dissection is still debated. Moreover, although total thyroidectomy with bilateral central lymph node dissection is mandatory in patients with medullary thyroid carcinoma, the extent of lymph node dissection in the lateral compartment remains controversial. 

The use of even more precise surgical devices and new technology allows safer surgery, simplifying the preservation of nerves, blood vessels, and parathyroid glands. On this issue, intraoperative neuromonitoring has facilitated the early identification of recurrent laryngeal nerve injuries, and intraoperative parathyroid autofluorescence as well as indocyanine green angiography were carried out to visualize and preserve parathyroid gland function.

In light of such a new scenario, the aim of this Special Issue of Cancers is to analyze the previously described various issues in thyroid cancer surgery to offer new perspectives, promote innovative approaches, and provide a comprehensive overview of the current developments in thyroid cancer surgery. For this purpose, we welcome original research articles or comprehensive review articles that will provide a critical analysis of these issues to further increase our knowledge of thyroid cancer.

Dr. Maurizio Iacobone
Dr. Francesca Torresan
Guest Editors

Manuscript Submission Information

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Keywords

  • total thyroidectomy
  • differentiated thyroid cancer
  • lymph node dissection
  • parathyroid autofluorescence
  • medullary thyroid carcinoma
  • recurrent laryngeal nerve neuromonitoring

Published Papers (1 paper)

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Research

17 pages, 1041 KiB  
Article
Initial versus Staged Thyroidectomy for Differentiated Thyroid Cancer: A Retrospective Multi-Dimensional Cohort Analysis of Effectiveness and Safety
by Eman A. Toraih, Mohammad H. Hussein, Jessan A. Jishu, Madeleine B. Landau, Ahmed Abdelmaksoud, Yaser Y. Bashumeel, Mahmoud A. AbdAlnaeem, Rithvik Vutukuri, Christine Robbie, Chelsea Matzko, Joshua Linhuber, Mohamed Shama, Salem I. Noureldine and Emad Kandil
Cancers 2024, 16(12), 2250; https://doi.org/10.3390/cancers16122250 - 18 Jun 2024
Viewed by 656
Abstract
The optimal surgical approach for differentiated thyroid cancer remains controversial, with debate regarding the comparative risks of upfront total thyroidectomy versus staged completion thyroidectomy following the initial lobectomy. This study aimed to assess the complication rates associated with these two strategies and identify [...] Read more.
The optimal surgical approach for differentiated thyroid cancer remains controversial, with debate regarding the comparative risks of upfront total thyroidectomy versus staged completion thyroidectomy following the initial lobectomy. This study aimed to assess the complication rates associated with these two strategies and identify the optimal timing for completion thyroidectomy using a multi-dimensional analysis of four cohorts: an institutional series (n = 148), the National Surgical Quality Improvement Program (NSQIP) database (n = 39,992), the TriNetX repository (n > 30,000), and a pooled literature review (10 studies, n = 6015). Institutional data revealed higher overall complication rates with total thyroidectomy (18.3%) compared to completion thyroidectomy (6.8%), primarily due to increased temporary hypocalcemia (10% vs. 0%, p = 0.004). The NSQIP analysis demonstrated that total thyroidectomy was associated with a 72% increased risk of transient hypocalcemia (p < 0.001) and a 25% increased risk of permanent hypocalcemia (p < 0.001). TriNetX data confirmed these findings and identified obesity and concurrent neck dissection as risk factors for complications. A meta-analysis showed that total thyroidectomy increased the rates of transient (RR = 1.63) and permanent (RR = 1.23) hypocalcemia (p < 0.001). Institutional and TriNetX data suggested that performing completion thyroidectomy between 1 and 6 months after the initial lobectomy minimized permanent complication rates compared to delays beyond 6 months. In conclusion, for differentiated thyroid cancer, total thyroidectomy is associated with higher risks of transient and permanent hypocalcemia compared to staged completion thyroidectomy. However, performing completion thyroidectomy within 1–6 months of the initial lobectomy may mitigate the risk of permanent complications. These findings can inform personalized surgical decision-making for patients with differentiated thyroid cancer. Full article
(This article belongs to the Special Issue New Insights into Thyroid Cancer Surgery)
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