The Self-Expandable Impella CP (ECP) as a Mechanical Resuscitation Device
Abstract
:1. Introduction
2. Materials and Methods
2.1. Impella ECP pLVAD
2.2. Preparation
2.3. Cardiac Arrest and Resuscitation
2.4. Follow-Up
2.5. Measurements
2.6. Statistical Analysis
3. Results
4. Discussion
5. Limitations
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | Value ± SD |
---|---|
Vascular access complications [n] | 0 |
pLVAD implantation time [s] | 59 ± 28 |
Implantation success [%] | 100 |
Defibrillation attempts [n] | 3.5 ± 2 |
Time to ROSC [min] | 11.33 ± 2.07 |
Norepinephrine [mg] | 1.8 ± 0.4 |
Survival [n] [%] | 6/8; 75% |
BL (n = 8) | PR 10 (n = 6) | PR30 (n = 6) | PR 120 (n = 6) | PR 300 (n = 6) | PR 360 (n = 6) | |
---|---|---|---|---|---|---|
HR [bpm] | 73 ± 15 | 144 ± 33 | 134 ± 43 | 86 ± 10 | 67 ± 11 | 70 ± 17 |
MAP [mmHg] | 86 ± 12 | 94 ± 19 | 57 ± 20 | 77 ± 15 | 80 ± 9 | 79 ± 8 |
MPAP [mmHg] | 21 ± 1 | 23 ± 5 | 21 ± 4 | 21 ± 3 | 23 ± 2 | 22 ± 2 |
CVP [mmHg] | 10 ± 2 | 11 ± 2 | 12 ± 4 | 11 ± 2 | 12 ± 2 | 11 ± 2 |
PCWP [mmHg] | 14 ± 3 | 15 ± 3 | 15 ± 2 | 15 ± 2 | 14 ± 2 | 13 ± 2 |
CO [L/min] | 6.9 ± 1.1 | 10.0 ± 1.6 | 7.8 ± 2.0 | 6.1 ± 0.7 | 5.1 ± 0.4 | 5.1 ± 0.9 |
pLVAD flow [L/min] | 0 ± 0 | 2.9 ± 0.5 | 3.3 ± 0.9 | 3.0 ± 0.8 | 3.0 ± 0.6 | 0 ± 0 |
paO2 [mmHg] | 144 ± 20 | 472 ± 94 | 173 ± 38 | 161 ± 10 | 167 ± 12 | 171 ± 14 |
paCO2 [mmHg] | 38 ± 2 | 42 ± 3 | 40 ± 4 | 37 ± 2 | 37 ± 1 | 38 ± 1 |
SvO2 [%] | 62 ± 8 | 82 ± 4 | 53 ± 16 | 53 ± 9 | 52 ± 6 | 54 ± 9 |
pH | 7.47 ± 0.04 | 7.3 ± 0.05 | 7.34 ± 0.02 | 7.45 ± 0.04 | 7.49 ± 0.00 | 7.49 ± 0.01 |
Hb [g/dL] | 9.3 ± 0.7 | 11.4 ± 0.7 | 10.1 ± 0.9 | 9.5 ± 0.6 | 8.9 ± 0.9 | 8.8 ± 0.9 |
Lactate [mmol/L] | 1.7 ± 2.3 | 8.1 ± 2.4 | 8.9 ± 1.7 | 4.8 ± 1.2 | 0.8 ± 0.1 | 0.8 ± 0.1 |
Glucose [mg/dL] | 111 ± 20 | 185 ± 56 | 151 ± 71 | 129 ± 29 | 111 ± 12 | 104 ± 10 |
PLT/nL [n] | 280 ± 65 | 204 ± 37 | ||||
WBC/nL [n] | 18.9 ± 4.4 | 13.3 ± 5.3 |
BL (n = 7) | PR 30 (n = 5) | PR 300 (n = 5) | PR 360 (n = 5) | |
---|---|---|---|---|
LV-EF [%] | 59 ± 7 | 45 ± 9 | 66 ± 12 | 59 ± 19 |
LV-GLS [%] | −24.2 ± 3.3 | −11.9 ± 5.8 | −23.4 ± 3.8 | −20.1 ± 4.1 |
RV-GLS [%] | −26.2 ± 4.4 | −14.0 ± 5.9 | −23.7 ± 3.2 | −18.6 ± 6.2 |
RVD basal [mm] | 28 ± 5 | 30 ± 7 | 30 ± 6 | 29 ± 4 |
TASV [cm/s] | 10.8 ± 2.2 | 7.0 ± 3.3 | 8.4 ± 1.5 | 9.4 ± 1.5 |
E/A | 1.8 ± 0.8 | 1.8 ± 1.2 | 1.7 ± 0.5 | 1.3 ± 0.2 |
DT MV [ms] | 253 ± 151 | 130 ± 80 | 191 ± 77 | 213 ± 67 |
E/E’ | 7.1 ± 2.3 | 8.8 ± 3.5 | 5.6 ± 2.7 | 7.5 ± 2.8 |
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Billig, S.; Zayat, R.; Yelenski, S.; Nix, C.; Bennek-Schoepping, E.; Hochhausen, N.; Derwall, M. The Self-Expandable Impella CP (ECP) as a Mechanical Resuscitation Device. Bioengineering 2024, 11, 456. https://doi.org/10.3390/bioengineering11050456
Billig S, Zayat R, Yelenski S, Nix C, Bennek-Schoepping E, Hochhausen N, Derwall M. The Self-Expandable Impella CP (ECP) as a Mechanical Resuscitation Device. Bioengineering. 2024; 11(5):456. https://doi.org/10.3390/bioengineering11050456
Chicago/Turabian StyleBillig, Sebastian, Rachad Zayat, Siarhei Yelenski, Christoph Nix, Eveline Bennek-Schoepping, Nadine Hochhausen, and Matthias Derwall. 2024. "The Self-Expandable Impella CP (ECP) as a Mechanical Resuscitation Device" Bioengineering 11, no. 5: 456. https://doi.org/10.3390/bioengineering11050456